Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 3:12 p.m.

The MLB's Thursday slate includes the San Diego Padres facing the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (71-56) vs. San Francisco Giants (61-66)
• Date: Thursday, August 21, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and NBCS-BA

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-190) | SF: (+160)
• Spread: SD: -1.5 (+116) | SF: +1.5 (-140)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 5-11, 4.61 ERA vs Justin Verlander (Giants) - 1-9, 4.32 ERA

The Padres will give the ball to Dylan Cease (5-11, 4.61 ERA), who is eyeing win No. 6 on the season, and the Giants will turn to Justin Verlander (1-9, 4.32 ERA). Cease and his team are 11-14-0 ATS this season when he starts. Cease's team has been victorious in 64.7% of the games he's started as the moneyline favorite with a record of 11-6. The Giants have a 5-16-0 ATS record in Verlander's 21 starts with a set spread. The Giants have been the underdog on the moneyline in nine of Verlander's starts this season, and they went 2-7 in those games.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.8%)

Padres vs Giants Moneyline

• San Diego is a -190 favorite on the moneyline, while San Francisco is a +160 underdog on the road.

Padres vs Giants Spread

• The Padres are favored by 1.5 runs at home versus the Giants. The Padres are +116 to cover the spread, while the Giants are -140.

Padres vs Giants Over/Under

• Padres versus Giants on Aug. 21 has an over/under of 7.5 runs, with the odds on the over -120 and the under set at -102.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have come away with 41 wins in the 66 contests they have been listed as the favorites in this season.
• San Diego has a record of 8-4 when favored by -190 or more this year.
• The Padres and their opponents have gone over the total this season in 53 of their 125 opportunities.
• In 125 games with a line this season, the Padres have a mark of 70-55-0 against the spread.
• The Giants are 22-26 in games they were the underdog on the moneyline (winning 45.8% of those games).
• San Francisco has played as a moneyline underdog of +160 or longer in just two games this season, which it lost both.
• The Giants have had an over/under set by oddsmakers 127 times, and have combined with opponents to go over the total in 57 of those games (57-64-6).
• The Giants have collected a 54-73-0 record against the spread this season (covering 42.5% of the time).

Padres Player Leaders

• Manny Machado leads San Diego with 143 hits and a team-best slugging percentage of .484. He's batting .292 with an on-base percentage of .353.
• He ranks 16th in batting average, 38th in on-base percentage, and 31st in slugging among all qualified hitters in baseball.
• Machado has recorded a base hit in three games in a row. During his last five outings he is hitting .250 with a double, a home run, a walk and two RBIs.
• Fernando Tatis Jr. is batting .266 with 24 doubles, two triples, 17 home runs and 74 walks, while slugging .433 with an on-base percentage of .372.
• He ranks 55th in batting average, 16th in on-base percentage and 80th in slugging among qualifying batters.
• Tatis takes a two-game streak with at least one hit into this contest. During his last five outings he is hitting .316 with three doubles, four walks and three RBIs.
• Luis Arraez has 142 hits this season and has a slash line of .287/.323/.395.
• Xander Bogaerts is batting .262 with a .331 OBP and 43 RBI for San Diego this season.

Giants Player Leaders

• Rafael Devers has put up an on-base percentage of .375 and has 121 hits, both team-best marks for the Giants. He's batting .254 and slugging .463.
• Including all qualifying hitters in MLB, his batting average puts him 92nd, his on-base percentage ranks 11th, and he is 54th in slugging.
• Jung Hoo Lee is hitting .262 with 29 doubles, 10 triples, seven home runs and 39 walks. He's slugging .415 with an on-base percentage of .324.
• Including all qualified players, he is 64th in batting average, 92nd in on-base percentage and 91st in slugging percentage.
• Willy Adames is batting .221 with 18 doubles, two triples, 19 home runs and 58 walks.
• Heliot Ramos leads his team with a .407 slugging percentage.

Padres vs Giants Head to Head

• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2025: 3-2 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/2/2025: 1-0 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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