Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 20

Odds updated as of 9:12 p.m.

In MLB action on Wednesday, the San Diego Padres face the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Padres vs Giants Game Info

• San Diego Padres (70-56) vs. San Francisco Giants (61-65)
• Date: Wednesday, August 20, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: MLB Network, SDPA, and NBCS-BA

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-132) | SF: (+112)
• Spread: SD: -1.5 (+158) | SF: +1.5 (-192)
• Total: 8 -- Over: (-110) | Under: (-110)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: JP Sears (Padres) - 7-10, 5.12 ERA vs Landen Roupp (Giants) - 7-6, 3.54 ERA

The probable starters are JP Sears (7-10) for the Padres and Landen Roupp (7-6) for the Giants. When Sears starts, his team is 12-11-0 against the spread this season. When Sears starts a game and his team is the favorite on the moneyline, they have a record of 3-2. The Giants are 11-10-0 ATS in Roupp's 21 starts with a set spread. The Giants have been the moneyline underdog in 13 of Roupp's starts this season, and they went 7-6 in those matchups.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.4%)

Padres vs Giants Moneyline

• San Francisco is a +112 underdog on the moneyline, while San Diego is a -132 favorite at home.

Padres vs Giants Spread

• The Giants are +1.5 on the spread (-192 to cover), and San Diego is +158 to cover the runline.

Padres vs Giants Over/Under

• The over/under for the Padres versus Giants contest on Aug. 20 has been set at 8, with -110 odds on the over and -110 odds on the under.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have come away with 40 wins in the 65 contests they have been listed as the favorites in this season.
• San Diego has a record of 32-17 when favored by -132 or more this year.
• Contests with the Padres have gone over the total set by sportsbooks in 52 of 124 chances this season.
• The Padres are 69-55-0 against the spread in their 124 games with a line set by sportsbooks this season.
• The Giants have been the moneyline underdog 47 total times this season. They've finished 22-25 in those games.
• San Francisco has a record of 13-15 when playing as a moneyline underdog with odds of +112 or longer (46.4%).
• The Giants have played in 126 games with a set over/under, and have combined with opponents to go over the total 56 times (56-64-6).
• The Giants have gone 54-72-0 ATS this season.

Padres Player Leaders

• Manny Machado has 142 hits to go with a slugging percentage of .479, both of which are best among San Diego hitters this season. He has a .292 batting average and an on-base percentage of .354.
• Among qualifying hitters, he is 15th in batting average, his on-base percentage ranks 36th, and he is 33rd in slugging.
• Machado has recorded at least one hit in two straight games. In his last five games he is hitting .200 with a double, a walk and an RBI.
• Fernando Tatis Jr. leads San Diego in OBP (.370) this season, fueled by 124 hits. He's batting .264 while slugging .431.
• Among qualifying batters, his batting average ranks him 60th, his on-base percentage 15th, and his slugging percentage 79th.
• Luis Arraez leads San Diego in slugging percentage (.398) powered by 37 extra-base hits.
• Arraez has recorded at least one base hit in four straight games. In his last five games he is hitting .300 with four doubles, a walk and two RBIs.
• Xander Bogaerts is batting .262 with a .331 OBP and 43 RBI for San Diego this season.

Giants Player Leaders

• Rafael Devers has a team-best OBP (.376), while leading the Giants in hits (121). He's batting .255 and slugging.
• Including all qualifying hitters, he ranks 89th in batting average, while his on-base percentage ranks 10th and he is 47th in slugging.
• Jung Hoo Lee has 29 doubles, 10 triples, seven home runs and 39 walks while hitting .262. He's slugging .417 with an on-base percentage of .325.
• Including all qualified hitters, he is 66th in batting average, 87th in on-base percentage and 90th in slugging percentage.
• Willy Adames is batting .222 with 18 doubles, two triples, 19 home runs and 57 walks.
• Heliot Ramos leads his team with a .406 slugging percentage.

Padres vs Giants Head to Head

• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2025: 3-2 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/2/2025: 1-0 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/30/2025: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)

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