Brewers vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 20

Odds updated as of 7:12 p.m.

The Wednesday slate in MLB includes a matchup between the Milwaukee Brewers and the Chicago Cubs.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Cubs Game Info

• Milwaukee Brewers (79-47) vs. Chicago Cubs (72-54)
• Date: Wednesday, August 20, 2025
• Time: 8:05 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and FDSWI

Brewers vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | CHC: (-100)
• Spread: MIL: -1.5 (+150) | CHC: +1.5 (-182)
• Total: 6.5 -- Over: (-118) | Under: (-104)

Brewers vs Cubs Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 4-1, 3.89 ERA vs Colin Rea (Cubs) - 9-5, 3.99 ERA

The Brewers will give the ball to Jacob Misiorowski (4-1, 3.89 ERA), who is eyeing win No. 5 on the season, and the Cubs will counter with Colin Rea (9-5, 3.99 ERA). When Misiorowski starts, his team is 7-1-0 against the spread this season. Misiorowski's team is 1-1 this season when he starts and they're favored on the moneyline. When Rea starts, the Cubs have gone 12-8-0 against the spread. The Cubs have been the underdog on the moneyline in six of Rea's starts this season, and they went 4-2 in those games.

Brewers vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (51.1%)

Brewers vs Cubs Moneyline

• Chicago is the underdog, -100 on the moneyline, while Milwaukee is a -118 favorite despite being on the road.

Brewers vs Cubs Spread

• The Brewers are 1.5-run road favorites on the runline against the Cubs. The Brewers are +150 to cover, and the Cubs are -182.

Brewers vs Cubs Over/Under

• The over/under for the Brewers versus Cubs game on Aug. 20 has been set at 6.5, with -118 odds on the over and -104 odds on the under.

Bet on Milwaukee Brewers vs. Chicago Cubs on FanDuel today!

Brewers vs Cubs Betting Trends

• The Brewers have won in 46, or 69.7%, of the 66 contests they have been named as odds-on favorites in this year.
• This year Milwaukee has won 42 of 59 games when listed as at least -118 on the moneyline.
• Contests with the Brewers have gone over the total set by sportsbooks in 60 of 124 chances this season.
• The Brewers are 73-51-0 against the spread in their 124 games that had a posted line this season.
• The Cubs have gone 15-22 in games they were the underdog on the moneyline (winning 40.5% of those games).
• When it has played as a moneyline underdog with odds of -100 or longer, Chicago has gone 12-15 (44.4%).
• The Cubs have played in 122 games with a set over/under, and have combined with their opponents to go over the total 57 times (57-57-8).
• The Cubs have collected a 58-64-0 record against the spread this season.

Brewers Player Leaders

• Christian Yelich has 14 doubles, 26 home runs and 50 walks while hitting .265. He has an on-base percentage of .344 and a slugging percentage of .467.
• Among all qualified hitters, he ranks 55th in batting average, his on-base percentage ranks 50th, and he is 46th in slugging.
• Yelich will look for his third straight game with a hit in this contest. During his last five outings he is batting .105 with a home run, three walks and an RBI.
• William Contreras is batting .260 with 22 doubles, 13 home runs and 70 walks, while slugging .395 with an on-base percentage of .359.
• Among qualifying hitters, his batting average ranks him 73rd, his on-base percentage 27th, and his slugging percentage 116th.
• Contreras has picked up a hit in two straight games. During his last five outings he is batting .238 with a home run, three walks and two RBIs.
• Brice Turang leads Milwaukee in slugging percentage (.415) powered by 36 extra-base hits.
• Turang has recorded a hit in three games in a row. During his last five outings he is batting .333 with a double, a home run, a walk and four RBIs.
• Sal Frelick has 121 hits this season and a team-best OBP of .363.
• Frelick enters this game on a three-game hitting streak. During his last five outings he is hitting .333 with a double, four walks and two RBIs.

Cubs Player Leaders

• Kyle Tucker has put up a team-high .374 on-base percentage. He's batting .261 and slugging .447.
• Including all qualified players in the majors, he ranks 70th in batting average, 12th in on-base percentage and 67th in slugging percentage.
• Pete Crow-Armstrong leads his team with 123 hits. He has a batting average of .259 while slugging .516 with an on-base percentage of .299.
• Including all qualified players, he is 78th in batting average, 135th in on-base percentage and 15th in slugging percentage.
• Seiya Suzuki is hitting .247 with 27 doubles, three triples, 27 home runs and 53 walks.
• Nico Hoerner paces his team with a .374 slugging percentage.

Brewers vs Cubs Head to Head

• 8/19/2025: 4-1 CHC (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/19/2025: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/18/2025: 7-0 MIL (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/30/2025: 10-3 CHC (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/29/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/28/2025: 8-4 MIL (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/19/2025: 8-7 MIL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/17/2025: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/4/2025: 4-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/3/2025: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!