Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 6

Odds updated as of 11:12 a.m.

On Wednesday in MLB, the San Diego Padres are up against the Arizona Diamondbacks.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Diamondbacks Game Info

• San Diego Padres (63-51) vs. Arizona Diamondbacks (54-60)
• Date: Wednesday, August 6, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: MLB Network, ARID, and SDPA

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-148) | ARI: (+126)
• Spread: SD: -1.5 (+106) | ARI: +1.5 (-128)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Nestor Cortes (Padres) - 1-1, 9.00 ERA vs Anthony DeSclafani (Diamondbacks) - 1-2, 4.91 ERA

This contest's pitching matchup is set, as the Padres will send Nestor Cortes (1-1) to the mound, while Anthony DeSclafani (1-2) will take the ball for the Diamondbacks. Cortes has a record of 1-1-0 ATS in two starts with a spread this season. Cortes' team won his only start as a favorite this season. DeSclafani has started two games with set spreads, and the Diamondbacks failed to cover in both opportunities. The Diamondbacks were named the moneyline underdog for one DeSclafani start this season -- they lost.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (51.2%)

Padres vs Diamondbacks Moneyline

• The Padres vs Diamondbacks moneyline has San Diego as a -148 favorite, while Arizona is a +126 underdog at home.

Padres vs Diamondbacks Spread

• The Diamondbacks are hosting the Padres, and are +1.5 on the runline. The Diamondbacks are +106 to cover the spread, and the Padres are -128.

Padres vs Diamondbacks Over/Under

• Padres versus Diamondbacks, on Aug. 6, has an over/under of 9.5, with the over being -105 and the under -115.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have been chosen as favorites in 58 games this year and have walked away with the win 35 times (60.3%) in those games.
• This season San Diego has been victorious 19 times in 29 chances when named as a favorite of at least -148 on the moneyline.
• The Padres and their opponents have gone over the total this season in 47 of their 112 opportunities.
• The Padres are 62-50-0 against the spread in their 112 games with a line set by sportsbooks this season.
• The Diamondbacks have won 19 of the 43 games they were listed as the moneyline underdog this season (44.2%).
• Arizona has gone 7-3 when it has played as a moneyline underdog with odds of +126 or longer (70%).
• The Diamondbacks have played in 110 games with an over/under set, and have combined with opponents to go over the total 55 times (55-49-6).
• The Diamondbacks are 50-60-0 against the spread this season.

Padres Player Leaders

• Manny Machado has 133 hits to go with a slugging percentage of .505, both of which lead San Diego hitters this season. He has a .302 batting average and an on-base percentage of .362.
• Among qualifying hitters in MLB, his batting average ranks eighth, his on-base percentage ranks 26th, and he is 17th in slugging.
• Machado will look for his third straight game with a hit in this contest. During his last five outings he is hitting .300 with two doubles, two walks and an RBI.
• Fernando Tatis Jr. is hitting .261 with 19 doubles, two triples, 17 home runs and 65 walks, while slugging .434 with an on-base percentage of .364.
• He is 71st in batting average, 22nd in on-base percentage and 74th in slugging among qualifying hitters.
• Luis Arraez is batting .294 with a .401 slugging percentage and 42 RBI this year.
• Xander Bogaerts has been key for San Diego with 109 hits, an OBP of .338 plus a slugging percentage of .387.

Diamondbacks Player Leaders

• Geraldo Perdomo has a slugging percentage of .426, a team-best for the Diamondbacks. He's batting .278 with an on-base percentage of .379.
• Including all the qualifying hitters in the big leagues, his batting average puts him 35th, his on-base percentage ranks 11th, and he is 79th in slugging.
• Perdomo enters this game on a three-game hitting streak. In his last five games he is hitting .333 with two doubles and five walks.
• Corbin Carroll is batting .247 with 20 doubles, 14 triples, 22 home runs and 37 walks. He's slugging .540 with an on-base percentage of .321.
• Including all qualified players, he ranks 107th in batting average, 92nd in on-base percentage and 10th in slugging percentage.
• Ketel Marte has totaled 87 hits with a .389 on-base percentage, leading the Diamondbacks in both categories.
• Lourdes Gurriel Jr. has 21 doubles, two triples, 14 home runs and 26 walks while hitting .249.

Padres vs Diamondbacks Head to Head

• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/13/2025: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/29/2024: 11-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)

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