Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 5

Odds updated as of 9:11 p.m.

In MLB action on Tuesday, the San Diego Padres face the Arizona Diamondbacks.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Diamondbacks Game Info

• San Diego Padres (62-51) vs. Arizona Diamondbacks (54-59)
• Date: Tuesday, August 5, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: MLB Network, ARID, and SDPA

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-134) | ARI: (+114)
• Spread: SD: -1.5 (+118) | ARI: +1.5 (-142)
• Total: 9 -- Over: (-102) | Under: (-120)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 1-3, 6.46 ERA vs Ryne Nelson (Diamondbacks) - 6-3, 3.20 ERA

The Padres will give the nod to Yu Darvish (1-3, 6.46 ERA), who is eyeing win No. 2 on the season, and the Diamondbacks will turn to Ryne Nelson (6-3, 3.20 ERA). Darvish and his team have a record of 2-2-0 against the spread when he starts. Darvish's team is 1-1 this season when he starts and they're favored on the moneyline. The Diamondbacks are 9-4-0 ATS in Nelson's 13 starts with a set spread. The Diamondbacks are 3-2 in Nelson's five starts this season that they were the moneyline underdog.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (52%)

Padres vs Diamondbacks Moneyline

• Arizona is the underdog, +114 on the moneyline, while San Diego is a -134 favorite despite being on the road.

Padres vs Diamondbacks Spread

• The Padres are at the Diamondbacks and are favored by 1.5 runs (+118 to cover) on the runline. Arizona is -142 to cover.

Padres vs Diamondbacks Over/Under

• Padres versus Diamondbacks on Aug. 5 has an over/under of 9 runs, with the odds on the over -102 and the under set at -120.

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Padres vs Diamondbacks Betting Trends

• The Padres have been victorious in 34, or 59.6%, of the 57 contests they have been chosen as favorites in this season.
• This year San Diego has won 26 of 40 games when listed as at least -134 on the moneyline.
• The Padres and their opponents have gone over the total this season in 46 of their 111 opportunities.
• In 111 games with a line this season, the Padres have a mark of 61-50-0 against the spread.
• The Diamondbacks have won 19 of the 42 games they were the underdog on the moneyline this season (45.2%).
• Arizona has a 10-7 record (winning 58.8% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Diamondbacks have had an over/under set by bookmakers 109 times, and have combined with opponents to go over the total in 54 of those games (54-49-6).
• The Diamondbacks have covered 45.9% of their games this season, going 50-59-0 ATS.

Padres Player Leaders

• Manny Machado leads San Diego with 130 hits and a team-best slugging percentage of .501. He's batting .299 with an on-base percentage of .358.
• Among all qualified hitters in baseball, he ranks eighth in batting average, 32nd in on-base percentage, and 20th in slugging.
• Fernando Tatis Jr. is hitting .264 with 19 doubles, two triples, 17 home runs and 64 walks. He's slugging .440 with an on-base percentage of .367.
• Among qualifiers, he is 69th in batting average, 21st in on-base percentage and 70th in slugging percentage.
• Tatis heads into this game looking to extend his two-game hit streak. In his last five games he is batting .167 with a double and five walks.
• Luis Arraez has collected 128 base hits, an OBP of .332 and a slugging percentage of .404 this season.
• Xander Bogaerts has seven home runs, 38 RBI and a batting average of .267 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has racked up a slugging percentage of .424, a team-best for the Diamondbacks. He's batting .278 with an on-base percentage of .377.
• Including all qualifying hitters, he is 35th in batting average, while his on-base percentage is 12th and he is 80th in slugging.
• Corbin Carroll has 20 doubles, 14 triples, 22 home runs and 37 walks while hitting .250. He's slugging .547 with an on-base percentage of .325.
• His batting average is 101st among all qualified players, his on-base percentage ranks 81st, and he is ninth in slugging.
• Ketel Marte has racked up 87 hits with a .391 on-base percentage, leading the Diamondbacks in both statistics.
• Lourdes Gurriel Jr. is batting .247 with 21 doubles, two triples, 12 home runs and 26 walks.

Padres vs Diamondbacks Head to Head

• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/13/2025: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/29/2024: 11-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/28/2024: 5-0 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)

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