Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 8

Odds updated as of 9:11 p.m.

The San Diego Padres versus the St. Louis Cardinals is on the MLB schedule for Friday.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cardinals Game Info

• San Diego Padres (22-15) vs. St. Louis Cardinals (22-15)
• Date: Friday, May 8, 2026
• Time: 9:45 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Apple TV+

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | STL: (+124)
• Spread: SD: -1.5 (+136) | STL: +1.5 (-164)
• Total: 8 -- Over: (-105) | Under: (-115)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Griffin Canning (Padres) - 0-0, 1.80 ERA vs Michael McGreevy (Cardinals) - 2-2, 2.52 ERA

The Padres will look to Griffin Canning versus the Cardinals and Michael McGreevy (2-2). Canning and his team failed to cover the spread in his only opportunity this season as a starter. Canning's team won his only start as a favorite this season. When McGreevy starts, the Cardinals are 5-2-0 against the spread. The Cardinals are 3-3 in McGreevy's six starts this season that they were the moneyline underdog.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56%)

Padres vs Cardinals Moneyline

• The Padres vs Cardinals moneyline has San Diego as a -146 favorite, while St. Louis is a +124 underdog on the road.

Padres vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Padres. The Cardinals are -164 to cover the spread, and the Padres are +136.

Padres vs Cardinals Over/Under

• The over/under for the Padres versus Cardinals game on May 8 has been set at 8, with -105 odds on the over and -115 odds on the under.

Bet on San Diego Padres vs. St. Louis Cardinals on FanDuel today!

Padres vs Cardinals Betting Trends

• The Padres have been favorites in 21 games this season and have come away with the win 12 times (57.1%) in those contests.
• San Diego has a record of 9-4 when favored by -146 or more this year.
• The Padres and their opponents have hit the over in 16 of their 37 games with a total set by oddsmakers this season.
• The Padres have an against the spread mark of 21-16-0 in 37 games with a line this season.
• The Cardinals have gone 20-13 in games they were the underdog on the moneyline (winning 60.6% of those games).
• In games it has played as a moneyline underdog with odds of +124 or longer, St. Louis has a record of 6-4 (60%).
• The Cardinals have had an over/under set by bookmakers 37 times, and have combined with opponents to go over the total in 18 of those games (18-16-3).
• The Cardinals have a 23-14-0 record against the spread this season (covering 62.2% of the time).

Padres Player Leaders

• Xander Bogaerts has 36 hits and an OBP of .356 to go with a slugging percentage of .454. All three of those stats rank first among San Diego hitters this season. He has a .277 batting average, as well.
• He ranks 45th in batting average, 57th in on-base percentage, and 51st in slugging among all qualified hitters in the majors.
• Bogaerts has picked up at least one hit in three games in a row. In his last five games he is batting .400 with two home runs, a walk and six RBIs.
• Jackson Merrill has eight doubles, four home runs and 12 walks. He's batting .230 and slugging .374 with an on-base percentage of .296.
• He is 123rd in batting average, 141st in on-base percentage and 118th in slugging among qualified batters.
• Manny Machado has 25 hits this season and has a slash line of .202/.313/.355.
• Ramon Laureano is batting .230 with a .308 OBP and 19 RBI for San Diego this season.

Cardinals Player Leaders

• Jordan Walker has 42 hits with a .588 slugging percentage, both team-best numbers for the Cardinals. He's batting .309 and with an on-base percentage of .383.
• Including all the qualifying players in the big leagues, his batting average ranks 18th, his on-base percentage is 25th, and he is eighth in slugging.
• Alec Burleson is hitting .270 with nine doubles, six home runs and 18 walks. He's slugging .461 with an on-base percentage of .350.
• He is currently 50th in batting average, 66th in on-base percentage and 46th in slugging percentage among all qualified batters.
• JJ Wetherholt is batting .236 with five doubles, seven home runs and 20 walks.
• Ivan Herrera paces his team with a .402 on-base percentage.

Padres vs Cardinals Head to Head

• 5/7/2026: 2-1 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/3/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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