Padres vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 9:11 p.m.

Friday's slate in the MLB includes a matchup between the San Diego Padres and the Athletics.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Padres vs Athletics Game Info

• San Diego Padres (29-20) vs. Athletics (26-24)
• Date: Friday, May 22, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-CA

Padres vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-124) | OAK: (+106)
• Spread: SD: +1.5 (-200) | OAK: -1.5 (+164)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Athletics Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 3-2, 5.01 ERA vs Jeffrey Springs (Athletics) - 3-4, 3.93 ERA

The probable pitchers are Walker Buehler (3-2) for the Padres and Jeffrey Springs (3-4) for the Athletics. Buehler's team is 6-3-0 against the spread in his starts this season. Buehler's team has won 50% of his starts when they are favored on the moneyline (2-2). The Athletics have gone 6-4-0 against the spread when Springs starts. The Athletics have a 2-3 record in Springs' five starts this season when they were the underdog on the moneyline.

Padres vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.9%)

Padres vs Athletics Moneyline

• The Padres vs Athletics moneyline has the Padres as a -124 favorite, while the Athletics are a +106 underdog on the road.

Padres vs Athletics Spread

• The Padres are hosting the Athletics and are 1.5 on the runline and -200 to cover, while Sacramento is +164 to cover the spread.

Padres vs Athletics Over/Under

• Padres versus Athletics on May 22 has an over/under of 7.5 runs, with the odds on the over -118 and the under set at -104.

Bet on San Diego Padres vs. Athletics on FanDuel today!

Padres vs Athletics Betting Trends

• The Padres have come away with 14 wins in the 24 contests they have been listed as the favorites in this season.
• This year, the Padres have won 11 of 19 games when listed as at least -124 or better on the moneyline.
• The Padres and their opponents have hit the over in 21 of their 49 games with a total this season.
• The Padres have posted a record of 28-21-0 against the spread this season.
• The Athletics have won 18 of the 32 games they were the moneyline underdog this season (56.2%).
• When they have played as a moneyline underdog with odds of +106 or longer, the Athletics have a record of 15-11 (57.7%).
• The Athletics have combined with their opponents to hit the over on the total 23 times this season for a 23-26-1 record against the over/under.
• The Athletics have a 26-24-0 record against the spread this season (covering 52% of the time).

Padres Player Leaders

• Xander Bogaerts leads San Diego in OBP (.318), slugging percentage (.385) and total hits (43) this season. He has a .247 batting average.
• Among the qualified hitters in baseball, his batting average ranks 91st, his on-base percentage ranks 102nd, and he is 99th in slugging.
• Gavin Sheets has 10 doubles, nine home runs and 16 walks. He's batting .254 and slugging .530 with an on-base percentage of .338.
• Manny Machado has 30 hits this season and has a slash line of .178/.272/.331.
• Miguel Andujar is batting .290 with a .315 OBP and 17 RBI for San Diego this season.

Athletics Player Leaders

• Shea Langeliers has a slugging percentage of .576 and has 59 hits, both team-best numbers for the Athletics. He's batting .321 and with an on-base percentage of .394.
• Including all qualified players, he is sixth in batting average, while his on-base percentage ranks 10th and he is fifth in slugging.
• Nick Kurtz's .438 OBP paces his team. He has a batting average of .278 while slugging .483.
• Including all qualified hitters, his batting average places him 40th, his on-base percentage ranks first, and he is 35th in slugging.
• Tyler Soderstrom is hitting .196 with 14 doubles, a triple, five home runs and 20 walks.
• Carlos Cortes has eight doubles, a triple, four home runs and 14 walks while batting .345.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!