Orioles vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 7:12 p.m.

The MLB's Friday slate includes the Baltimore Orioles taking on the Detroit Tigers.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Tigers Game Info

• Baltimore Orioles (21-29) vs. Detroit Tigers (20-31)
• Date: Friday, May 22, 2026
• Time: 7:15 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: Apple TV+

Orioles vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-132) | DET: (+112)
• Spread: BAL: -1.5 (+162) | DET: +1.5 (-196)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Orioles vs Tigers Probable Starting Pitchers

Probable Pitchers: Keegan Akin (Orioles) - 0-0, 13.50 ERA vs Jack Flaherty (Tigers) - 0-5, 5.77 ERA

The probable pitchers are Keegan Akin for the Orioles and Jack Flaherty (0-5) for the Tigers. Akin helped his team cover the spread in his only opportunity this season as a starter. Akin has yet to start a game this season when his team was the moneyline favorite. When Flaherty starts, the Tigers are 2-8-0 against the spread. The Tigers were named the moneyline underdog for three Flaherty starts this season -- they lost all of the games.

Orioles vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (56.3%)

Orioles vs Tigers Moneyline

• Detroit is a +112 underdog on the moneyline, while Baltimore is a -132 favorite at home.

Orioles vs Tigers Spread

• The Orioles are hosting the Tigers and are favored by 1.5 runs (+162 to cover) on the runline. Detroit is -196 to cover.

Orioles vs Tigers Over/Under

• The Orioles-Tigers contest on May 22 has been given an over/under of 8.5 runs. The over is set at +100 and the under at -122.

Bet on Baltimore Orioles vs. Detroit Tigers on FanDuel today!

Orioles vs Tigers Betting Trends

• The Orioles have been favorites in 25 games this season and have come away with the win 13 times (52%) in those contests.
• This season Baltimore has been victorious six times in 13 chances when named as a favorite of at least -132 on the moneyline.
• The Orioles and their opponents have hit the over in 28 of their 50 games with a total set by oddsmakers this season.
• The Orioles are 21-29-0 against the spread in their 50 games that had a posted line this season.
• The Tigers have put together a 7-14 record in games they were the underdog on the moneyline (winning 33.3% of those games).
• Detroit is 1-6 (winning just 14.3% of its games) when it has played as a moneyline underdog of +112 or longer.
• The Tigers have had an over/under set by oddsmakers 50 times, and have combined with opponents to go over the total in 21 of those games (21-28-1).
• The Tigers have covered 50% of their games this season, going 25-25-0 against the spread.

Orioles Player Leaders

• Taylor Ward has 45 hits this season and a team-best OBP of .415. He has a .257 batting average and a slugging percentage of .377.
• Among qualified batters in the majors, his batting average ranks 73rd, his on-base percentage ranks fourth, and he is 109th in slugging.
• Pete Alonso leads Baltimore with 43 hits. He is batting .228 this season and has 21 extra-base hits. He's also slugging .434 with an on-base percentage of .310.
• Among qualifying batters, his batting average places him 122nd, his on-base percentage 117th, and his slugging percentage 63rd.
• Adley Rutschman is batting .266 with a .508 slugging percentage and 26 RBI this year.
• Gunnar Henderson has an OPS of .687, fueled by an OBP of .271 and a team-best slugging percentage of .416 this season.
• Henderson enters this game on a two-game hitting streak. In his last five games he is batting .381 with a double, a home run, a walk and two RBIs.

Tigers Player Leaders

• Kevin McGonigle is hitting .286 with 12 doubles, two triples, two home runs and 31 walks. He's slugging .407 with an on-base percentage of .395.
• He is 34th in batting average, eighth in on-base percentage and 84th in slugging percentage among all qualifying hitters in MLB.
• Riley Greene's 59 hits, .422 on-base percentage and .475 slugging percentage all pace his team. He has a batting average of .326.
• He is currently second in batting average, second in on-base percentage and 40th in slugging percentage among all qualifying batters.
• Dillon Dingler has 10 doubles, nine home runs and 14 walks while batting .241.
• Matt Vierling is hitting .200 with nine doubles, four home runs and 14 walks.

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