Orioles vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 6:11 p.m.

The MLB slate on Tuesday includes the St. Louis Cardinals facing the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cardinals vs Orioles Game Info

• St. Louis Cardinals (30-24) vs. Baltimore Orioles (19-34)
• Date: Tuesday, May 27, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and FDSMW

Cardinals vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-120) | BAL: (+102)
• Spread: STL: -1.5 (+134) | BAL: +1.5 (-162)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Cardinals vs Orioles Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 4-3, 4.18 ERA vs Tomoyuki Sugano (Orioles) - 4-3, 3.07 ERA

This contest's pitching matchup is set, as the Cardinals will send Andre Pallante (4-3) to the mound, while Tomoyuki Sugano (4-3) will get the nod for the Orioles. Pallante and his team are 6-4-0 ATS this season when he starts. Pallante's team is 1-1 this season when he starts and they're favored on the moneyline. The Orioles are 5-5-0 ATS in Sugano's 10 starts with a set spread. The Orioles are 3-1 in Sugano's four starts this season that they were the moneyline underdog.

Cardinals vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53.7%)

Cardinals vs Orioles Moneyline

• St. Louis is the favorite, -120 on the moneyline, while Baltimore is a +102 underdog despite being at home.

Cardinals vs Orioles Spread

• The Cardinals are 1.5-run road favorites on the runline against the Orioles. The Cardinals are +134 to cover, and the Orioles are -162.

Cardinals vs Orioles Over/Under

• A combined run total of 8.5 has been set for Cardinals-Orioles on May 27, with the over at -110 and the under at -110.

Bet on St. Louis Cardinals vs. Baltimore Orioles on FanDuel today!

Cardinals vs Orioles Betting Trends

• The Cardinals have been victorious in 10, or 52.6%, of the 19 contests they have been chosen as favorites in this season.
• St. Louis has a record of 8-2 when favored by -120 or more this year.
• The Cardinals and their opponents have gone over the total this season in 27 of their 54 opportunities.
• The Cardinals are 30-24-0 against the spread in their 54 games that had a posted line this season.
• The Orioles have put together a 10-14 record in games they were listed as the moneyline underdog (winning 41.7% of those games).
• Baltimore is 5-10 (winning just 33.3% of its games) when playing as a moneyline underdog of +102 or longer.
• The Orioles have had an over/under set by bookmakers 53 times, and have combined with opponents to go over the total in 26 of those games (26-25-2).
• The Orioles have covered just 34% of their games this season, going 18-35-0 against the spread.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with 66 hits and an OBP of .390, plus a team-best slugging percentage of .463. He's batting .328.
• Among all qualifying hitters in MLB, he is seventh in batting average, 14th in on-base percentage, and 48th in slugging.
• Donovan has recorded a base hit in three games in a row. During his last five outings he is batting .313 with two doubles and three walks.
• Lars Nootbaar is hitting .239 with 10 doubles, seven home runs and 32 walks, while slugging .390 with an on-base percentage of .344.
• He ranks 109th in batting average, 57th in on-base percentage and 105th in slugging in the major leagues.
• Nolan Arenado has collected 44 base hits, an OBP of .306 and a slugging percentage of .378 this season.
• Victor Scott II has two home runs, 19 RBI and a batting average of .273 this season.

Orioles Player Leaders

• Ryan O'Hearn has racked up 52 hits with a .426 on-base percentage and a .542 slugging percentage, all club-bests for the Orioles. He's batting .340.
• Including all qualifying hitters in the big leagues, he is fifth in batting average, fourth in on-base percentage and 10th in slugging percentage.
• O'Hearn takes a six-game hitting streak into this matchup. During his last 10 games he is hitting .447 with three doubles, a home run, five walks and four RBIs.
• Cedric Mullins is hitting .226 with nine doubles, 10 home runs and 23 walks. He's slugging .446 with an on-base percentage of .320.
• Including all qualified hitters, his batting average puts him 131st, his on-base percentage ranks 94th, and he is 61st in slugging.
• Gunnar Henderson has 10 doubles, two triples, seven home runs and 17 walks while hitting .266.
• Adley Rutschman is hitting .211 with seven doubles, a triple, five home runs and 24 walks.

Cardinals vs Orioles Head to Head

• 5/26/2025: 5-2 BAL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/20/2024: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/13/2023: 1-0 STL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/12/2023: 5-2 STL (Favorite: Orioles, Spread: -1.5, Total: 11, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/11/2023: 11-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 10, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/11/2022: 10-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/10/2022: 5-3 BAL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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