Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 2:13 a.m.

The Baltimore Orioles versus the Houston Astros is on the MLB schedule for Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Orioles vs Astros Game Info

• Baltimore Orioles (59-68) vs. Houston Astros (70-58)
• Date: Friday, August 22, 2025
• Time: 7:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MLB Network, MASN, and SCHN

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-110) | HOU: (-106)
• Spread: BAL: +1.5 (-188) | HOU: -1.5 (+155)
• Total: 9.5 -- Over: (+106) | Under: (-130)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Cade Povich (Orioles) - 2-6, 4.98 ERA vs Lance McCullers (Astros) - 2-4, 6.90 ERA

The Orioles will give the nod to Cade Povich (2-6) against the Astros and Lance McCullers (2-4). When Povich starts, his team is 3-11-0 against the spread this season. Povich's team has a record of 2-6 this season when he starts and they are the favorite on the moneyline. When McCullers starts, the Astros are 6-5-0 against the spread. The Astros are 4-1 in McCullers' five starts this season that they were the underdog on the moneyline.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (51.9%)

Orioles vs Astros Moneyline

• The Orioles vs Astros moneyline has Baltimore as a -110 favorite, while Houston is a -106 underdog on the road.

Orioles vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Orioles. The Astros are +155 to cover, while the Orioles are -188 to cover as a 1.5-run underdog on the runline.

Orioles vs Astros Over/Under

• The over/under for the Orioles versus Astros game on Aug. 22 has been set at 9.5, with +106 odds on the over and -130 odds on the under.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have been favorites in 54 games this season and have come away with the win 24 times (44.4%) in those contests.
• This year Baltimore has won 24 of 54 games when listed as at least -110 on the moneyline.
• The Orioles and their opponents have hit the over in 54 of their 124 games with a total set by oddsmakers this season.
• The Orioles have posted a record of 58-66-0 against the spread this season.
• The Astros have compiled a 25-17 record in games they were the underdog on the moneyline (winning 59.5% of those games).
• In games it has played as a moneyline underdog with odds of -106 or longer, Houston has a 24-15 record (winning 61.5% of its games).
• In the 127 games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 58 times (58-65-4).
• The Astros have covered 49.6% of their games this season, going 63-64-0 ATS.

Orioles Player Leaders

• Gunnar Henderson leads Baltimore with 126 hits and an OBP of .351, plus a team-best slugging percentage of .467. He's batting .280.
• He ranks 28th in batting average, 41st in on-base percentage, and 48th in slugging among all qualifying hitters in the majors.
• Henderson will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .211 with a triple, a home run, four walks and four RBIs.
• Jackson Holliday is batting .247 with 17 doubles, two triples, 15 home runs and 34 walks, while slugging .387 with an on-base percentage of .305.
• He ranks 102nd in batting average, 121st in on-base percentage and 127th in slugging among qualified batters.
• Holliday heads into this game looking to extend his two-game hit streak. In his last five games he is hitting .238 with a double, a home run, five walks and three RBIs.
• Jordan Westburg has collected 78 base hits, an OBP of .326 and a slugging percentage of .473 this season.
• Ryan Mountcastle has been key for Baltimore with 59 hits, an OBP of .291 plus a slugging percentage of .370.
• Mountcastle enters this game on a seven-game hitting streak. In his last 10 outings he is batting .300 with a double, a home run, two walks and four RBIs.

Astros Player Leaders

• Jose Altuve has put up a team-high .455 slugging percentage. He's batting .274 with an on-base percentage of .338.
• Including all qualified hitters in the big leagues, his batting average puts him 40th, his on-base percentage is 57th, and he is 60th in slugging.
• Jeremy Pena has 117 hits with a .366 OBP to lead his team in both. He has a batting average of .306 while slugging .474.
• He is currently third in batting average, 22nd in on-base percentage and 39th in slugging percentage among all qualifying hitters.
• Yainer Diaz is hitting .254 with 16 doubles, a triple, 18 home runs and 17 walks.
• Christian Walker has 21 doubles, a triple, 17 home runs and 37 walks while batting .233.

Orioles vs Astros Head to Head

• 8/21/2025: 7-2 HOU (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/17/2025: 12-0 BAL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/16/2025: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/15/2025: 7-0 BAL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/25/2024: 6-3 HOU (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/24/2024: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/23/2024: 7-5 BAL (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2024: 6-0 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/23/2024: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/22/2024: 5-1 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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