Notre Dame vs Arkansas Prediction, Odds, Picks, Best Bets for Week 5 2025

The Notre Dame Fighting Irish versus the Arkansas Razorbacks is on the college football schedule for Saturday.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Notre Dame vs Arkansas Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-176) | Arkansas: (+146)
• Spread: Notre Dame: -4.5 (-104) | Arkansas: +4.5 (-118)
• Total: 63.5 -- Over: (-110) | Under: (-110)

Notre Dame vs Arkansas Betting Trends

• Notre Dame has one win against the spread this season.
• Notre Dame has won once ATS (1-1) as a 4.5-point or higher favorite this year.
• All three of Notre Dame's games have gone over the point total this season.
• Arkansas has but one win versus the spread this season.
• Arkansas doesn't have a win ATS (0-1) as a 4.5-point underdog or greater this season.
• Of four Arkansas games so far this year, three have hit the over.

Notre Dame vs Arkansas Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (54.7%)

Notre Dame vs Arkansas Point Spread

Notre Dame is favored by 4.5 points over Arkansas. Notre Dame is -104 to cover the spread, with Arkansas being -118.

Notre Dame vs Arkansas Over/Under

A total of 63.5 points has been set for the Notre Dame-Arkansas matchup on Sept. 27, with the over available at -110 and the under at -110.

Notre Dame vs Arkansas Moneyline

Looking at the moneyline for Notre Dame-Arkansas, Notre Dame is the favorite at -176, and Arkansas is +146.

Notre Dame vs. Arkansas Points Insights

Notre Dame vs. Arkansas Game Info

• Game day: Saturday, September 27, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Fayetteville, Arkansas
• Stadium: Donald W. Reynolds Razorback Stadium

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Check out even more in-depth Notre Dame vs. Arkansas analysis on FanDuel Research.