Notre Dame vs Arkansas Prediction, Odds, Picks, Best Bets for Week 5 2025

In college football action on Saturday, the Notre Dame Fighting Irish face the Arkansas Razorbacks.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Notre Dame vs Arkansas Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-194) | Arkansas: (+160)
• Spread: Notre Dame: -4.5 (-108) | Arkansas: +4.5 (-112)
• Total: 63.5 -- Over: (-110) | Under: (-110)

Notre Dame vs Arkansas Betting Trends

• Notre Dame has posted one win against the spread this season.
• As a 4.5-point or greater favorite, Notre Dame has one win ATS (1-1) this season.
• Every Notre Dame game has hit the over this year.
• Arkansas has one win against the spread this season.
• Arkansas has no wins ATS (0-1) as a 4.5-point underdog or greater this season.
• Arkansas has played four games this season, and three of them have gone over the total.

Notre Dame vs Arkansas Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (54.7%)

Notre Dame vs Arkansas Point Spread

Notre Dame is favored by 4.5 points over Arkansas. Notre Dame is -108 to cover the spread, with Arkansas being -112.

Notre Dame vs Arkansas Over/Under

An over/under of 63.5 has been set for Notre Dame-Arkansas on Sept. 27, with the over being -110 and the under -110.

Notre Dame vs Arkansas Moneyline

The Notre Dame vs Arkansas moneyline has Notre Dame as a -194 favorite, while Arkansas is a +160 underdog.

Notre Dame vs. Arkansas Points Insights

Notre Dame vs. Arkansas Game Info

• Game day: Saturday, September 27, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Fayetteville, Arkansas
• Stadium: Donald W. Reynolds Razorback Stadium

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Check out even more in-depth Notre Dame vs. Arkansas analysis on FanDuel Research.