Missouri vs UMass Prediction, Odds, Picks, Best Bets for Week 5 2025

Saturday's slate in college football includes a matchup between the Missouri Tigers and the UMass Minutemen.

We've got you covered, in terms of the vital info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Missouri vs UMass Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Missouri: (N/A) | UMass: (N/A)
• Spread: Missouri: -44.5 (-115) | UMass: +44.5 (-105)
• Total: 56.5 -- Over: (-115) | Under: (-105)

Missouri vs UMass Betting Trends

• Missouri's record against the spread is 3-1-0.
• Missouri and its opponent have not failed to hit the over in any game this season.
• UMass has not won a game against the spread this year.
• All three UMass games have hit the over this year.

Missouri vs UMass Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (96.2%)

Missouri vs UMass Point Spread

Missouri is favored by 44.5 points over UMass. Missouri is -115 to cover the spread, with UMass being -105.

Missouri vs UMass Over/Under

An over/under of 56.5 has been set for Missouri-UMass on Sept. 27, with the over being -115 and the under -105.

Missouri vs. UMass Points Insights

Missouri vs. UMass Game Info

• Game day: Saturday, September 27, 2025
• Game time: 7:30 p.m. ET
• TV channel: ESPNU
• Location: Columbia, Missouri
• Stadium: Memorial Stadium/Faurot Field

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Missouri vs. UMass analysis on FanDuel Research.