Mets vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 7:11 p.m.

The Tuesday slate in MLB includes a matchup between the New York Mets and the San Diego Padres.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Mets vs Padres Game Info

• New York Mets (77-73) vs. San Diego Padres (82-68)
• Date: Tuesday, September 16, 2025
• Time: 7:10 p.m. ET
• Venue: Citi Field -- Queens, New York
• Coverage: TBS, SNY, and SDPA

Mets vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYM: (-122) | SD: (+104)
• Spread: NYM: +1.5 (-194) | SD: -1.5 (+160)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Mets vs Padres Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Mets) - 11-8, 3.75 ERA vs Michael King (Padres) - 4-2, 2.87 ERA

The Mets will give the nod to Clay Holmes (11-8, 3.75 ERA), who is eyeing win No. 12 on the season, and the Padres will turn to Michael King (4-2, 2.87 ERA). Holmes' team is 11-15-0 against the spread this season in his starts. Holmes' team has a record of 12-8 this season when he starts and they are the favorite on the moneyline. The Padres have a 4-8-0 ATS record in King's 12 starts with a set spread. The Padres were the underdog on the moneyline for two King starts this season -- they split the games.

Mets vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mets win (51.2%)

Mets vs Padres Moneyline

• The Mets vs Padres moneyline has New York as a -122 favorite, while San Diego is a +104 underdog on the road.

Mets vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Mets. The Padres are +160 to cover, while the Mets are -194 to cover as a 1.5-run underdog on the runline.

Mets vs Padres Over/Under

• The over/under for the Mets versus Padres game on Sept. 16 has been set at 7.5, with -122 odds on the over and -100 odds on the under.

Bet on New York Mets vs. San Diego Padres on FanDuel today!

Mets vs Padres Betting Trends

• The Mets have been victorious in 58, or 57.4%, of the 101 contests they have been chosen as favorites in this season.
• This season New York has come away with a win 48 times in 87 chances when named as a favorite of at least -122 on the moneyline.
• The Mets and their opponents have gone over in 66 of their 143 games with a total set by sportsbooks this season.
• The Mets have an against the spread mark of 66-77-0 in 143 games with a line this season.
• The Padres are 30-32 in games they were the underdog on the moneyline (winning 48.4% of those games).
• San Diego is 24-27 (winning 47.1% of its games) when playing as a moneyline underdog of +104 or longer.
• The Padres have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 64 of those games (64-81-3).
• The Padres have gone 80-68-0 ATS this season.

Mets Player Leaders

• Juan Soto leads New York in OBP (.396) and total hits (139) this season. He's batting .262 batting average while slugging .525.
• Among all qualified hitters in MLB, he ranks 61st in batting average, second in on-base percentage, and 11th in slugging.
• Francisco Lindor has an OPS of .785, fueled by an OBP of .337 and a team-best slugging percentage of .448 this season. He's batting .263.
• Among all qualified, he is 54th in batting average, 55th in on-base percentage and 61st in slugging percentage.
• Lindor has picked up at least one hit in four straight games. During his last five outings he is hitting .211 with a double and two walks.
• Pete Alonso has 154 hits this season and has a slash line of .266/.342/.510.
• Alonso has recorded at least one base hit in two games in a row. During his last five outings he is hitting .200 with a home run, a walk and four RBIs.
• Brandon Nimmo has been key for New York with 140 hits, an OBP of .326 plus a slugging percentage of .439.
• Nimmo has hit safely in two straight games. During his last five outings he is batting .200 with a home run and two RBIs.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 22 home runs and 86 walks while hitting .264. He's slugging .438 with an on-base percentage of .367.
• Including all the qualifying hitters in the big leagues, his batting average ranks 49th, his on-base percentage ranks 13th, and he is 69th in slugging.
• Manny Machado has collected 159 hits to pace his team. He has a batting average of .277 while slugging .464 with an on-base percentage of .338.
• Including all qualifying hitters, he is 27th in batting average, 54th in on-base percentage and 42nd in slugging percentage.
• Luis Arraez has a team-high .386 slugging percentage.
• Ramon Laureano is batting .286 with 24 doubles, two triples, 23 home runs and 33 walks.

Mets vs Padres Head to Head

• 7/30/2025: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/29/2025: 7-1 SD (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/28/2025: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/25/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/24/2024: 7-1 NYM (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/23/2024: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/22/2024: 8-3 NYM (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/16/2024: 11-6 NYM (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/15/2024: 5-1 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/9/2023: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!