Mariners vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 4:15 a.m.

The Seattle Mariners versus the Chicago White Sox is on the MLB schedule for Wednesday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Mariners vs White Sox Game Info

• Seattle Mariners (27-20) vs. Chicago White Sox (15-34)
• Date: Wednesday, May 21, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and ROOT Sports NW

Mariners vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-180) | CHW: (+152)
• Spread: SEA: -1.5 (-110) | CHW: +1.5 (-110)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Mariners vs White Sox Probable Starting Pitchers

Probable Pitchers: Logan Evans (Mariners) - 2-1, 4.71 ERA vs Shane Smith (White Sox) - 1-3, 2.05 ERA

This contest's pitching matchup is set, as the Mariners will send Logan Evans (2-1) to the mound, while Shane Smith (1-3) will take the ball for the White Sox. Evans' team is 1-3-0 against the spread this season in his starts. Evans' team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have gone 3-6-0 against the spread when Smith starts. The White Sox have a 1-7 record in Smith's eight starts this season when they were the underdog on the moneyline.

Mariners vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (62.4%)

Mariners vs White Sox Moneyline

• Looking at the moneyline for White Sox-Mariners, Chicago is the underdog at +152, and Seattle is -180 playing on the road.

Mariners vs White Sox Spread

• The White Sox are +1.5 on the run line against the Mariners. The White Sox are -110 to cover, and the Mariners are -110.

Mariners vs White Sox Over/Under

• An over/under of 8.5 has been set for Mariners-White Sox on May 21, with the over being -106 and the under -114.

Bet on Seattle Mariners vs. Chicago White Sox on FanDuel today!

Mariners vs White Sox Betting Trends

• The Mariners have won in 16, or 59.3%, of the 27 contests they have been named as odds-on favorites in this year.
• This season Seattle has been victorious four times in six chances when named as a favorite of at least -180 on the moneyline.
• Contests with the Mariners have gone over the total set by bookmakers in 25 of 46 chances this season.
• The Mariners have an against the spread record of 24-22-0 in 46 games with a line this season.
• The White Sox have won 28.3% of the games this season they were the moneyline underdog (13-33).
• In games it has played as a moneyline underdog with odds of +152 or longer, Chicago has a 6-24 record (winning only 20% of its games).
• The White Sox have had an over/under set by oddsmakers 47 times, and have combined with opponents to go over the total in 21 of those games (21-23-3).
• The White Sox have gone 23-24-0 ATS this season.

Mariners Player Leaders

• Cal Raleigh has 41 hits, which is tops among Seattle hitters this season, while batting .241 with 24 extra-base hits. He has an on-base percentage of .360 and a slugging percentage of .559.
• Among all qualified batters, he is 103rd in batting average, his on-base percentage ranks 44th, and he is 10th in slugging.
• Julio Rodriguez has hit eight homers this season while driving in 25 runs. He's batting .232 this season and slugging .405 with an on-base percentage of .311.
• He ranks 116th in batting average, 107th in on-base percentage and 91st in slugging among qualified batters.
• Jorge Polanco has 37 hits this season and has a slash line of .306/.351/.603.
• J.P. Crawford leads Seattle with an OBP of .390 this season while batting .274 with 29 walks and 20 runs scored.
• Crawford brings a three-game hitting streak into this game. During his last five outings he is hitting .294 with a double, a home run, six walks and an RBI.

White Sox Player Leaders

• Miguel Vargas has a team-best OBP (.319), and leads the White Sox in hits (40). He's batting .240 and slugging.
• Including all qualifying players in the big leagues, he is 106th in batting average, 97th in on-base percentage and 90th in slugging percentage.
• Luis Robert is hitting .182 with four doubles, five home runs and 21 walks. He's slugging .302 with an on-base percentage of .276.
• He ranks 159th in batting average, 140th in on-base percentage and 159th in slugging percentage in MLB.
• Chase Meidroth is hitting .295 with three doubles, a home run and 12 walks.
• Lenyn Sosa's .380 slugging percentage paces his team.

Mariners vs White Sox Head to Head

• 5/19/2025: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/28/2024: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/27/2024: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/26/2024: 10-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/13/2024: 3-2 CHW (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/12/2024: 2-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 6/11/2024: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/10/2024: 8-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/23/2023: 5-4 CHW (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/22/2023: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!