Mariners vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 1:13 p.m.

MLB action on Wednesday includes the Seattle Mariners facing the Chicago White Sox.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs White Sox Game Info

• Seattle Mariners (27-20) vs. Chicago White Sox (15-34)
• Date: Wednesday, May 21, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and ROOT Sports NW

Mariners vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-180) | CHW: (+152)
• Spread: SEA: -1.5 (-110) | CHW: +1.5 (-110)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Mariners vs White Sox Probable Starting Pitchers

Probable Pitchers: Logan Evans (Mariners) - 2-1, 4.71 ERA vs Shane Smith (White Sox) - 1-3, 2.05 ERA

The Mariners will give the nod to Logan Evans (2-1, 4.71 ERA), who is eyeing win No. 3 on the season, and the White Sox will turn to Shane Smith (1-3, 2.05 ERA). Evans' team is 1-3-0 against the spread in his starts this season. Evans' team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have a 3-6-0 ATS record in Smith's nine starts that had a set spread. The White Sox are 1-7 in Smith's eight starts this season that they were the moneyline underdog.

Mariners vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (61.5%)

Mariners vs White Sox Moneyline

• Looking at the moneyline for Mariners-White Sox, Seattle is the favorite at -180, and Chicago is +152 playing at home.

Mariners vs White Sox Spread

• The Mariners are at the White Sox and are favored by 1.5 runs on the spread. The Mariners are -110 to cover the runline, with the White Sox being -110.

Mariners vs White Sox Over/Under

• The over/under for Mariners-White Sox on May 21 is 8.5. The over is -106, and the under is -114.

Bet on Seattle Mariners vs. Chicago White Sox on FanDuel today!

Mariners vs White Sox Betting Trends

• The Mariners have been favorites in 27 games this season and have come away with the win 16 times (59.3%) in those contests.
• Seattle has a record of 4-2 when favored by -180 or more this year.
• The Mariners and their opponents have gone over the total this season in 25 of their 46 opportunities.
• The Mariners are 24-22-0 against the spread in their 46 games with a line set by sportsbooks this season.
• The White Sox have won 28.3% of the games this season they were the moneyline underdog (13-33).
• When it has played as a moneyline underdog with odds of +152 or longer, Chicago has a record of 6-24 (20%).
• The White Sox have combined with opponents to go over the total 21 times this season for a 21-23-3 record against the over/under.
• The White Sox have collected a 23-24-0 record against the spread this season.

Mariners Player Leaders

• Cal Raleigh has 41 hits, which leads Seattle hitters this season, while batting .241 with 24 extra-base hits. He has an on-base percentage of .360 and a slugging percentage of .559.
• He ranks 103rd in batting average, 44th in on-base percentage, and 10th in slugging among qualifying batters in MLB.
• Julio Rodriguez has an OPS of .717, fueled by an OBP of .311 and a team-best slugging percentage of .405 this season. He's batting .232.
• He ranks 116th in batting average, 107th in on-base percentage and 91st in slugging among qualifying hitters.
• Jorge Polanco has collected 37 base hits, an OBP of .351 and a slugging percentage of .603 this season.
• J.P. Crawford has 43 hits this season and a team-best OBP of .390.
• Crawford has safely hit in three games in a row. During his last five outings he is hitting .294 with a double, a home run, six walks and an RBI.

White Sox Player Leaders

• Miguel Vargas has a team-high OBP (.319), while pacing the White Sox in hits (40). He's batting .240 and slugging.
• Including all qualified hitters in MLB, he is 106th in batting average, 97th in on-base percentage and 90th in slugging percentage.
• Luis Robert is batting .182 with four doubles, five home runs and 21 walks. He's slugging .302 with an on-base percentage of .276.
• Including all qualified players, his batting average places him 159th, his on-base percentage ranks 140th, and he is 159th in slugging.
• Chase Meidroth is hitting .295 with three doubles, a home run and 12 walks.
• Lenyn Sosa is slugging .380 to pace his team.

Mariners vs White Sox Head to Head

• 5/19/2025: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/28/2024: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/27/2024: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/26/2024: 10-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/13/2024: 3-2 CHW (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/12/2024: 2-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 6/11/2024: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/10/2024: 8-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/23/2023: 5-4 CHW (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/22/2023: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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