Mariners vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 5:11 a.m.

The Seattle Mariners versus the San Diego Padres is on the MLB schedule for Saturday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Mariners vs Padres Game Info

• Seattle Mariners (22-24) vs. San Diego Padres (26-18)
• Date: Saturday, May 16, 2026
• Time: 7:15 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: FOX

Mariners vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-134) | SD: (+114)
• Spread: SEA: -1.5 (+158) | SD: +1.5 (-192)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Mariners vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 2-3, 3.78 ERA vs Walker Buehler (Padres) - 2-2, 5.20 ERA

The Mariners will look to Logan Gilbert (2-3) versus the Padres and Walker Buehler (2-2). Gilbert and his team are 2-7-0 ATS this season when he starts. When Gilbert starts a game and his team is the favorite on the moneyline, they have a record of 4-3. When Buehler starts, the Padres are 5-3-0 against the spread. The Padres have been the underdog on the moneyline in four of Buehler's starts this season, and they went 3-1 in those matchups.

Mariners vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (61.8%)

Mariners vs Padres Moneyline

• San Diego is a +114 underdog on the moneyline, while Seattle is a -134 favorite at home.

Mariners vs Padres Spread

• The Mariners are favored by 1.5 runs at home versus the Padres. The Mariners are +158 to cover the spread, while the Padres are -192.

Mariners vs Padres Over/Under

• A total of 7.5 runs has been set for the Mariners-Padres game on May 16, with the over available at +102 and the under at -124.

Bet on Seattle Mariners vs. San Diego Padres on FanDuel today!

Mariners vs Padres Betting Trends

• The Mariners have come away with 21 wins in the 42 contests they have been listed as the favorites in this season.
• This year Seattle has won 18 of 31 games when listed as at least -134 on the moneyline.
• The Mariners and their opponents have gone over in 20 of their 46 games with a total set by sportsbooks this season.
• In 46 games with a line this season, the Mariners have a mark of 17-29-0 against the spread.
• The Padres have won nine of the 17 games they were the moneyline underdog this season (52.9%).
• San Diego has a 4-3 record (winning 57.1% of its games) when playing as a moneyline underdog of +114 or longer.
• The Padres have had an over/under set by oddsmakers 44 times, and have combined with opponents to go over the total in 18 of those games (18-25-1).
• The Padres have collected a 24-20-0 record ATS this season (covering 54.5% of the time).

Mariners Player Leaders

• Randy Arozarena leads Seattle with 51 hits and an OBP of .392, plus a team-best slugging percentage of .455. He's batting .305.
• Among qualifying batters in baseball, his batting average ranks 17th, his on-base percentage ranks 13th, and he is 53rd in slugging.
• Julio Rodriguez has nine doubles, seven home runs and 16 walks. He's batting .257 and slugging .421 with an on-base percentage of .323.
• He ranks 75th in batting average, 100th in on-base percentage and 67th in slugging in the major leagues.
• J.P. Crawford has 28 hits this season and has a slash line of .211/.360/.353.
• Josh Naylor has been key for Seattle with 42 hits, an OBP of .310 plus a slugging percentage of .365.
• Naylor heads into this game on a four-game hitting streak. In his last five games he is batting .190 with a double and two walks.

Padres Player Leaders

• Xander Bogaerts has accumulated 41 hits with a .335 on-base percentage and a .417 slugging percentage, all club-bests for the Padres. He's batting .263.
• Including all the qualified hitters in the big leagues, his batting average ranks 66th, his on-base percentage is 82nd, and he is 70th in slugging.
• Manny Machado is hitting .185 with four doubles, six home runs and 21 walks. He's slugging .331 with an on-base percentage of .280.
• He is currently 163rd in batting average, 148th in on-base percentage and 145th in slugging percentage among all qualified hitters.
• Gavin Sheets has nine doubles, six home runs and 10 walks while hitting .240.
• Jackson Merrill is hitting .210 with eight doubles, four home runs and 15 walks.

Mariners vs Padres Head to Head

• 5/15/2026: 2-0 SD (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 5-2 SD (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/15/2026: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/14/2026: 4-1 SD (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/26/2025: 7-6 SD (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/25/2025: 9-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/18/2025: 6-1 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2025: 4-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/16/2025: 5-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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