Louisiana vs Marshall Prediction, Odds, Picks, Best Bets for Week 5 2025

On Saturday in college football, the Marshall Thundering Herd are up against the Louisiana Ragin' Cajuns.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Marshall vs Louisiana Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Marshall: (-126) | Louisiana: (+105)
• Spread: Marshall: -1.5 (-115) | Louisiana: +1.5 (-105)
• Total: 48.5 -- Over: (-104) | Under: (-118)

Marshall vs Louisiana Betting Trends

• Against the spread, Marshall is 3-1-0 this season.
• As at least a 1.5-point favorite, Marshall has two wins ATS (2-1).
• Two of four Marshall games have gone over the point total this season.
• Louisiana is winless against the spread this season.
• Louisiana has no wins ATS (0-1) as a 1.5-point underdog or greater this season.
• Two Louisiana games (of three) have gone over the point total this year.

Marshall vs Louisiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Thundering Herd win (51.6%)

Marshall vs Louisiana Point Spread

Marshall is a 1.5-point favorite against Louisiana. Marshall is -115 to cover the spread, and Louisiana is -105.

Marshall vs Louisiana Over/Under

A combined point total of 48.5 has been set for Marshall-Louisiana on Sept. 27, with the over at -104 and the under at -118.

Marshall vs Louisiana Moneyline

The Marshall vs Louisiana moneyline has Marshall as a -126 favorite, while Louisiana is a +105 underdog.

Marshall vs. Louisiana Points Insights

Marshall vs. Louisiana Game Info

• Game day: Saturday, September 27, 2025
• Game time: 8 p.m. ET
• TV channel: ESPN+
• Location: Lafayette, Louisiana
• Stadium: Cajun Field at Our Lady of Lourdes Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Marshall vs. Louisiana analysis on FanDuel Research.