Iowa State vs Tennessee State College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament First Round

An opening-round NCAA Tournament matchup will see the No. 2-seed Iowa State Cyclones (27-7) play against the No. 15 seed Tennessee State Tigers (23-9) on Friday at Enterprise Center. The contest tips off at 2:50 p.m. ET, on CBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Tennessee State Game Info and Odds

• Game day: Friday, March 20, 2026
• Game time: 2:50 p.m. ET
• TV channel: CBS
• Location: St. Louis, Missouri
• Arena: Enterprise Center

Iowa State vs. Tennessee State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (90.2%)

Iowa State is a 24.5-point favorite against Tennessee State on Friday and the over/under is set at 148.5 points. Below are some betting insights and trends to help you make an informed wager on the outing.

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Iowa State vs. Tennessee State: ATS Betting Stats and Trends

• Iowa State is 20-14-0 ATS this season.
• Tennessee State is 18-11-0 ATS this season.
• When the spread is set as 24.5 or more this season, Iowa State (3-4) covers a lower percentage of those games when it is the favorite (42.9%) than Tennessee State (1-0) does as the underdog (100%).
• The Cyclones have covered the spread in a higher percentage of their home games than road games. They have covered nine times in 17 opportunities when playing at home, and they've covered five times in 10 opportunities in road games.
• Against the spread, the Tigers have had better results on the road (10-6-0) than at home (5-5-0).

Iowa State vs. Tennessee State: Moneyline Betting Stats

• Iowa State has come away with 22 wins in the 27 contests it has been listed as the moneyline favorite in this season.
• The Cyclones have yet to lose in three games when named as moneyline favorite of -10000 or better.
• Tennessee State has won seven of the 11 games it was the moneyline underdog this season (63.6%).
• The Tigers have never played a game this season with moneyline odds of +2800 or longer.
• The moneyline set for this matchup implies Iowa State has a 99% chance of coming away with a victory in the contest.

Iowa State vs. Tennessee State Head-to-Head Comparison

• Last season, Iowa State was 34th in the nation on offense (80.3 points scored per game) and 61st defensively (68.3 points conceded).
• At 32.7 rebounds per game and 28.3 rebounds allowed, Iowa State was 142nd and 31st in the country, respectively, last year.
• Last season Iowa State was ranked 77th in the nation in assists with 15 per game.
• Last season, Iowa State was 232nd in the nation in turnovers committed (11.6 per game) and 13th-best in turnovers forced (14.4).
• Tennessee State ranked 73rd in the country last season with 78.1 points per game. At the other end of the court, it ranked 219th with 73.3 points allowed per game.
• Tennessee State ranked sixth-best in the nation by grabbing 37.5 rebounds per game. In terms of rebounds allowed, it ranked 164th in college basketball (30.9 allowed per contest).
• Tennessee State delivered 13.3 assists per game, which ranked them 203rd in the country.
• While Tennessee State was in the bottom 25 in the nation in turnovers per game with 14.5 (second-worst), it ranked 93rd in college basketball with 12.2 forced turnovers per contest.

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