Iowa State vs Kentucky College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 2 seed Iowa State Cyclones (28-7) attempt to earn a trip to the Sweet 16 in an NCAA Tournament Round of 32 matchup against the No. 7 seed Kentucky Wildcats (22-13) on Sunday at Enterprise Center, tipping off at 2:45 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Kentucky Game Info and Odds

• Game day: Sunday, March 22, 2026
• Game time: 2:45 p.m. ET
• TV channel: CBS
• Location: St. Louis, Missouri
• Arena: Enterprise Center

Iowa State vs. Kentucky Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (70.6%)

Before placing a bet on Sunday's Iowa State-Kentucky spread (Iowa State -4.5) or over/under (146.5 points), see the betting trends and insights below.

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Iowa State vs. Kentucky: ATS Betting Stats and Trends

• Iowa State has won 21 games against the spread this season, while failing to cover 14 times.
• Kentucky has covered 18 times in 35 games with a spread this year.
• When the spread is set as 4.5 or more this season, Iowa State (18-10) covers a higher percentage of those games when it is the favorite (64.3%) than Kentucky (4-5) does as the underdog (44.4%).
• The Cyclones have covered the spread in a higher percentage of their home games than away games. They have covered nine times in 17 opportunities at home, and they've covered five times in 10 opportunities in away games.
• The Wildcats have the same winning percentage against the spread (.500) at home (9-9-0 record) and away (5-5-0) this year.

Iowa State vs. Kentucky: Moneyline Betting Stats

• Iowa State has been the moneyline favorite in 28 games this season and has come away with the win 23 times (82.1%) in those contests.
• The Cyclones have a win-loss record of 20-3 when favored by -220 or better by oddsmakers this year.
• Kentucky has gone 2-9 in games it was listed as the moneyline underdog (winning 18.2% of those games).
• The Wildcats have a 2-7 record (winning just 22.2% of their games) when they have played as a moneyline underdog of +180 or longer.
• Sportsbooks have implied with the moneyline set for this matchup that Iowa State has a 68.8% chance of pulling out a win.

Iowa State vs. Kentucky Head-to-Head Comparison

• Iowa State averages 82.5 points per game (46th in college basketball) while giving up 65.4 per contest (13th in college basketball). It has a +600 scoring differential overall and outscores opponents by 17.1 points per game.
• Milan Momcilovic's team-leading 17.1 points per game ranks 146th in the country.
• Kentucky is outscoring opponents by 6.9 points per game, with a +241 scoring differential overall. It puts up 81 points per game (65th in college basketball) and gives up 74.1 per outing (187th in college basketball).
• Otega Oweh leads Kentucky, scoring 18.7 points per game (67th in college basketball).
• The 32.5 rebounds per game the Cyclones average rank 141st in college basketball, and are 4.1 more than the 28.4 their opponents grab per outing.
• Joshua Jefferson averages 7.4 rebounds per game (ranking 112th in college basketball) to lead the Cyclones.
• The Wildcats win the rebound battle by three boards on average. They collect 34.1 rebounds per game, 70th in college basketball, while their opponents grab 31.1.
• Malachi Moreno averages 6.3 rebounds per game (243rd in college basketball) to lead the Wildcats.
• Iowa State averages 106.9 points per 100 possessions (18th in college basketball), while giving up 84.7 points per 100 possessions (seventh in college basketball).
• The Wildcats' 102.4 points per 100 possessions on offense rank 69th in college basketball, and the 93.7 points they concede per 100 possessions rank 132nd in college basketball.

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