Diamondbacks vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 19

Odds updated as of 5:11 a.m.

In MLB action on Tuesday, the Arizona Diamondbacks take on the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (23-23) vs. San Francisco Giants (20-28)
• Date: Tuesday, May 19, 2026
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and NBCS-BA

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-124) | SF: (+106)
• Spread: ARI: +1.5 (-210) | SF: -1.5 (+172)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Ryne Nelson (Diamondbacks) - 1-3, 5.40 ERA vs Landen Roupp (Giants) - 5-4, 3.49 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Ryne Nelson (1-3) to the mound, while Landen Roupp (5-4) will get the nod for the Giants. When Nelson starts, his team is 3-6-0 against the spread this season. Nelson's team lost his only start as a favorite this season. The Giants have a 4-5-0 record against the spread in Roupp's starts. The Giants have a 4-2 record in Roupp's six starts this season when they were the moneyline underdog.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (52.4%)

Diamondbacks vs Giants Moneyline

• Arizona is the favorite, -124 on the moneyline, while San Francisco is a +106 underdog on the road.

Diamondbacks vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Giants are +172 to cover, while the Diamondbacks are -210 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Giants Over/Under

• A combined run total of 8.5 has been set for Diamondbacks-Giants on May 19, with the over at -120 and the under at -102.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have been favorites in 16 games this season and have come away with the win 10 times (62.5%) in those contests.
• This season Arizona has come away with a win five times in eight chances when named as a favorite of at least -124 on the moneyline.
• The Diamondbacks and their opponents have hit the over in 23 of their 45 games with a total set by oddsmakers this season.
• The Diamondbacks have posted a record of 27-18-0 against the spread this season.
• The Giants have a 13-21 record in games they were listed as the moneyline underdog (winning 38.2% of those games).
• San Francisco is 10-13 (winning 43.5% of its games) when it has played as a moneyline underdog of +106 or longer.
• The Giants have played in 48 games with a set over/under, and have combined with opponents to go over the total 21 times (21-24-3).
• The Giants have a 20-28-0 record ATS this season (covering 41.7% of the time).

Diamondbacks Player Leaders

• Ildemaro Vargas leads Arizona with a slugging percentage of .544, fueled by 17 extra-base hits. He has a .335 batting average and an on-base percentage of .356.
• Among all qualifying batters in baseball, he is second in batting average, 49th in on-base percentage, and 14th in slugging.
• Vargas has hit safely in two straight games. During his last five outings he is batting .333 with a double and five RBIs.
• Corbin Carroll leads the Diamondbacks in OBP (.392) and total hits (44) this season. He's batting .284 while slugging .555.
• He ranks 33rd in batting average, 14th in on-base percentage and 11th in slugging among qualifying hitters.
• Carroll brings a seven-game streak with at least one hit into this contest. During his last 10 games he is hitting .353 with four doubles, a triple, two home runs, nine walks and four RBIs.
• Nolan Arenado is batting .272 with a .463 slugging percentage and 25 RBI this year.
• Arenado has recorded a hit in two straight games. In his last five games he is batting .313 with three doubles, a home run, five walks and seven RBIs.
• Geraldo Perdomo is batting .227 with a .344 OBP and 12 RBI for Arizona this season.
• Perdomo brings a four-game hitting streak into this matchup. During his last five outings he is hitting .250 with a double and five walks.

Giants Player Leaders

• Luis Arraez has put up an on-base percentage of .365 and a slugging percentage of .432. Both lead the Giants. He's batting .324.
• Including all qualified hitters in the majors, his batting average places him sixth, his on-base percentage is 38th, and he is 63rd in slugging.
• Jung Hoo Lee is batting .268 with 10 doubles, a triple, three home runs and 10 walks. He's slugging .385 with an on-base percentage of .311.
• Including all qualified hitters, he is 50th in batting average, 113th in on-base percentage and 103rd in slugging percentage.
• Casey Schmitt has racked up 44 hits, a team-best for the Giants.
• Rafael Devers is batting .240 with 10 doubles, five home runs and 13 walks.

Diamondbacks vs Giants Head to Head

• 5/18/2026: 12-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/17/2025: 5-1 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/16/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!