Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 17

Odds updated as of 6:11 p.m.

Saturday's slate in the MLB includes a matchup between the Cleveland Guardians and the Cincinnati Reds.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Reds Game Info

• Cleveland Guardians (25-19) vs. Cincinnati Reds (22-24)
• Date: Saturday, May 17, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and CLEG

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | CIN: (-102)
• Spread: CLE: -1.5 (+128) | CIN: +1.5 (-154)
• Total: 10 -- Over: (-104) | Under: (-118)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 0-0, 0.00 ERA vs Brent Suter (Reds) - 1-0, 2.08 ERA

This contest's pitching matchup is set, as the Guardians will send Slade Cecconi to the mound, while Brent Suter (1-0) will take the ball for the Reds. In games Cecconi pitched with a spread last season, his team was 5-8-0 ATS. Cecconi appeared in five games last season as the moneyline favorite and his team finished with a record of 1-4 in those contests. Suter has started just one game with a set spread, which the Reds covered. The Reds were the underdog on the moneyline for one Suter start this season -- they won.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (62.2%)

Guardians vs Reds Moneyline

• Looking at the moneyline for Reds-Guardians, Cincinnati is the underdog at -102, and Cleveland is -116 playing on the road.

Guardians vs Reds Spread

• The Guardians are favored by 1.5 runs on the road versus the Reds. The Guardians are +128 to cover the spread, while the Reds are -154.

Guardians vs Reds Over/Under

• Guardians versus Reds on May 17 has an over/under of 10 runs, with the odds on the over -104 and the under set at -118.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have been chosen as favorites in 17 games this year and have walked away with the win 11 times (64.7%) in those games.
• This season Cleveland has come away with a win 10 times in 15 chances when named as a favorite of at least -116 on the moneyline.
• Contests with the Guardians have gone over the total set by oddsmakers in 22 of 43 chances this season.
• The Guardians are 20-23-0 against the spread in their 43 games with a line set by sportsbooks this season.
• The Reds have won 44% of the games this season they were the underdog on the moneyline (11-14).
• Cincinnati is 10-12 (winning 45.5% of its games) when playing as a moneyline underdog of -102 or longer.
• In the 44 games bookmakers have set an over/under for the Reds, they have combined with opponents to go over the total 18 times (18-25-1).
• The Reds have covered 52.3% of their games this season, going 23-21-0 ATS.

Guardians Player Leaders

• Jose Ramirez has 45 hits, which is tops among Cleveland hitters this season, while batting .294 with 17 extra-base hits. He has an on-base percentage of .360 and a slugging percentage of .523.
• He ranks 25th in batting average, 46th in on-base percentage, and 19th in slugging among qualified hitters in MLB.
• Ramirez will look for his 11th straight game with a hit in this contest. In his last 10 outings he is batting .389 with three doubles, four home runs, six walks and eight RBIs.
• Steven Kwan has a slash line of .320/.381/.442 this season and a team-best OPS of .823.
• He is eighth in batting average, 24th in on-base percentage and 62nd in slugging among qualifying batters.
• Kyle Manzardo is batting .222 with a .504 slugging percentage and 25 RBI this year.
• Manzardo heads into this game with four games in a row with at least one hit. During his last five outings he is batting .278 with a double, a triple, a home run and three RBIs.
• Carlos Santana is batting .221 with a .329 OBP and 21 RBI for Cleveland this season.

Reds Player Leaders

• Elly De La Cruz has accumulated a team-best slugging percentage (.425) and leads the Reds in hits (46). He's batting .257 and with an on-base percentage of .330.
• He is 78th in batting average, 79th in on-base percentage and 72nd in slugging percentage among all qualified hitters in the majors.
• De La Cruz takes a four-game hitting streak into this game. During his last five outings he is hitting .316 with a double, two home runs, a walk and two RBIs.
• TJ Friedl is batting .269 with six doubles, a triple, three home runs and 21 walks. He's slugging .375 with an on-base percentage of .357.
• Including all qualifying players, he ranks 56th in batting average, 50th in on-base percentage and 113th in slugging percentage.
• Gavin Lux has a team-high .386 on-base percentage.
• Matt McLain has three doubles, six home runs and 21 walks while batting .184.

Guardians vs Reds Head to Head

• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/11/2024: 5-3 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/27/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/26/2023: 11-7 CIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/16/2023: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/15/2023: 3-0 CLE (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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