Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 17

Odds updated as of 6:11 a.m.

In MLB action on Saturday, the Cleveland Guardians face the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Reds Game Info

• Cleveland Guardians (25-19) vs. Cincinnati Reds (22-24)
• Date: Saturday, May 17, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and CLEG

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | CIN: (+108)
• Spread: CLE: -1.5 (+116) | CIN: +1.5 (-140)
• Total: 10 -- Over: (-105) | Under: (-115)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 0-0, 0.00 ERA vs Brent Suter (Reds) - 1-0, 2.08 ERA

The probable starters are Slade Cecconi for the Guardians and Brent Suter (1-0) for the Reds. In games Cecconi pitched with a spread last season, his team was 5-8-0 ATS. Cecconi and his team had a 1-4 record when he pitched as a favorite last season. Suter has started only one game with a set spread, which the Reds covered. The Reds were the moneyline underdog for one Suter start this season -- they won.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (53.9%)

Guardians vs Reds Moneyline

• Cincinnati is the underdog, +108 on the moneyline, while Cleveland is a -126 favorite despite being on the road.

Guardians vs Reds Spread

• The Guardians are favored by 1.5 runs on the road versus the Reds. The Guardians are +116 to cover the spread, while the Reds are -140.

Guardians vs Reds Over/Under

• The Guardians-Reds contest on May 17 has been given an over/under of 10 runs. The over is set at -105 and the under at -115.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have been victorious in 11, or 64.7%, of the 17 contests they have been chosen as favorites in this season.
• Cleveland has a record of 6-1 in contests when oddsmakers favor them by -126 or more on the moneyline.
• The Guardians and their opponents have hit the over in 22 of their 43 games with a total set by oddsmakers this season.
• In 43 games with a line this season, the Guardians have a mark of 20-23-0 against the spread.
• The Reds have won 11 of the 25 games they were listed as the moneyline underdog this season (44%).
• When playing as a moneyline underdog with odds of +108 or longer, Cincinnati has a 5-8 record (winning just 38.5% of its games).
• The Reds have played in 44 games with an over/under set, and have combined with their opponents to go over the total 18 times (18-25-1).
• The Reds have covered 52.3% of their games this season, going 23-21-0 ATS.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 45 hits, batting .294 this season with 17 extra-base hits. He has an on-base percentage of .360 and a slugging percentage of .523.
• Among qualifying hitters in MLB, he is 25th in batting average, 45th in on-base percentage, and 19th in slugging.
• Ramirez hopes to build on a 10-game hitting streak in this matchup. During his last 10 games he is hitting .389 with three doubles, four home runs, six walks and eight RBIs.
• Steven Kwan has a slash line of .320/.381/.442 this season and a team-best OPS of .823.
• Among all qualifying players, he is eighth in batting average, 24th in on-base percentage and 62nd in slugging percentage.
• Kyle Manzardo has 30 hits this season and has a slash line of .222/.312/.504.
• Manzardo has recorded at least one base hit in four games in a row. During his last five outings he is hitting .278 with a double, a triple, a home run and three RBIs.
• Carlos Santana has four home runs, 21 RBI and a batting average of .221 this season.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .425 and has 46 hits, both team-high numbers for the Reds. He's batting .257 and with an on-base percentage of .330.
• He is 80th in batting average, 79th in on-base percentage and 73rd in slugging percentage among all qualifying hitters in MLB.
• De La Cruz hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .316 with a double, two home runs, a walk and two RBIs.
• TJ Friedl has six doubles, a triple, three home runs and 21 walks while hitting .269. He's slugging .375 with an on-base percentage of .357.
• He ranks 58th in batting average, 51st in on-base percentage and 114th in slugging percentage in the majors.
• Gavin Lux has accumulated an on-base percentage of .386, a team-high for the Reds.
• Matt McLain is batting .184 with three doubles, six home runs and 21 walks.

Guardians vs Reds Head to Head

• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/11/2024: 5-3 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/27/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/26/2023: 11-7 CIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/16/2023: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/15/2023: 3-0 CLE (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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