Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 5:11 p.m.

MLB action on Saturday includes the Cleveland Guardians taking on the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this game.

Guardians vs Reds Game Info

• Cleveland Guardians (24-22) vs. Cincinnati Reds (24-21)
• Date: Saturday, May 16, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Reds.TV

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-156) | CIN: (+132)
• Spread: CLE: -1.5 (+128) | CIN: +1.5 (-154)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 3-1, 2.98 ERA vs Chris Paddack (Reds) - 0-5, 7.63 ERA

The Guardians will give the ball to Joey Cantillo (3-1, 2.98 ERA), who is eyeing win No. 4 on the season, and the Reds will counter with Chris Paddack (0-5, 7.63 ERA). Cantillo and his team are 7-2-0 ATS this season when he starts. Cantillo's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. The Reds have gone 1-5-0 ATS in Paddack's six starts with a set spread. The Reds were the underdog on the moneyline for four Paddack starts this season -- they lost all of the games.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.6%)

Guardians vs Reds Moneyline

• The moneyline numbers for Guardians vs. Reds reveal Cleveland as the favorite (-156) and Cincinnati as the underdog (+132) on the road.

Guardians vs Reds Spread

• The Guardians are hosting the Reds and are favored by 1.5 runs (+128 to cover) on the runline. Cincinnati is -154 to cover.

Guardians vs Reds Over/Under

• Guardians versus Reds, on May 16, has an over/under of 8.5, with the over being -105 and the under -115.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have been victorious in 12, or 52.2%, of the 23 contests they have been chosen as favorites in this season.
• This season Cleveland has come away with a win two times in four chances when named as a favorite of at least -156 on the moneyline.
• The Guardians and their opponents have gone over in 23 of their 44 games with a total set by sportsbooks this season.
• The Guardians are 23-21-0 against the spread in their 44 games with a line set by sportsbooks this season.
• The Reds have compiled a 15-11 record in games they were listed as the moneyline underdog (winning 57.7% of those games).
• Cincinnati is 2-4 (winning just 33.3% of its games) when it has played as a moneyline underdog of +132 or longer.
• The Reds have combined with opponents to hit the over on the total 27 times this season for a 27-15-1 record against the over/under.
• The Reds have a 26-17-0 record against the spread this season (covering 60.5% of the time).

Guardians Player Leaders

• Jose Ramirez is hitting .220 with nine doubles, six home runs and 32 walks. He has an on-base percentage of .347 while slugging .381.
• Among all qualifying hitters in baseball, his batting average ranks 130th, his on-base percentage ranks 65th, and he is 105th in slugging.
• Chase DeLauter has 42 hits and an OBP of .371 to go with a slugging percentage of .490. All three of those stats lead Cleveland hitters this season. He's batting .286.
• His batting average ranks 32nd among qualified players, his on-base percentage 33rd, and his slugging percentage 33rd.
• Brayan Rocchio has 39 hits this season and has a slash line of .269/.348/.366.
• Angel Martinez has been key for Cleveland with 35 hits, an OBP of .303 plus a slugging percentage of .467.
• Martinez heads into this game on a four-game hitting streak. During his last five outings he is batting .250 with two home runs, a walk and four RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up an on-base percentage of .360, a slugging percentage of .525, and has 54 hits, all club-highs for the Reds (while batting .298).
• Including all qualified hitters in MLB, he is 21st in batting average, 45th in on-base percentage and 17th in slugging percentage.
• De La Cruz heads into this game on an eight-game hitting streak. During his last 10 games he is batting .341 with five doubles and five RBIs.
• Sal Stewart is batting .238 with eight doubles, 10 home runs and 23 walks. He's slugging .459 with an on-base percentage of .325.
• He is 104th in batting average, 96th in on-base percentage and 51st in slugging percentage in the majors.
• Spencer Steer is batting .263 with seven doubles, seven home runs and 14 walks.
• Matt McLain is batting .217 with eight doubles, five home runs and 23 walks.

Guardians vs Reds Head to Head

• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)

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