Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 7:11 p.m.

The Saturday slate in MLB includes a matchup between the Chicago White Sox and the Chicago Cubs.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

White Sox vs Cubs Game Info

• Chicago White Sox (22-22) vs. Chicago Cubs (29-16)
• Date: Saturday, May 16, 2026
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MARQ

White Sox vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-108) | CHC: (-108)
• Spread: CHW: +1.5 (-184) | CHC: -1.5 (+150)
• Total: 8.5 -- Over: (-110) | Under: (-110)

White Sox vs Cubs Probable Starting Pitchers

Probable Pitchers: Davis Martin (White Sox) - 5-1, 1.62 ERA vs Jameson Taillon (Cubs) - 2-2, 3.94 ERA

The White Sox will give the nod to Davis Martin (5-1, 1.62 ERA), who is eyeing win No. 6 on the season, and the Cubs will turn to Jameson Taillon (2-2, 3.94 ERA). Martin's team is 7-1-0 against the spread this season in his starts. This will be Martin's first start this season with his team as the moneyline favorite. The Cubs have gone 2-6-0 ATS in Taillon's eight starts with a set spread. The Cubs have a 2-2 record in Taillon's four starts this season when they were the moneyline underdog.

White Sox vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (64.5%)

White Sox vs Cubs Moneyline

• The White Sox vs Cubs moneyline has the White Sox as a -108 favorite, while the Cubs are a -108 underdog on the road.

White Sox vs Cubs Spread

White Sox vs Cubs Over/Under

• A total of 8.5 runs has been set for the White Sox-Cubs contest on May 16, with the over available at -110 and the under at -110.

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White Sox vs Cubs Betting Trends

• The White Sox have been chosen as favorites in four games this year and have walked away with the win one time (25%) in those games.
• This season, the White Sox have come away with a win one time in four chances when named as a favorite of at least -108 or shorter on the moneyline.
• The White Sox and their opponents have hit the over in 23 of their 42 games with a total this season.
• In 42 games with a line this season, the White Sox have a mark of 24-18-0 against the spread.
• The Cubs have been the moneyline underdog 15 total times this season. They've finished 8-7 in those games.
• The Cubs have a record of 8-7 when they have played as a moneyline underdog with odds of -108 or longer (53.3%).
• The Cubs have played in 44 games with a set over/under, and have combined with their opponents to go over the total 25 times (25-19-0).
• The Cubs have collected a 21-23-0 record ATS this season (covering 47.7% of the time).

White Sox Player Leaders

• Miguel Vargas leads Chicago with an OBP of .376 this season while batting .247 with 30 walks and 32 runs scored. He has a slugging percentage of .494.
• Among qualified hitters in baseball, he is 91st in batting average, 29th in on-base percentage, and 29th in slugging.
• Vargas will look for his eighth straight game with a hit in this contest. During his last 10 games he is batting .333 with two doubles, four home runs, six walks and seven RBIs.
• Munetaka Murakami leads Chicago with 35 hits. He is batting .227 this season and has 16 extra-base hits. He's also slugging .526 with an on-base percentage of .368.
• Among qualified batters, his batting average ranks him 122nd, his on-base percentage 38th, and his slugging percentage 16th.
• Colson Montgomery is batting .237 with a .519 slugging percentage and 30 RBI this year.
• Montgomery has picked up a hit in two straight games. During his last five outings he is hitting .316 with three home runs, a walk and four RBIs.
• Chase Meidroth leads Chicago with a slugging percentage of .394, fueled by 12 extra-base hits.

Cubs Player Leaders

• Nico Hoerner has a .399 slugging percentage, which paces the Cubs. He's batting .264 with an on-base percentage of .340.
• Including all qualifying players, he ranks 64th in batting average, while his on-base percentage is 74th and he is 86th in slugging.
• Ian Happ leads his team with 38 hits and a .381 OBP. He has a batting average of .241 while slugging .481.
• He ranks 101st in batting average, 20th in on-base percentage and 36th in slugging percentage in the majors.
• Dansby Swanson has four doubles, a triple, six home runs and 23 walks while hitting .189.
• Alex Bregman has five doubles, a triple, four home runs and 23 walks while batting .250.

White Sox vs Cubs Head to Head

• 5/15/2026: 10-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/27/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/26/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/25/2025: 12-5 CHW (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 5/18/2025: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/17/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 10, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)

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