Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 15

Odds updated as of 7:11 p.m.

In MLB action on Friday, the Cleveland Guardians take on the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Reds Game Info

• Cleveland Guardians (24-21) vs. Cincinnati Reds (23-21)
• Date: Friday, May 15, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Reds.TV

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-136) | CIN: (+116)
• Spread: CLE: -1.5 (+160) | CIN: +1.5 (-194)
• Total: 8 -- Over: (-108) | Under: (-112)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-5, 4.17 ERA vs Andrew Abbott (Reds) - 2-2, 4.47 ERA

The Guardians will look to Tanner Bibee (0-5) versus the Reds and Andrew Abbott (2-2). Bibee and his team are 1-7-0 ATS this season when he starts. Bibee and his team have lost each of the four games he's started as the moneyline favorite. The Reds have gone 6-3-0 against the spread when Abbott starts. The Reds have been the underdog on the moneyline in six of Abbott's starts this season, and they went 3-3 in those games.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.4%)

Guardians vs Reds Moneyline

• Cincinnati is the underdog, +116 on the moneyline, while Cleveland is a -136 favorite at home.

Guardians vs Reds Spread

• The Guardians are hosting the Reds and are favored by 1.5 runs on the spread. The Guardians are +160 to cover the runline, with the Reds being -194.

Guardians vs Reds Over/Under

• Guardians versus Reds, on May 15, has an over/under of 8, with the over being -108 and the under -112.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have been victorious in 12, or 54.5%, of the 22 contests they have been chosen as favorites in this season.
• This season Cleveland has come away with a win five times in eight chances when named as a favorite of at least -136 on the moneyline.
• The Guardians and their opponents have hit the over in 22 of their 43 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 23-20-0 against the spread this season.
• The Reds have been the underdog on the moneyline 25 total times this season. They've gone 14-11 in those games.
• Cincinnati has a record of 4-6 in games it has played as a moneyline underdog with odds of +116 or longer (40%).
• The Reds have played in 42 games with a set over/under, and have combined with their opponents to go over the total 26 times (26-15-1).
• The Reds have collected a 25-17-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez is hitting .207 with eight doubles, six home runs and 32 walks. He has an on-base percentage of .340 and a slugging percentage of .366.
• Among all qualifying hitters, he is 146th in batting average, his on-base percentage ranks 72nd, and he is 115th in slugging.
• Chase DeLauter has 42 hits and an OBP of .376 to go with a slugging percentage of .503. All three of those stats are best among Cleveland hitters this season. He's batting .294.
• His batting average is 25th among qualified players, his on-base percentage 27th, and his slugging percentage 25th.
• Brayan Rocchio has 39 hits this season and has a slash line of .275/.350/.373.
• Angel Martinez has seven home runs, 19 RBI and a batting average of .260 this season.
• Martinez takes a three-game hitting streak into this game. During his last five outings he is batting .200 with two home runs and three RBIs.

Reds Player Leaders

• Sal Stewart is hitting .244 with eight doubles, 10 home runs and 22 walks. He's slugging .470 with an on-base percentage of .328.
• Including all the qualified hitters in the big leagues, his batting average puts him 97th, his on-base percentage is 91st, and he is 48th in slugging.
• Elly De La Cruz has collected 53 hits with a .359 OBP while slugging .525. Those stats all pace his team. He also has a batting average of .299.
• Including all qualified hitters, his batting average puts him 20th, his on-base percentage ranks 47th, and he is 15th in slugging.
• Spencer Steer is batting .259 with seven doubles, seven home runs and 14 walks.
• Matt McLain is hitting .208 with eight doubles, four home runs and 22 walks.

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