Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 15

Odds updated as of 2:11 a.m.

In MLB action on Friday, the Cleveland Guardians face the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs Reds Game Info

• Cleveland Guardians (24-21) vs. Cincinnati Reds (23-21)
• Date: Friday, May 15, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Reds.TV

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | CIN: (+114)
• Spread: CLE: -1.5 (+162) | CIN: +1.5 (-196)
• Total: 8 -- Over: (-104) | Under: (-118)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-5, 4.17 ERA vs Andrew Abbott (Reds) - 2-2, 4.47 ERA

This contest's pitching matchup is set, as the Guardians will send Tanner Bibee (0-5) to the mound, while Andrew Abbott (2-2) will take the ball for the Reds. Bibee's team is 1-7-0 against the spread this season in his starts. Bibee and his team have lost each of the four games he's started as the moneyline favorite. The Reds have a 6-3-0 ATS record in Abbott's nine starts that had a set spread. The Reds have been the underdog on the moneyline in six of Abbott's starts this season, and they went 3-3 in those games.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.1%)

Guardians vs Reds Moneyline

• The Guardians vs Reds moneyline has Cleveland as a -134 favorite, while Cincinnati is a +114 underdog on the road.

Guardians vs Reds Spread

• The Reds are at the Guardians, and are +1.5 on the runline. The Reds are +162 to cover the spread, and the Guardians are -196.

Guardians vs Reds Over/Under

• The Guardians-Reds contest on May 15 has been given an over/under of 8 runs. The over is set at -104 and the under at -118.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have been chosen as favorites in 22 games this year and have walked away with the win 12 times (54.5%) in those games.
• Cleveland has a record of 6-4 when favored by -134 or more this year.
• The Guardians and their opponents have gone over the total this season in 22 of their 43 opportunities.
• The Guardians are 23-20-0 against the spread in their 43 games with a line set by sportsbooks this season.
• The Reds have won 56% of the games this season they were the moneyline underdog (14-11).
• Cincinnati has gone 5-6 when playing as a moneyline underdog with odds of +114 or longer (45.5%).
• The Reds have had an over/under set by bookmakers 42 times, and have combined with opponents to go over the total in 26 of those games (26-15-1).
• The Reds have a 25-17-0 record against the spread this season (covering 59.5% of the time).

Guardians Player Leaders

• Jose Ramirez is batting .207 with eight doubles, six home runs and 32 walks. He has an on-base percentage of .340 while slugging .366.
• Among all qualified batters in baseball, he is 146th in batting average, 72nd in on-base percentage, and 115th in slugging.
• Chase DeLauter has 42 hits and an OBP of .376 to go with a slugging percentage of .503. All three of those stats are tops among Cleveland hitters this season. He's batting .294.
• Among qualifying hitters, he is 25th in batting average, 27th in on-base percentage and 25th in slugging percentage.
• Brayan Rocchio has collected 39 base hits, an OBP of .350 and a slugging percentage of .373 this season.
• Angel Martinez is batting .260 with a .300 OBP and 19 RBI for Cleveland this season.
• Martinez takes a three-game hitting streak into this game. In his last five games he is hitting .200 with two home runs and three RBIs.

Reds Player Leaders

• Elly De La Cruz has a team-high OBP (.359) and slugging percentage (.525), and paces the Reds in hits (53, while batting .299).
• Including all the qualified players in the majors, his batting average ranks 20th, his on-base percentage ranks 47th, and he is 15th in slugging.
• De La Cruz hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is hitting .386 with four doubles, a walk and four RBIs.
• Sal Stewart is hitting .244 with eight doubles, 10 home runs and 22 walks. He's slugging .470 with an on-base percentage of .328.
• His batting average ranks 97th among all qualified players, his on-base percentage ranks 91st, and he is 48th in slugging.
• Spencer Steer has seven doubles, seven home runs and 14 walks while batting .259.
• Matt McLain has eight doubles, four home runs and 22 walks while hitting .208.

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