Guardians vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 25

Odds updated as of 6:14 p.m.

On Monday in MLB, the Cleveland Guardians are up against the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Guardians vs Rays Game Info

• Cleveland Guardians (64-65) vs. Tampa Bay Rays (63-67)
• Date: Monday, August 25, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Fox Sports 1, CLEG, and FDSSUN

Guardians vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-120) | TB: (+102)
• Spread: CLE: -1.5 (+172) | TB: +1.5 (-210)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Guardians vs Rays Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 9-9, 4.55 ERA vs Ian Seymour (Rays) - 1-0, 3.86 ERA

The Guardians will give the nod to Tanner Bibee (9-9, 4.55 ERA), who is eyeing win No. 10 on the season, and the Rays will counter with Ian Seymour (1-0, 3.86 ERA). When Bibee starts, his team is 15-9-0 against the spread this season. Bibee's team has been victorious in 69.2% of the games he's started as the moneyline favorite with a record of 9-4. Seymour never pitched as a moneyline underdog a season ago.

Guardians vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (55.2%)

Guardians vs Rays Moneyline

• Cleveland is the favorite, -120 on the moneyline, while Tampa Bay is a +102 underdog on the road.

Guardians vs Rays Spread

• The Guardians are hosting the Rays and are favored by 1.5 runs on the spread. The Guardians are +172 to cover the runline, with the Rays being -210.

Guardians vs Rays Over/Under

• An over/under of 7.5 has been set for Guardians-Rays on Aug. 25, with the over being -106 and the under -114.

Bet on Cleveland Guardians vs. Tampa Bay Rays on FanDuel today!

Guardians vs Rays Betting Trends

• The Guardians have been favorites in 53 games this season and have come away with the win 33 times (62.3%) in those contests.
• Cleveland has a record of 27-13 when favored by -120 or more this year.
• The Guardians' games have gone over the total in 57 of their 126 opportunities.
• In 126 games with a line this season, the Guardians have a mark of 65-61-0 against the spread.
• The Rays have been the underdog on the moneyline 62 total times this season. They've gone 24-38 in those games.
• Tampa Bay has a 19-23 record (winning 45.2% of its games) when playing as a moneyline underdog of +102 or longer.
• In the 125 games bookmakers have set an over/under for the Rays, they have combined with opponents to go over the total 53 times (53-66-6).
• The Rays have covered 42.4% of their games this season, going 53-72-0 against the spread.

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.362), slugging percentage (.512) and total hits (137) this season. He has a .288 batting average.
• Among qualifying hitters in baseball, his batting average ranks 20th, his on-base percentage ranks 25th, and he is 14th in slugging.
• Steven Kwan is batting .273 with 22 doubles, a triple, 10 home runs and 43 walks, while slugging .383 with an on-base percentage of .331.
• He is 41st in batting average, 75th in on-base percentage and 127th in slugging in MLB.
• Carlos Santana has 89 hits this season and has a slash line of .226/.319/.336.
• Santana has recorded a hit in three straight games. During his last five outings he is hitting .176 with a double, three walks and an RBI.
• Kyle Manzardo has 21 home runs, 55 RBI and a batting average of .233 this season.
• Manzardo has safely hit in three games in a row. In his last five games he is batting .176 with .

Rays Player Leaders

• Junior Caminero is leading the Rays with 124 hits. He's batting .255 and slugging .527 with an on-base percentage of .298.
• Including all qualified hitters, he is 88th in batting average, while his on-base percentage ranks 135th and he is 11th in slugging.
• Caminero hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .200 with two home runs, three walks and six RBIs.
• Yandy Diaz leads his team with a .459 slugging percentage. He has a batting average of .279 with an on-base percentage of .338.
• He is currently 31st in batting average, 60th in on-base percentage and 55th in slugging percentage among all qualifying hitters.
• Brandon Lowe is batting .266 with 13 doubles, 25 home runs and 31 walks.
• Chandler Simpson has 11 doubles, three triples and 18 walks while hitting .307.

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