Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for July 23

Odds updated as of 11:12 a.m.

On Wednesday in MLB, the Cleveland Guardians are playing the Baltimore Orioles.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Guardians vs Orioles Game Info

• Cleveland Guardians (50-50) vs. Baltimore Orioles (44-56)
• Date: Wednesday, July 23, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MASN2

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-124) | BAL: (+106)
• Spread: CLE: -1.5 (+164) | BAL: +1.5 (-200)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 5-4, 3.84 ERA vs Zach Eflin (Orioles) - 6-5, 5.95 ERA

The Guardians will give the ball to Slade Cecconi (5-4, 3.84 ERA), who is eyeing win No. 6 on the season, and the Orioles will counter with Zach Eflin (6-5, 5.95 ERA). Cecconi's team is 8-3-0 against the spread in his starts this season. Cecconi's team is 3-2 this season when he starts and they are the moneyline favorite. When Eflin starts, the Orioles have gone 5-7-0 against the spread. The Orioles have been the moneyline underdog in six of Eflin's starts this season, and they went 3-3 in those matchups.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.1%)

Guardians vs Orioles Moneyline

• Baltimore is a +106 underdog on the moneyline, while Cleveland is a -124 favorite at home.

Guardians vs Orioles Spread

• The Guardians are hosting the Orioles and are favored by 1.5 runs on the spread. The Guardians are +164 to cover the runline, with the Orioles being -200.

Guardians vs Orioles Over/Under

• An over/under of 8.5 has been set for Guardians-Orioles on July 23, with the over being -114 and the under -106.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have been victorious in 24, or 63.2%, of the 38 contests they have been chosen as favorites in this season.
• This year Cleveland has won 16 of 24 games when listed as at least -124 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 45 of their 98 opportunities.
• The Guardians have an against the spread record of 51-47-0 in 98 games with a line this season.
• The Orioles have won 44% of the games this season they were the moneyline underdog (22-28).
• In games it has played as a moneyline underdog with odds of +106 or longer, Baltimore has a 13-17 record (winning 43.3% of its games).
• The Orioles have combined with opponents to hit the over on the total 43 times this season for a 43-52-3 record against the over/under.
• The Orioles have put together a 40-58-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.370), slugging percentage (.529) and total hits (107) this season. He has a .295 batting average.
• Among all qualified batters in baseball, he is ninth in batting average, 21st in on-base percentage, and 14th in slugging.
• Ramirez will look for his third straight game with a hit in this contest. In his last five games he is hitting .294 with a double, a triple, three home runs, six walks and six RBIs.
• Steven Kwan has 20 doubles, a triple, six home runs and 36 walks. He's batting .285 and slugging .393 with an on-base percentage of .348.
• Among qualifiers, he is 25th in batting average, 48th in on-base percentage and 111th in slugging percentage.
• Carlos Santana has collected 75 base hits, an OBP of .323 and a slugging percentage of .350 this season.
• Angel Martinez is batting .254 with a .278 OBP and 38 RBI for Cleveland this season.
• Martinez has hit safely in five straight games. In his last five games he is hitting .458 with four doubles, a home run and four RBIs.

Orioles Player Leaders

• Gunnar Henderson has racked up a slugging percentage of .456 and has 98 hits, both team-high numbers for the Orioles. He's batting .278 and with an on-base percentage of .345.
• Including all the qualified hitters in MLB, his batting average is 39th, his on-base percentage is 54th, and he is 54th in slugging.
• Ryan O'Hearn has a .375 on-base percentage to lead his team. He has a batting average of .280 while slugging .453.
• Including all qualifying players, his batting average puts him 33rd, his on-base percentage is 15th, and he is 56th in slugging.
• Jackson Holliday is hitting .260 with 14 doubles, two triples, 13 home runs and 22 walks.
• Cedric Mullins is hitting .213 with 14 doubles, 13 home runs and 32 walks.

Guardians vs Orioles Head to Head

• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 8-4 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!