Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 6:12 p.m.

The Cleveland Guardians versus the Baltimore Orioles is on the MLB schedule for Tuesday.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Orioles Game Info

• Cleveland Guardians (49-50) vs. Baltimore Orioles (44-55)
• Date: Tuesday, July 22, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MASN2

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-162) | BAL: (+136)
• Spread: CLE: -1.5 (+132) | BAL: +1.5 (-160)
• Total: 8 -- Over: (-114) | Under: (-106)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 1-0, 4.17 ERA vs Brandon Young (Orioles) - 0-4, 7.52 ERA

The Guardians will call on Joey Cantillo (1-0) versus the Orioles and Brandon Young (0-4). Cantillo's team is 2-1-0 against the spread in his starts this season. Cantillo's team won his only start as a favorite this season. When Young starts, the Orioles are 3-2-0 against the spread. The Orioles were named the moneyline underdog for four Young starts this season -- they lost every time.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59.3%)

Guardians vs Orioles Moneyline

• Cleveland is a -162 favorite on the moneyline, while Baltimore is a +136 underdog on the road.

Guardians vs Orioles Spread

• The Orioles are +1.5 on the run line against the Guardians. The Orioles are -160 to cover, and the Guardians are +132.

Guardians vs Orioles Over/Under

• An over/under of 8 has been set for Guardians-Orioles on July 22, with the over being -114 and the under -106.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have come away with 23 wins in the 37 contests they have been listed as the favorites in this season.
• Cleveland has been a -162 moneyline favorite on five occasions this season and won every time.
• The Guardians and their opponents have gone over in 44 of their 97 games with a total set by sportsbooks this season.
• The Guardians are 50-47-0 against the spread in their 97 games with a line set by sportsbooks this season.
• The Orioles have won 44.9% of the games this season they were the underdog on the moneyline (22-27).
• Baltimore has a 2-7 record (winning only 22.2% of its games) when playing as a moneyline underdog of +136 or longer.
• The Orioles have had an over/under set by oddsmakers 97 times, and have combined with opponents to go over the total in 42 of those games (42-52-3).
• The Orioles have a 40-57-0 record ATS this season (covering 41.2% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 106 hits and an OBP of .364, plus a team-best slugging percentage of .521. He's batting .294.
• He ranks 10th in batting average, 27th in on-base percentage, and 15th in slugging among all qualifying hitters in baseball.
• Steven Kwan has 20 doubles, a triple, six home runs and 36 walks. He's batting .288 and slugging .398 with an on-base percentage of .352.
• His batting average ranks 20th among qualified players, his on-base percentage 45th, and his slugging percentage 104th.
• Carlos Santana is batting .231 with a .354 slugging percentage and 43 RBI this year.
• Santana has recorded a hit in two games in a row. In his last five games he is hitting .167 with two walks and two RBIs.
• Kyle Manzardo is batting .219 with a .295 OBP and 38 RBI for Cleveland this season.

Orioles Player Leaders

• Gunnar Henderson has a team-best slugging percentage (.459) and paces the Orioles in hits (98). He's batting .279 and with an on-base percentage of .344.
• Including all qualified players, he ranks 33rd in batting average, while his on-base percentage ranks 57th and he is 50th in slugging.
• Ryan O'Hearn has a .373 on-base percentage to pace his team. He has a batting average of .278 while slugging .451.
• Including all qualified players, his batting average puts him 38th, his on-base percentage ranks 16th, and he is 60th in slugging.
• Jackson Holliday has 14 doubles, two triples, 13 home runs and 21 walks while batting .260.
• Cedric Mullins is batting .216 with 14 doubles, 13 home runs and 32 walks.

Guardians vs Orioles Head to Head

• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 8-4 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/25/2024: 10-8 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!