Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 8:11 a.m.

In MLB action on Tuesday, the Cleveland Guardians play the Baltimore Orioles.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Orioles Game Info

• Cleveland Guardians (49-50) vs. Baltimore Orioles (44-55)
• Date: Tuesday, July 22, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MASN2

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-138) | BAL: (+118)
• Spread: CLE: -1.5 (+146) | BAL: +1.5 (-178)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 1-0, 4.17 ERA vs Brandon Young (Orioles) - 0-4, 7.52 ERA

The Guardians will give the ball to Joey Cantillo (1-0, 4.17 ERA), who is eyeing win No. 2 on the season, and the Orioles will turn to Brandon Young (0-4, 7.52 ERA). Cantillo's team is 2-1-0 against the spread in his starts this season. Cantillo's team won his only start as a favorite this season. The Orioles have a 3-2-0 ATS record in Young's five starts that had a set spread. The Orioles were the underdog on the moneyline for four Young starts this season -- they lost each time.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59.3%)

Guardians vs Orioles Moneyline

• Looking at the moneyline for Guardians-Orioles, Cleveland is the favorite at -138, and Baltimore is +118 playing on the road.

Guardians vs Orioles Spread

• The Orioles are +1.5 on the run line against the Guardians. The Orioles are -178 to cover, and the Guardians are +146.

Guardians vs Orioles Over/Under

• Guardians versus Orioles on July 22 has an over/under of 8.5 runs, with the odds on the over -105 and the under set at -115.

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Guardians vs Orioles Betting Trends

• The Guardians have come away with 23 wins in the 37 contests they have been listed as the favorites in this season.
• Cleveland has a record of 7-3 when favored by -138 or more this year.
• The Guardians and their opponents have gone over in 44 of their 97 games with a total set by sportsbooks this season.
• The Guardians are 50-47-0 against the spread in their 97 games with a line set by sportsbooks this season.
• The Orioles have gone 22-27 in games they were the underdog on the moneyline (winning 44.9% of those games).
• Baltimore has an 8-11 record (winning 42.1% of its games) when playing as a moneyline underdog of +118 or longer.
• In the 97 games oddsmakers have set an over/under for the Orioles, they have combined with opponents to go over the total 42 times (42-52-3).
• The Orioles have a 40-57-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 106 hits and an OBP of .364, plus a team-best slugging percentage of .521. He's batting .294.
• Among qualified hitters in the majors, his batting average ranks 10th, his on-base percentage ranks 27th, and he is 15th in slugging.
• Steven Kwan has 20 doubles, a triple, six home runs and 36 walks. He's batting .288 and slugging .398 with an on-base percentage of .352.
• He ranks 20th in batting average, 45th in on-base percentage and 104th in slugging among qualified hitters.
• Carlos Santana is batting .231 with a .354 slugging percentage and 43 RBI this year.
• Santana heads into this game with two games in a row with at least one hit. In his last five games he is batting .167 with two walks and two RBIs.
• Kyle Manzardo is batting .219 with a .295 OBP and 38 RBI for Cleveland this season.

Orioles Player Leaders

• Gunnar Henderson has put up a team-high slugging percentage (.459) while leading the Orioles in hits (98). He's batting .279 and with an on-base percentage of .344.
• Including all the qualifying hitters in the majors, his batting average ranks 33rd, his on-base percentage is 57th, and he is 50th in slugging.
• Ryan O'Hearn's .373 OBP leads his team. He has a batting average of .278 while slugging .451.
• He is 38th in batting average, 16th in on-base percentage and 60th in slugging percentage in MLB.
• Jackson Holliday is hitting .260 with 14 doubles, two triples, 13 home runs and 21 walks.
• Cedric Mullins has 14 doubles, 13 home runs and 32 walks while hitting .216.

Guardians vs Orioles Head to Head

• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 8-4 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/25/2024: 10-8 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)

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