Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 7

Odds updated as of 11:11 a.m.

The Wednesday slate in MLB includes a matchup between the Cleveland Guardians and the Washington Nationals.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Nationals Game Info

• Cleveland Guardians (21-15) vs. Washington Nationals (17-20)
• Date: Wednesday, May 7, 2025
• Time: 12:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CLEG

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | WSH: (-100)
• Spread: CLE: -1.5 (+130) | WSH: +1.5 (-156)
• Total: 9 -- Over: (-122) | Under: (-100)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Logan Allen (Guardians) - 1-2, 4.02 ERA vs Michael Soroka (Nationals) - 0-1, 7.20 ERA

The Guardians will give the nod to Logan Allen (1-2, 4.02 ERA), who is eyeing win No. 2 on the season, and the Nationals will turn to Michael Soroka (0-1, 7.20 ERA). Allen's team is 1-5-0 against the spread this season in his starts. Allen's team won his only start as a favorite this season. Soroka has started just one game with a set spread, which the Nationals failed to cover. The Nationals were named the moneyline underdog for one Soroka start this season -- they lost.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.6%)

Guardians vs Nationals Moneyline

• Looking at the moneyline for Guardians-Nationals, Cleveland is the favorite at -118, and Washington is -100 playing at home.

Guardians vs Nationals Spread

• The Nationals are +1.5 on the run line against the Guardians. The Nationals are -156 to cover, and the Guardians are +130.

Guardians vs Nationals Over/Under

• The over/under for Guardians-Nationals on May 7 is 9. The over is -122, and the under is -100.

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Guardians vs Nationals Betting Trends

• The Guardians have come away with nine wins in the 13 contests they have been listed as the favorites in this season.
• This season Cleveland has come away with a win six times in nine chances when named as a favorite of at least -118 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 20 of their 35 opportunities.
• The Guardians have an against the spread record of 16-19-0 in 35 games with a line this season.
• The Nationals have won 51.9% of the games this season they were the moneyline underdog (14-13).
• Washington has a record of 12-12 when playing as a moneyline underdog with odds of -100 or longer (50%).
• The Nationals have played in 35 games with a set over/under, and have combined with their opponents to go over the total 19 times (19-16-0).
• The Nationals have put together a 20-15-0 record ATS this season.

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.850) this season. He has a .333 batting average, an on-base percentage of .385, and a slugging percentage of .465.
• Among qualifying batters in MLB, his batting average ranks fifth, his on-base percentage ranks 21st, and he is 45th in slugging.
• Kwan has picked up at least one hit in five straight games. In his last five games he is batting .455 with two doubles, two walks and two RBIs.
• Jose Ramirez is batting .272 with seven doubles, five home runs and 12 walks, while slugging .448 with an on-base percentage of .331.
• Among qualifying hitters, his batting average ranks him 50th, his on-base percentage 71st, and his slugging percentage 55th.
• Ramirez has picked up a hit in two games in a row. In his last five games he is batting .316 with two doubles, three walks and two RBIs.
• Kyle Manzardo leads Cleveland in total hits (23) this season, and 12 of those have gone for extra bases.
• Carlos Santana has four home runs, 13 RBI and a batting average of .236 this season.
• Santana takes a two-game hitting streak into this matchup. In his last five games he is hitting .333 with two home runs, five walks and six RBIs.

Nationals Player Leaders

• James Wood has accumulated a team-best OBP (.378) and slugging percentage (.550), and leads the Nationals in hits (38, while batting .271).
• Including all qualified players in the majors, he is 51st in batting average, 29th in on-base percentage and 15th in slugging percentage.
• Wood enters this game on a six-game hitting streak. During his last 10 games he is batting .308 with four doubles, two home runs, eight walks and four RBIs.
• Nathaniel Lowe is batting .259 with seven doubles, six home runs and 14 walks. He's slugging .439 with an on-base percentage of .331.
• He is currently 64th in batting average, 71st in on-base percentage and 57th in slugging percentage among all qualifying batters.
• C.J. Abrams is batting .272 with five doubles, two triples, four home runs and eight walks.
• Keibert Ruiz is hitting .305 with five doubles, two home runs and seven walks.

Guardians vs Nationals Head to Head

• 5/6/2025: 9-1 CLE (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/6/2025: 10-9 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/2/2024: 5-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/16/2023: 7-6 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 4/14/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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