Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 2:11 a.m.

Monday's slate in the MLB includes a matchup between the Cleveland Guardians and the Washington Nationals.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Nationals Game Info

• Cleveland Guardians (20-14) vs. Washington Nationals (16-19)
• Date: Monday, May 5, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and CLEG

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | WSH: (-100)
• Spread: CLE: -1.5 (+128) | WSH: +1.5 (-154)
• Total: 9 -- Over: (-102) | Under: (-120)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 2-3, 4.78 ERA vs Jake Irvin (Nationals) - 2-1, 4.01 ERA

This contest's pitching matchup is set, as the Guardians will send Luis Ortiz (2-3) to the mound, while Jake Irvin (2-1) will get the nod for the Nationals. When Ortiz starts, his team is 3-3-0 against the spread this season. Ortiz's team is 2-1 this season when he starts and they are the moneyline favorite. The Nationals are 3-4-0 ATS in Irvin's seven starts that had a set spread. The Nationals are 3-4 in Irvin's seven starts this season that they were the moneyline underdog.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.9%)

Guardians vs Nationals Moneyline

• The moneyline numbers for Guardians vs. Nationals reveal Cleveland as the favorite (-118) and Washington as the underdog (-100) despite being the home team.

Guardians vs Nationals Spread

• The Guardians are 1.5-run road favorites on the runline against the Nationals. The Guardians are +128 to cover, and the Nationals are -154.

Guardians vs Nationals Over/Under

• A combined run total of 9 has been set for Guardians-Nationals on May 5, with the over at -102 and the under at -120.

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Guardians vs Nationals Betting Trends

• The Guardians have come away with nine wins in the 12 contests they have been listed as the favorites in this season.
• Cleveland has a record of 6-2 in contests when sportsbooks favor them by -118 or more on the moneyline.
• The Guardians and their opponents have hit the over in 18 of their 33 games with a total set by oddsmakers this season.
• The Guardians are 15-18-0 against the spread in their 33 games with a line set by sportsbooks this season.
• The Nationals are 13-13 in games they were listed as the moneyline underdog (winning 50% of those games).
• Washington has a 12-12 record (winning 50% of its games) when playing as a moneyline underdog of -100 or longer.
• The Nationals have had an over/under set by oddsmakers 33 times, and have combined with opponents to go over the total in 17 of those games (17-16-0).
• The Nationals are 19-14-0 against the spread this season.

Guardians Player Leaders

• Steven Kwan has an OPS of .850, fueled by an OBP of .384 to go with a slugging percentage of .467. He has a .333 batting average, as well.
• Among the qualifying hitters in MLB, his batting average ranks fifth, his on-base percentage ranks 20th, and he is 45th in slugging.
• Kwan has picked up at least one hit in three straight games. During his last five outings he is batting .333 with a double, two walks and an RBI.
• Jose Ramirez is hitting .265 with five doubles, five home runs and 10 walks. He's slugging .436 with an on-base percentage of .318.
• Among qualified hitters, he is 59th in batting average, 88th in on-base percentage and 59th in slugging percentage.
• Kyle Manzardo leads Cleveland with 23 hits. He is batting .219 this season and 12 of his hits have gone for extra bases.
• Carlos Santana is batting .219 with a .316 OBP and 10 RBI for Cleveland this season.

Nationals Player Leaders

• James Wood has 36 hits with a .381 on-base percentage and a .545 slugging percentage, all club-bests for the Nationals. He's batting .273.
• Including all the qualified hitters in the majors, his batting average ranks 49th, his on-base percentage is 21st, and he is 17th in slugging.
• Wood hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .368 with two doubles and four walks.
• Nathaniel Lowe is batting .254 with seven doubles, six home runs and 14 walks. He's slugging .446 with an on-base percentage of .331.
• Including all qualifying hitters, his batting average puts him 75th, his on-base percentage ranks 69th, and he is 53rd in slugging.
• Luis Garcia has five doubles, three home runs and eight walks while hitting .234.
• C.J. Abrams has five doubles, two triples, four home runs and four walks while batting .284.

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