Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 6:11 p.m.

The MLB schedule on Tuesday includes the Cleveland Guardians taking on the Washington Nationals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Nationals Game Info

• Cleveland Guardians (20-14) vs. Washington Nationals (16-19)
• Date: Tuesday, May 6, 2025
• Time: 6:35 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and CLEG

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | WSH: (-100)
• Spread: CLE: -1.5 (+146) | WSH: +1.5 (-176)
• Total: 9 -- Over: (-122) | Under: (-100)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Edward Lively (Guardians) - 1-2, 3.72 ERA vs Brad Lord (Nationals) - 1-3, 4.43 ERA

This contest's pitching matchup is set, as the Guardians will send Edward Lively (1-2) to the mound, while Brad Lord (1-3) will answer the bell for the Nationals. Lively's team is 4-3-0 against the spread this season in his starts. Lively's team won his only start as a favorite this season. The Nationals have a 2-2-0 ATS record in Lord's four starts that had a set spread. The Nationals are 2-1 in Lord's three starts this season that they were the underdog on the moneyline.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.6%)

Guardians vs Nationals Moneyline

• Washington is a -100 underdog on the moneyline, while Cleveland is a -118 favorite on the road.

Guardians vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Guardians. The Nationals are -176 to cover the spread, and the Guardians are +146.

Guardians vs Nationals Over/Under

• A combined run total of 9 has been set for Guardians-Nationals on May 6, with the over at -122 and the under at -100.

Bet on Cleveland Guardians vs. Washington Nationals on FanDuel today!

Guardians vs Nationals Betting Trends

• The Guardians have won in nine, or 75%, of the 12 contests they have been named as odds-on favorites in this year.
• This season Cleveland has been victorious six times in eight chances when named as a favorite of at least -118 on the moneyline.
• The Guardians' games have gone over the total in 18 of their 33 opportunities.
• The Guardians are 15-18-0 against the spread in their 33 games with a line set by sportsbooks this season.
• The Nationals have put together a 13-13 record in games they were listed as the moneyline underdog (winning 50% of those games).
• Washington has a 12-12 record (winning 50% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Nationals have played in 33 games with a set over/under, and have combined with their opponents to go over the total 17 times (17-16-0).
• The Nationals have covered 57.6% of their games this season, going 19-14-0 against the spread.

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.850) this season. He has a .333 batting average, an on-base percentage of .384, and a slugging percentage of .467.
• Among all qualified hitters, he ranks sixth in batting average, his on-base percentage ranks 24th, and he is 45th in slugging.
• Kwan hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .333 with a double, two walks and an RBI.
• Jose Ramirez is hitting .265 with five doubles, five home runs and 10 walks, while slugging .436 with an on-base percentage of .318.
• Among qualified hitters, he is 58th in batting average, 87th in on-base percentage and 60th in slugging percentage.
• Kyle Manzardo leads Cleveland with 23 hits. He is batting .219 this season and 12 of his hits have gone for extra bases.
• Carlos Santana is batting .219 with a .316 OBP and 10 RBI for Cleveland this season.

Nationals Player Leaders

• James Wood has racked up a team-high OBP (.381) and slugging percentage (.545), and paces the Nationals in hits (36, while batting .273).
• Including all qualifying hitters in MLB, he is 50th in batting average, 26th in on-base percentage and 17th in slugging percentage.
• Wood hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .368 with two doubles and four walks.
• Nathaniel Lowe has seven doubles, six home runs and 14 walks while hitting .254. He's slugging .446 with an on-base percentage of .331.
• He ranks 75th in batting average, 71st in on-base percentage and 54th in slugging percentage in the majors.
• Luis Garcia is batting .234 with five doubles, three home runs and eight walks.
• Keibert Ruiz has four doubles, two home runs and seven walks while batting .298.

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