Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 1:12 p.m.

In MLB action on Wednesday, the Cleveland Guardians play the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Guardians vs Nationals Game Info

• Cleveland Guardians (32-25) vs. Washington Nationals (29-27)
• Date: Wednesday, May 27, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Nationals.TV

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-184) | WSH: (+154)
• Spread: CLE: -1.5 (+114) | WSH: +1.5 (-137)
• Total: 8 -- Over: (-102) | Under: (-120)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 7-3, 3.25 ERA vs PJ Poulin (Nationals) - 3-0, 3.42 ERA

The probable starters are Gavin Williams (7-3) for the Guardians and PJ Poulin (3-0) for the Nationals. Williams and his team have a record of 7-3-0 against the spread when he starts. Williams' team has been victorious in 71.4% of the games he's started as the moneyline favorite with a record of 5-2. The Nationals have gone 5-1-0 against the spread when Poulin starts. The Nationals have a 4-2 record in Poulin's six starts this season when they were the underdog on the moneyline.

Guardians vs Nationals Moneyline

• The moneyline numbers for Guardians vs. Nationals reveal Cleveland as the favorite (-184) and Washington as the underdog (+154) on the road.

Guardians vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Guardians. The Nationals are -137 to cover the spread, and the Guardians are +114.

Guardians vs Nationals Over/Under

• The over/under for the Guardians versus Nationals contest on May 27 has been set at 8, with -102 odds on the over and -120 odds on the under.

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Guardians vs Nationals Betting Trends

• The Guardians have won in 17, or 56.7%, of the 30 contests they have been named as odds-on favorites in this year.
• These are the best odds of a victory sportsbooks have given Cleveland this season, with a -184 moneyline set for this game.
• Contests with the Guardians have gone over the total set by sportsbooks in 27 of 53 chances this season.
• The Guardians have posted a record of 28-25-0 against the spread this season.
• The Nationals have won 27 of the 53 games they were the underdog on the moneyline this season (50.9%).
• Washington has gone 5-8 in games it has played as a moneyline underdog with odds of +154 or longer (38.5%).
• The Nationals have had an over/under set by bookmakers 56 times, and have combined with opponents to go over the total in 35 of those games (35-18-3).
• The Nationals have collected a 35-21-0 record ATS this season (covering 62.5% of the time).

Guardians Player Leaders

• Jose Ramirez is hitting .229 with 12 doubles, eight home runs and 37 walks. He has an on-base percentage of .344 and a slugging percentage of .400.
• Among all qualifying hitters in MLB, he is 117th in batting average, 63rd in on-base percentage, and 85th in slugging.
• Ramirez has recorded a base hit in two straight games. During his last five outings he is batting .158 with a double and two RBIs.
• Chase DeLauter is batting .255 with 11 doubles, a triple, seven home runs and 25 walks. He's slugging .436 with an on-base percentage of .340.
• Among qualifying hitters, his batting average ranks him 79th, his on-base percentage 69th, and his slugging percentage 62nd.
• Brayan Rocchio leads the Guardians with an OPS of .801. He has a slash line of .299/.382/.420 this season.
• Rocchio heads into this matchup with two games in a row with at least one hit. In his last five games he is hitting .533 with two doubles.
• Angel Martinez leads Cleveland with 42 hits, batting .240 this season with 19 extra-base hits.

Nationals Player Leaders

• James Wood has accumulated 59 hits with a .413 on-base percentage and a .551 slugging percentage, all club-highs for the Nationals. He's batting .276.
• Including all qualified hitters in the big leagues, he is 44th in batting average, third in on-base percentage and 10th in slugging percentage.
• C.J. Abrams is batting .289 with 11 doubles, two triples, 12 home runs and 25 walks. He's slugging .542 with an on-base percentage of .381.
• He is 27th in batting average, 22nd in on-base percentage and 15th in slugging percentage in the big leagues.
• Daylen Lile is hitting .262 with 15 doubles, a triple, seven home runs and 19 walks.
• Curtis Mead is batting .235 with eight doubles, seven home runs and 20 walks.

Guardians vs Nationals Head to Head

• 5/26/2026: 6-3 WSH (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/25/2026: 10-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/7/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/6/2025: 9-1 CLE (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/6/2025: 10-9 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/2/2024: 5-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/16/2023: 7-6 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 4/14/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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