Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 1:12 p.m.

MLB action on Wednesday includes the Milwaukee Brewers taking on the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (32-20) vs. St. Louis Cardinals (29-24)
• Date: Wednesday, May 27, 2026
• Time: 1:40 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-168) | STL: (+142)
• Spread: MIL: -1.5 (+122) | STL: +1.5 (-146)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 2-2, 2.63 ERA vs Dustin May (Cardinals) - 3-5, 5.00 ERA

The Brewers will give the nod to Chad Patrick (2-2) against the Cardinals and Dustin May (3-5). Patrick's team is 4-1-0 against the spread this season in his starts. Patrick's team is 3-1 this season when he starts and they are the moneyline favorite. When May starts, the Cardinals are 5-5-0 against the spread. The Cardinals are 3-5 in May's eight starts this season that they were the underdog on the moneyline.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (56.3%)

Brewers vs Cardinals Moneyline

• Milwaukee is a -168 favorite on the moneyline, while St. Louis is a +142 underdog on the road.

Brewers vs Cardinals Spread

• The Cardinals are at the Brewers, and are +1.5 on the runline. The Cardinals are +122 to cover the spread, and the Brewers are -146.

Brewers vs Cardinals Over/Under

• Brewers versus Cardinals, on May 27, has an over/under of 8.5, with the over being +100 and the under -122.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been favorites in 31 games this season and have come away with the win 20 times (64.5%) in those contests.
• This season Milwaukee has been victorious four times in seven chances when named as a favorite of at least -168 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 22 of their 52 opportunities.
• The Brewers are 32-20-0 against the spread in their 52 games with a line set by sportsbooks this season.
• The Cardinals have been the underdog on the moneyline 43 total times this season. They've gone 24-19 in those games.
• St. Louis is 3-3 (winning 50% of its games) when it has played as a moneyline underdog of +142 or longer.
• The Cardinals have combined with opponents to go over the total 22 times this season for a 22-26-4 record against the over/under.
• The Cardinals have covered 57.7% of their games this season, going 30-22-0 against the spread.

Brewers Player Leaders

• Brice Turang has 51 hits this season and a team-best OBP of .407. He has a .282 batting average and a slugging percentage of .470.
• Among qualified hitters, he is 39th in batting average, his on-base percentage ranks fourth, and he is 40th in slugging.
• William Contreras leads Milwaukee in slugging percentage (.410) thanks to 13 extra-base hits. He's batting .303 with an on-base percentage of .372.
• Among all qualified batters, he ranks 10th in batting average, 28th in on-base percentage and 82nd in slugging percentage.
• Contreras brings a 10-game streak with at least one hit into this one. During his last 10 outings he is batting .405 with a double, a home run, two walks and seven RBIs.
• Jake Bauers has 47 hits and is batting .290 this season.
• Bauers enters this game with two games in a row with at least one hit. In his last five games he is hitting .278 with a home run and two RBIs.
• Sal Frelick has been key for Milwaukee with 36 hits, an OBP of .292 plus a slugging percentage of .305.

Cardinals Player Leaders

• Jordan Walker has put up a team-high slugging percentage (.578) while leading the Cardinals in hits (59). He's batting .296 and with an on-base percentage of .365.
• Including all qualified players in MLB, his batting average puts him 22nd, his on-base percentage ranks 34th, and he is fourth in slugging.
• Alec Burleson is hitting .287 with 13 doubles, seven home runs and 21 walks. He's slugging .455 with an on-base percentage of .357.
• Including all qualifying players, he ranks 31st in batting average, 45th in on-base percentage and 52nd in slugging percentage.
• Ivan Herrera has accumulated a team-high .388 on-base percentage.
• JJ Wetherholt is batting .234 with five doubles, nine home runs and 28 walks.

Brewers vs Cardinals Head to Head

• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/21/2025: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/20/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)

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