Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 6:12 p.m.

On Tuesday in MLB, the Cleveland Guardians are playing the Washington Nationals.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Nationals Game Info

• Cleveland Guardians (32-24) vs. Washington Nationals (28-27)
• Date: Tuesday, May 26, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Nationals.TV

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | WSH: (+110)
• Spread: CLE: -1.5 (+168) | WSH: +1.5 (-205)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 4-1, 3.05 ERA vs Cade Cavalli (Nationals) - 2-3, 3.86 ERA

The Guardians will give the nod to Joey Cantillo (4-1) versus the Nationals and Cade Cavalli (2-3). Cantillo's team is 9-2-0 against the spread in his starts this season. Cantillo's team is 4-1 this season when he starts and they are the moneyline favorite. The Nationals have gone 7-4-0 ATS in Cavalli's 11 starts with a set spread. The Nationals have a 2-7 record in Cavalli's nine starts this season when they were the moneyline underdog.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (62%)

Guardians vs Nationals Moneyline

• The moneyline numbers for Guardians vs. Nationals reveal Cleveland as the favorite (-130) and Washington as the underdog (+110) on the road.

Guardians vs Nationals Spread

• The Guardians are hosting the Nationals and are favored by 1.5 runs on the spread. The Guardians are +168 to cover the runline, with the Nationals being -205.

Guardians vs Nationals Over/Under

• Guardians versus Nationals, on May 26, has an over/under of 7.5, with the over being -106 and the under -114.

Bet on Cleveland Guardians vs. Washington Nationals on FanDuel today!

Guardians vs Nationals Betting Trends

• The Guardians have been chosen as favorites in 29 games this year and have walked away with the win 17 times (58.6%) in those games.
• Cleveland has a record of 10-8 in contests when oddsmakers favor them by -130 or more on the moneyline.
• The Guardians and their opponents have hit the over in 26 of their 52 games with a total set by oddsmakers this season.
• The Guardians have posted a record of 28-24-0 against the spread this season.
• The Nationals have a 26-26 record in games they were the underdog on the moneyline (winning 50% of those games).
• Washington has a 22-18 record (winning 55% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Nationals have had an over/under set by bookmakers 55 times, and have combined with opponents to go over the total in 34 of those games (34-18-3).
• The Nationals have a 34-21-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez has 11 doubles, eight home runs and 37 walks while hitting .228. He has an on-base percentage of .347 and a slugging percentage of .398.
• Among qualifying hitters, he is 120th in batting average, his on-base percentage ranks 60th, and he is 90th in slugging.
• Chase DeLauter is hitting .257 with 11 doubles, a triple, seven home runs and 25 walks. He's slugging .443 with an on-base percentage of .343.
• He is 75th in batting average, 64th in on-base percentage and 54th in slugging in MLB.
• Brayan Rocchio leads the Guardians with an OPS of .779. He has a slash line of .287/.369/.409 this season.
• Angel Martinez leads Cleveland with 42 hits, batting .246 this season with 19 extra-base hits.

Nationals Player Leaders

• C.J. Abrams has accumulated a slugging percentage of .545 and has 57 hits, both team-best numbers for the Nationals. He's batting .288 and with an on-base percentage of .379.
• He ranks 27th in batting average, 20th in on-base percentage and 11th in slugging percentage among all qualified hitters in MLB.
• James Wood paces his team with a .405 on-base percentage. He has a batting average of .267 while slugging .533.
• He is 56th in batting average, fourth in on-base percentage and 16th in slugging percentage in the big leagues.
• Daylen Lile has a team-high .436 slugging percentage.
• Curtis Mead is batting .241 with eight doubles, seven home runs and 18 walks.

Guardians vs Nationals Head to Head

• 5/25/2026: 10-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/7/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/6/2025: 9-1 CLE (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/6/2025: 10-9 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/2/2024: 5-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/16/2023: 7-6 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 4/14/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!