Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 12:12 a.m.

The Cleveland Guardians versus the Washington Nationals is on the MLB schedule for Tuesday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Nationals Game Info

• Cleveland Guardians (32-24) vs. Washington Nationals (28-27)
• Date: Tuesday, May 26, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Nationals.TV

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-138) | WSH: (+118)
• Spread: CLE: -1.5 (+162) | WSH: +1.5 (-196)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 4-1, 3.05 ERA vs Cade Cavalli (Nationals) - 2-3, 3.86 ERA

The Guardians will give the nod to Joey Cantillo (4-1, 3.05 ERA), who is eyeing win No. 5 on the season, and the Nationals will counter with Cade Cavalli (2-3, 3.86 ERA). Cantillo's team is 9-2-0 against the spread this season in his starts. Cantillo's team is 4-1 this season when he starts and they are the moneyline favorite. The Nationals have gone 7-4-0 ATS in Cavalli's 11 starts with a set spread. The Nationals are 2-7 in Cavalli's nine starts this season that they were the underdog on the moneyline.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59.5%)

Guardians vs Nationals Moneyline

• The moneyline numbers for Guardians vs. Nationals reveal Cleveland as the favorite (-138) and Washington as the underdog (+118) on the road.

Guardians vs Nationals Spread

• The Guardians are 1.5-run home favorites on the runline against the Nationals. The Guardians are +162 to cover, and the Nationals are -196.

Guardians vs Nationals Over/Under

• The over/under for the Guardians versus Nationals game on May 26 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

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Guardians vs Nationals Betting Trends

• The Guardians have come away with 17 wins in the 29 contests they have been listed as the favorites in this season.
• This season Cleveland has come away with a win eight times in 12 chances when named as a favorite of at least -138 on the moneyline.
• The Guardians' games have gone over the total in 26 of their 52 opportunities.
• The Guardians are 28-24-0 against the spread in their 52 games with a line set by sportsbooks this season.
• The Nationals have won 26 of the 52 games they were the moneyline underdog this season (50%).
• Washington has a 20-16 record (winning 55.6% of its games) when it has played as a moneyline underdog of +118 or longer.
• In the 55 games oddsmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 34 times (34-18-3).
• The Nationals have a 34-21-0 record against the spread this season (covering 61.8% of the time).

Guardians Player Leaders

• Jose Ramirez is batting .228 with 11 doubles, eight home runs and 37 walks. He has an on-base percentage of .347 while slugging .398.
• Among qualified hitters in the majors, his batting average ranks 120th, his on-base percentage ranks 60th, and he is 90th in slugging.
• Chase DeLauter has 11 doubles, a triple, seven home runs and 25 walks. He's batting .257 and slugging .443 with an on-base percentage of .343.
• He ranks 74th in batting average, 64th in on-base percentage and 56th in slugging among qualified hitters.
• Brayan Rocchio leads the Guardians with an OPS of .779. He has a slash line of .287/.369/.409 this season.
• Angel Martinez has 42 hits, which is tops among Cleveland hitters this season, while batting .246 with 19 extra-base hits.

Nationals Player Leaders

• C.J. Abrams has totaled 57 hits with a .545 slugging percentage, both team-high numbers for the Nationals. He's batting .288 and with an on-base percentage of .379.
• Including all qualifying hitters in the majors, he is 28th in batting average, 20th in on-base percentage and 11th in slugging percentage.
• James Wood paces his team with a .405 on-base percentage. He has a batting average of .267 while slugging .533.
• Including all qualified hitters, he is 56th in batting average, fourth in on-base percentage and 16th in slugging percentage.
• Daylen Lile has racked up a team-best .436 slugging percentage.
• Curtis Mead is batting .241 with eight doubles, seven home runs and 18 walks.

Guardians vs Nationals Head to Head

• 5/25/2026: 10-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/7/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/6/2025: 9-1 CLE (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/6/2025: 10-9 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/2/2024: 5-2 WSH (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/16/2023: 7-6 WSH (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 4/14/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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