Grizzlies vs. Cavaliers Prediction, Odds, Picks, Best Bets for April 6

Grizzlies vs. Cavaliers Game Info

• Date: Monday, April 6, 2026
• Time: 8 p.m. ET
• Venue: FedExForum -- Memphis, Tennessee
• Coverage: FDSOH and FDSSE

The Memphis Grizzlies (25-53) are heavy underdogs (+14) as they attempt to stop a four-game losing streak when they host the Cleveland Cavaliers (49-29) at 8 p.m. ET on Monday, April 6, 2026 at FedExForum. The contest airs on FDSOH and FDSSE. The matchup has an over/under of 237.5.

Grizzlies vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Grizzlies vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (70.8%)

Grizzlies vs. Cavaliers Betting Trends

• The Cavaliers have gone 30-46-2 against the spread this season.
• The Grizzlies have played 78 games, with 35 wins against the spread.
• Cavaliers games have gone over the total 38 times this season.
• Grizzlies games this year have hit the over on 39 of 78 set point totals (50%).
• When playing at home, Cleveland sports the same winning percentage against the spread as it does on the road (.385).
• The Cavaliers have exceeded the total less often at home, hitting the over in 15 of 39 home matchups (38.5%). On the road, they have hit the over in 23 of 39 games (59%).
• In 2025-26 against the spread, Memphis has a better winning percentage at home (.475, 19-21-0 record) than away (.421, 16-20-2).
• In 2025-26, a higher percentage of the Grizzlies' games have finished above the over/under at home (55%, 22 of 40) than on the road (44.7%, 17 of 38).

Cavaliers Leaders

• Donovan Mitchell's numbers on the season are 27.8 points, 4.5 boards and 5.7 assists per game, shooting 48.1% from the field and 36.4% from beyond the arc, with an average of 3.2 made 3-pointers (fifth in league).
• James Harden averages 23.7 points, 4.9 rebounds and 8.1 assists, shooting 43.7% from the field and 37.5% from downtown, with 3.1 made treys per contest.
• Evan Mobley is averaging 18.1 points, 9 boards and 3.6 assists. Defensively, he averages 0.8 steals and 1.8 blocked shots (third in league).
• Jarrett Allen's numbers on the season are 15.4 points, 8.5 boards and 1.8 assists per game, shooting 64.1% from the field (fifth in league).
• Dennis Schroder is averaging 10.8 points, 2.7 boards and 4.8 assists. At the other end, he averages 0.8 steals and 0.2 blocked shots.

Grizzlies Leaders

• Cam Spencer is averaging 11.1 points, 2.6 boards and 5.5 assists for the Grizzlies.
• Cedric Coward's numbers on the season are 13.4 points, 5.9 rebounds and 2.8 assists per game. He is making 46.4% of his shots from the floor and 33.2% from 3-point range, with an average of 1.5 treys.
• Per game, GG Jackson gets the Grizzlies 12.5 points, 4.3 boards and 1.4 assists, plus 0.6 steals and 0.8 blocks.
• Walter Clayton Jr.'s numbers on the season are 7.7 points, 2 boards and 4 assists per contest. He is sinking 38.1% of his shots from the floor and 30.3% from beyond the arc, with an average of 1.1 triples.
• The Grizzlies are receiving 7.3 points, 3.7 boards and 0.9 assists per game from Taylor Hendricks.

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