Grizzlies vs. Cavaliers Prediction, Odds, Picks, Best Bets for April 6

Grizzlies vs. Cavaliers Game Info

• Date: Monday, April 6, 2026
• Time: 8 p.m. ET
• Venue: FedExForum -- Memphis, Tennessee
• Coverage: FDSOH and FDSSE

The Memphis Grizzlies (25-53) will attempt to stop a four-game losing streak when they host the Cleveland Cavaliers (49-29) on Monday, April 6, 2026 at FedExForum as heavy, 13.5-point underdogs. The game airs at 8 p.m. ET on FDSOH and FDSSE. The matchup has an over/under of 234.5.

Grizzlies vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Grizzlies vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (70.8%)

Grizzlies vs. Cavaliers Betting Trends

• The Cavaliers have covered the spread 30 times in 78 games with a set spread.
• The Grizzlies have 35 wins against the spread in 78 games this year.
• Games involving the Cavaliers have hit the over 38 times this season.
• Grizzlies games this season have gone over the point total 50% of the time (39 out of 78 games with a set point total).
• Cleveland has an identical winning percentage against the spread in home games (.385) as it does in road games.
• The Cavaliers have eclipsed the total less consistently at home, hitting the over in 15 of 39 home matchups (38.5%). In away games, they have hit the over in 23 of 39 games (59%).
• Memphis' winning percentage against the spread at home is .475 (19-21-0). On the road, it is .421 (16-20-2).
• In 2025-26, a higher percentage of the Grizzlies' games have finished above the over/under at home (55%, 22 of 40) than on the road (44.7%, 17 of 38).

Cavaliers Leaders

• Donovan Mitchell averages 27.8 points, 4.5 boards and 5.7 assists.
• James Harden averages 23.7 points, 4.9 boards and 8.1 assists, shooting 43.7% from the field and 37.5% from beyond the arc, with 3.1 made treys per game.
• Evan Mobley is averaging 18.1 points, 9 rebounds and 3.6 assists. At the other end, he averages 0.8 steals and 1.8 blocked shots (third in league).
• Jarrett Allen is averaging 15.4 points, 1.8 assists and 8.5 boards.
• Dennis Schroder is averaging 10.8 points, 2.7 boards and 4.8 assists.

Grizzlies Leaders

• Per game, Cam Spencer provides the Grizzlies 11.1 points, 2.6 rebounds and 5.5 assists. He also averages 0.7 steals and 0.2 blocks.
• Cedric Coward averages 13.4 points, 5.9 rebounds and 2.8 assists. He is also making 46.4% of his shots from the field and 33.2% from beyond the arc, with 1.5 treys per game.
• The Grizzlies get 12.5 points per game from GG Jackson, plus 4.3 rebounds and 1.4 assists.
• The Grizzlies get 7.7 points per game from Walter Clayton Jr., plus 2 rebounds and 4 assists.
• Taylor Hendricks' numbers on the season are 7.3 points, 3.7 boards and 0.9 assists per game. He is making 45.2% of his shots from the field and 33.7% from 3-point range, with an average of 1.1 treys.

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