Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 13

Odds updated as of 2:11 p.m.

In MLB action on Wednesday, the San Francisco Giants face the San Diego Padres.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Padres Game Info

• San Francisco Giants (59-61) vs. San Diego Padres (68-52)
• Date: Wednesday, August 13, 2025
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SDPA

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-118) | SD: (-100)
• Spread: SF: +1.5 (-215) | SD: -1.5 (+176)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Kai-Wei Teng (Giants) - 1-1, 5.40 ERA vs Nick Pivetta (Padres) - 11-4, 2.94 ERA

The probable starters are Kai-Wei Teng (1-1) for the Giants and Nick Pivetta (11-4) for the Padres. Teng and his team failed to cover the spread in his only opportunity this season as a starter. Teng has yet to start a game this season when his team was the moneyline favorite. The Padres have gone 13-10-0 against the spread when Pivetta starts. The Padres are 5-3 in Pivetta's eight starts this season that they were the underdog on the moneyline.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.2%)

Giants vs Padres Moneyline

• San Francisco is a -118 favorite on the moneyline, while San Diego is a -100 underdog on the road.

Giants vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Giants. The Padres are +176 to cover, while the Giants are -215 to cover as a 1.5-run underdog on the runline.

Giants vs Padres Over/Under

• A combined run total of 7.5 has been set for Giants-Padres on Aug. 13, with the over at -112 and the under at -108.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have been chosen as favorites in 76 games this year and have walked away with the win 38 times (50%) in those games.
• This year San Francisco has won 36 of 70 games when listed as at least -118 on the moneyline.
• Contests with the Giants have gone over the total set by oddsmakers in 53 of 120 chances this season.
• The Giants have posted a record of 50-70-0 against the spread this season.
• The Padres have been the moneyline underdog 53 total times this season. They've finished 27-26 in those games.
• San Diego has a 24-23 record (winning 51.1% of its games) when playing as a moneyline underdog of -100 or longer.
• The Padres have had an over/under set by bookmakers 118 times, and have combined with opponents to go over the total in 50 of those games (50-65-3).
• The Padres have collected a 65-53-0 record against the spread this season (covering 55.1% of the time).

Giants Player Leaders

• Rafael Devers has 115 hits and an OBP of .379, both of which are best among San Francisco hitters this season. He has a .256 batting average and a slugging percentage of .469.
• Among all qualifying hitters in MLB, he ranks 84th in batting average, 10th in on-base percentage, and 41st in slugging.
• Devers has recorded a base hit in two games in a row. In his last five games he is batting .278 with three home runs, three walks and three RBIs.
• Jung Hoo Lee is hitting .256 with 27 doubles, nine triples, six home runs and 38 walks, while slugging .403 with an on-base percentage of .321.
• He ranks 84th in batting average, 96th in on-base percentage and 101st in slugging in the majors.
• Lee heads into this game looking to extend his two-game hit streak. In his last five games he is batting .222 with .
• Willy Adames has collected 100 base hits, an OBP of .311 and a slugging percentage of .396 this season.
• Heliot Ramos has an OPS of .750, fueled by an OBP of .342 and a team-best slugging percentage of .407 this season.

Padres Player Leaders

• Manny Machado has racked up 137 hits with a .489 slugging percentage, both team-high numbers for the Padres. He's batting .297 and with an on-base percentage of .359.
• Including all qualifying players in MLB, his batting average puts him ninth, his on-base percentage is 28th, and he is 26th in slugging.
• Machado brings a three-game hitting streak into this game. During his last five outings he is batting .222 with four walks.
• Fernando Tatis Jr. is batting .263 with 21 doubles, two triples, 17 home runs and 67 walks. He's slugging .433 with an on-base percentage of .366.
• Including all qualified hitters, his batting average puts him 67th, his on-base percentage ranks 20th, and he is 75th in slugging.
• Luis Arraez has 23 doubles, four triples, six home runs and 25 walks while hitting .290.
• Xander Bogaerts is batting .268 with 26 doubles, 10 home runs and 46 walks.

Giants vs Padres Head to Head

• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2025: 3-2 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/2/2025: 1-0 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/30/2025: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/29/2025: 7-4 SD (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2024: 4-3 SD (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/14/2024: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!