Illinois vs Purdue Prediction, Odds, Picks, Best Bets for Week 6 2025

The Illinois Fighting Illini will take on the Purdue Boilermakers in college football action on Saturday.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Illinois vs Purdue Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-370) | Purdue: (+295)
• Spread: Illinois: -8.5 (-115) | Purdue: +8.5 (-105)
• Total: 54.5 -- Over: (-112) | Under: (-108)

Illinois vs Purdue Betting Trends

• Illinois has four wins in five games against the spread this year.
• Illinois has covered every time (2-0) as an 8.5-point favorite or greater this season.
• Illinois has played five games this season, and three of them have hit the over.
• Purdue has won twice against the spread this season.
• Purdue has one win ATS (1-1) as an 8.5-point underdog or more this year.
• Purdue has had one game (of four) go over the total this season.

Illinois vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (78.4%)

Illinois vs Purdue Point Spread

Purdue is an underdog by 8.5 points versus Illinois. Purdue is -105 to cover the spread, and Illinois is -115.

Illinois vs Purdue Over/Under

Illinois versus Purdue, on Oct. 4, has an over/under of 54.5, with the over being -112 and the under -108.

Illinois vs Purdue Moneyline

Looking at the moneyline for Purdue-Illinois, Purdue is the underdog at +295, and Illinois is -370.

Illinois vs. Purdue Points Insights

Illinois vs. Purdue Game Info

• Game day: Saturday, October 4, 2025
• Game time: 12 p.m. ET
• TV channel: BTN
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Illinois vs. Purdue analysis on FanDuel Research.