Clemson vs North Carolina Prediction, Odds, Picks, Best Bets for Week 6 2025

The college football schedule on Saturday includes the Clemson Tigers facing the North Carolina Tar Heels.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Clemson vs North Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-699) | North Carolina: (+500)
• Spread: Clemson: -14.5 (-112) | North Carolina: +14.5 (-108)
• Total: 47.5 -- Over: (-105) | Under: (-115)

Clemson vs North Carolina Betting Trends

• Clemson has no wins against the spread this year.
• Clemson has no wins ATS (0-2) as a 14.5-point favorite or greater this year.
• One of four Clemson games have hit the over this year.
• North Carolina has posted two wins against the spread this season.
• One of North Carolina's four games has hit the over.

Clemson vs North Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (68.1%)

Clemson vs North Carolina Point Spread

Clemson is favored by 14.5 points over North Carolina. Clemson is -112 to cover the spread, with North Carolina being -108.

Clemson vs North Carolina Over/Under

Clemson versus North Carolina, on Oct. 4, has an over/under of 47.5, with the over being -105 and the under -115.

Clemson vs North Carolina Moneyline

Looking at the moneyline for Clemson-North Carolina, Clemson is the favorite at -699, and North Carolina is +500.

Clemson vs. North Carolina Points Insights

Clemson vs. North Carolina Game Info

• Game day: Saturday, October 4, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Chapel Hill, North Carolina
• Stadium: Kenan Stadium

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Check out even more in-depth Clemson vs. North Carolina analysis on FanDuel Research.