Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 3:11 p.m.

On Wednesday in MLB, the San Francisco Giants are playing the San Diego Padres.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Padres Game Info

• San Francisco Giants (14-22) vs. San Diego Padres (21-14)
• Date: Wednesday, May 6, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-142) | SD: (+120)
• Spread: SF: -1.5 (+146) | SD: +1.5 (-176)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Giants) - 0-3, 7.12 ERA vs Bradgley Rodriguez (Padres) - 0-1, 1.62 ERA

The Giants will give the nod to Adrian Houser (0-3) against the Padres and Bradgley Rodriguez (0-1). Houser and his team have a record of 1-5-0 against the spread when he starts. Houser's team won his only start as a favorite this season. Rodriguez's team was never a moneyline underdog a season ago in games he pitched.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (51.3%)

Giants vs Padres Moneyline

• San Diego is the underdog, +120 on the moneyline, while San Francisco is a -142 favorite at home.

Giants vs Padres Spread

• The Padres are at +1.5 on the runline against the Giants. The Padres are -176 to cover the spread, and the Giants are +146.

Giants vs Padres Over/Under

• Giants versus Padres on May 6 has an over/under of 7.5 runs, with the odds on the over -105 and the under set at -115.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have come away with five wins in the 12 contests they have been listed as the favorites in this season.
• This season San Francisco has been victorious one time in three chances when named as a favorite of at least -142 on the moneyline.
• The Giants and their opponents have gone over in 15 of their 36 games with a total set by sportsbooks this season.
• The Giants have posted a record of 15-21-0 against the spread this season.
• The Padres have won seven of the 13 games they were the moneyline underdog this season (53.8%).
• When playing as a moneyline underdog with odds of +120 or longer, San Diego has a record of 2-1 (66.7%).
• In the 35 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 16 times (16-18-1).
• The Padres have a 20-15-0 record ATS this season (covering 57.1% of the time).

Giants Player Leaders

• Luis Arraez leads San Francisco in slugging percentage (.398) thanks to nine extra-base hits. He has a .316 batting average and an on-base percentage of .340.
• Among qualifying batters in the majors, his batting average ranks 16th, his on-base percentage ranks 71st, and he is 91st in slugging.
• Casey Schmitt leads San Francisco with 34 hits and an OBP of .355 this season. He's batting .306 and slugging .559.
• Among all qualified, he ranks 23rd in batting average, 60th in on-base percentage and 14th in slugging percentage.
• Schmitt brings a seven-game streak with at least one hit into this one. During his last 10 games he is hitting .361 with a double, a triple, four home runs, three walks and 10 RBIs.
• Jung Hoo Lee has 35 hits this season and has a slash line of .271/.319/.395.
• Matt Chapman has been key for San Francisco with 32 hits, an OBP of .315 plus a slugging percentage of .321.

Padres Player Leaders

• Xander Bogaerts has accumulated a team-best OBP (.352) and slugging percentage (.429), and paces the Padres in hits (34, while batting .270).
• Including all the qualified hitters in the big leagues, his batting average is 52nd, his on-base percentage is 63rd, and he is 66th in slugging.
• Jackson Merrill has seven doubles, four home runs and 10 walks while batting .235. He's slugging .379 with an on-base percentage of .294.
• He is currently 114th in batting average, 143rd in on-base percentage and 109th in slugging percentage among all qualifying hitters.
• Manny Machado is hitting .212 with four doubles, five home runs and 19 walks.
• Ramon Laureano has four doubles, two triples, five home runs and 11 walks while batting .238.

Giants vs Padres Head to Head

• 5/5/2026: 10-5 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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