Dodgers vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 1:11 p.m.

The Los Angeles Dodgers will face the Houston Astros in MLB action on Wednesday.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Dodgers vs Astros Game Info

• Los Angeles Dodgers (22-14) vs. Houston Astros (15-22)
• Date: Wednesday, May 6, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and SportsNet LA

Dodgers vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-220) | HOU: (+184)
• Spread: LAD: -1.5 (-132) | HOU: +1.5 (+110)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Dodgers vs Astros Probable Starting Pitchers

Probable Pitchers: Tyler Glasnow (Dodgers) - 3-0, 2.56 ERA vs Lance McCullers (Astros) - 2-2, 6.32 ERA

This contest's pitching matchup is set, as the Dodgers will send Tyler Glasnow (3-0) to the mound, while Lance McCullers (2-2) will answer the bell for the Astros. When Glasnow starts, his team is 3-3-0 against the spread this season. Glasnow's team has won 83.3% of his starts when they are favored on the moneyline (5-1). When McCullers starts, the Astros have gone 3-3-0 against the spread. The Astros have been the moneyline underdog in four of McCullers' starts this season, and they went 2-2 in those games.

Dodgers vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (58%)

Dodgers vs Astros Moneyline

• Looking at the moneyline for Dodgers-Astros, Los Angeles is the favorite at -220, and Houston is +184 playing at home.

Dodgers vs Astros Spread

• The Dodgers are at the Astros and are favored by 1.5 runs on the spread. The Dodgers are -132 to cover the runline, with the Astros being +110.

Dodgers vs Astros Over/Under

• A combined run total of 8.5 has been set for Dodgers-Astros on May 6, with the over at -106 and the under at -114.

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Dodgers vs Astros Betting Trends

• The Dodgers have been chosen as favorites in 36 games this year and have walked away with the win 22 times (61.1%) in those games.
• Los Angeles has a record of 10-5 in contests when sportsbooks favor them by -220 or more on the moneyline.
• The Dodgers and their opponents have hit the over in 16 of their 36 games with a total set by oddsmakers this season.
• The Dodgers have an against the spread mark of 17-19-0 in 36 games with a line this season.
• The Astros have won 45% of the games this season they were the underdog on the moneyline (9-11).
• Houston has yet to play a game with moneyline odds of +184 or longer.
• The Astros have had an over/under set by oddsmakers 37 times, and have combined with opponents to go over the total in 24 of those games (24-12-1).
• The Astros have collected a 15-22-0 record against the spread this season (covering 40.5% of the time).

Dodgers Player Leaders

• Andy Pages has an OPS of .868, fueled by an OBP of .368 and a team-best slugging percentage of .500 this season. He has a .326 batting average.
• Among qualified batters in MLB, he ranks ninth in batting average, 43rd in on-base percentage, and 31st in slugging.
• Pages will look for his eighth straight game with a hit in this matchup. In his last 10 outings he is batting .308 with three doubles, two walks and six RBIs.
• Max Muncy has 33 hits and an OBP of .390, both of which lead the Dodgers this season. He's batting .284 and slugging .560.
• Among qualified hitters, his batting average ranks him 40th, his on-base percentage 19th, and his slugging percentage 13th.
• Shohei Ohtani has 30 hits this season and has a slash line of .240/.382/.432.
• Kyle Tucker has been key for Los Angeles with 33 hits, an OBP of .329 plus a slugging percentage of .385.
• Tucker has safely hit in four straight games. In his last five games he is batting .263 with a double, a home run, two walks and four RBIs.

Astros Player Leaders

• Yordan Alvarez has racked up an on-base percentage of .428, a slugging percentage of .647, and has 45 hits, all club-highs for the Astros (while batting .324).
• Including all the qualifying hitters in the big leagues, his batting average ranks 10th, his on-base percentage ranks fifth, and he is fourth in slugging.
• Christian Walker has nine doubles, nine home runs and 15 walks while hitting .308. He's slugging .579 with an on-base percentage of .384.
• His batting average is 19th among all qualified players, his on-base percentage is 25th, and he is ninth in slugging.
• Carlos Correa has eight doubles, three home runs and 18 walks while batting .279.
• Jose Altuve is hitting .241 with nine doubles, three home runs and 17 walks.

Dodgers vs Astros Head to Head

• 5/5/2026: 2-1 HOU (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/4/2026: 8-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/6/2025: 5-1 HOU (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/5/2025: 6-4 HOU (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/4/2025: 18-1 HOU (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 7/28/2024: 6-2 LAD (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/27/2024: 7-6 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/26/2024: 5-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/25/2023: 6-5 HOU (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/24/2023: 8-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)

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