Angels vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 3:11 p.m.

The Wednesday slate in MLB includes a matchup between the Los Angeles Angels and the Chicago White Sox.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Angels vs White Sox Game Info

• Los Angeles Angels (14-23) vs. Chicago White Sox (17-19)
• Date: Wednesday, May 6, 2026
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and CHSN

Angels vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-116) | CHW: (-102)
• Spread: LAA: +1.5 (-192) | CHW: -1.5 (+158)
• Total: 9 -- Over: (-110) | Under: (-110)

Angels vs White Sox Probable Starting Pitchers

Probable Pitchers: Walbert Urena (Angels) - 0-3, 3.86 ERA vs Noah Schultz (White Sox) - 2-1, 2.53 ERA

This contest's pitching matchup is set, as the Angels will send Walbert Urena (0-3) to the mound, while Noah Schultz (2-1) will get the nod for the White Sox. Urena and his team have a record of 2-1-0 against the spread when he starts. This will be Urena's first start this season with his team as the moneyline favorite. The White Sox have a 2-2-0 ATS record in Schultz's four starts that had a set spread. The White Sox are 2-1 in Schultz's three starts this season that they were the moneyline underdog.

Angels vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (52%)

Angels vs White Sox Moneyline

• Chicago is the underdog, -102 on the moneyline, while Los Angeles is a -116 favorite at home.

Angels vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Angels. The White Sox are +158 to cover, while the Angels are -192 to cover as a 1.5-run underdog on the runline.

Angels vs White Sox Over/Under

• Angels versus White Sox on May 6 has an over/under of 9 runs, with the odds on the over -110 and the under set at -110.

Bet on Los Angeles Angels vs. Chicago White Sox on FanDuel today!

Angels vs White Sox Betting Trends

• The Angels have been chosen as favorites in seven games this year and have walked away with the win three times (42.9%) in those games.
• Los Angeles has a record of 3-3 when favored by -116 or more this year.
• The Angels and their opponents have gone over in 16 of their 36 games with a total set by sportsbooks this season.
• The Angels have an against the spread mark of 18-18-0 in 36 games with a line this season.
• The White Sox have put together a 14-17 record in games they were listed as the moneyline underdog (winning 45.2% of those games).
• Chicago is 14-15 (winning 48.3% of its games) when it has played as a moneyline underdog of -102 or longer.
• The White Sox have had an over/under set by oddsmakers 34 times, and have combined with opponents to go over the total in 17 of those games (17-17-0).
• The White Sox have covered 55.9% of their games this season, going 19-15-0 against the spread.

Angels Player Leaders

• Mike Trout leads Los Angeles in OBP (.436) and total hits (33) this season. He's batting .262 batting average while slugging .563.
• He is 65th in batting average, second in on-base percentage, and 12th in slugging among qualifying batters in MLB.
• Jorge Soler is hitting .231 with five doubles, eight home runs and 15 walks, while slugging .471 with an on-base percentage of .324.
• His batting average is 120th among qualified players, his on-base percentage 100th, and his slugging percentage 45th.
• Zach Neto has collected 32 base hits, an OBP of .327 and a slugging percentage of .395 this season.
• Nolan Schanuel has three home runs, 20 RBI and a batting average of .256 this season.
• Schanuel has hit safely in five games in a row. In his last five games he is hitting .350 with three doubles and an RBI.

White Sox Player Leaders

• Munetaka Murakami has put up a team-best OBP (.378), and leads the White Sox in hits (31). He's batting .244 and slugging.
• He ranks 95th in batting average, 32nd in on-base percentage and eighth in slugging percentage among all qualifying hitters in the big leagues.
• Miguel Vargas is hitting .222 with four doubles, a triple, seven home runs and 26 walks. He's slugging .437 with an on-base percentage of .361.
• Including all qualified players, his batting average puts him 132nd, his on-base percentage ranks 52nd, and he is 58th in slugging.
• Colson Montgomery has six doubles, nine home runs and 15 walks while batting .227.
• Chase Meidroth is slugging .369 to pace his team.

Angels vs White Sox Head to Head

• 5/5/2026: 4-3 LAA (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2026: 6-0 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/29/2026: 3-2 CHW (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/28/2026: 5-2 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/3/2025: 8-5 LAA (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/2/2025: 1-0 CHW (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 8/1/2025: 6-3 CHW (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 3-2 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 3/29/2025: 1-0 LAA (Favorite: Angels, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 3/27/2025: 8-1 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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