Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 9:11 p.m.

MLB action on Tuesday includes the San Francisco Giants facing the San Diego Padres.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Giants vs Padres Game Info

• San Francisco Giants (14-21) vs. San Diego Padres (20-14)
• Date: Tuesday, May 5, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-142) | SD: (+120)
• Spread: SF: -1.5 (+146) | SD: +1.5 (-176)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 2-3, 4.30 ERA vs Walker Buehler (Padres) - 1-2, 5.40 ERA

The probable starters are Logan Webb (2-3) for the Giants and Walker Buehler (1-2) for the Padres. Webb's team is 3-4-0 against the spread this season in his starts. When Webb starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Padres have gone 4-2-0 against the spread when Buehler starts. The Padres are 2-1 in Buehler's three starts this season that they were the moneyline underdog.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (56.8%)

Giants vs Padres Moneyline

• San Diego is a +120 underdog on the moneyline, while San Francisco is a -142 favorite at home.

Giants vs Padres Spread

• The Giants are hosting the Padres and are favored by 1.5 runs (+146 to cover) on the runline. San Diego is -176 to cover.

Giants vs Padres Over/Under

• Giants versus Padres on May 5 has an over/under of 7.5 runs, with the odds on the over -105 and the under set at -115.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have been favorites in 11 games this season and have come away with the win five times (45.5%) in those contests.
• San Francisco has been listed as a favorite of -142 or more on two occasions this season and split those games.
• Contests with the Giants have gone over the total set by sportsbooks in 14 of 35 chances this season.
• The Giants are 15-20-0 against the spread in their 35 games with a line set by sportsbooks this season.
• The Padres have won 50% of the games this season they were the moneyline underdog (6-6).
• San Diego has a 2-1 record (winning 66.7% of its games) when playing as a moneyline underdog of +120 or longer.
• The Padres have played in 34 games with an over/under set, and have combined with opponents to go over the total 15 times (15-18-1).
• The Padres are 19-15-0 against the spread this season.

Giants Player Leaders

• Luis Arraez leads San Francisco with a slugging percentage of .398, fueled by nine extra-base hits. He has a .316 batting average and an on-base percentage of .340.
• Among qualified batters in the majors, his batting average ranks 14th, his on-base percentage ranks 71st, and he is 97th in slugging.
• Casey Schmitt leads the Giants in OBP (.359) and total hits (33) this season. He's batting .308 while slugging .542.
• Among all qualifying hitters, he ranks 20th in batting average, 54th in on-base percentage and 15th in slugging percentage.
• Schmitt heads into this matchup looking to extend his six-game hit streak. During his last 10 outings he is batting .361 with a double, a triple, three home runs, three walks and eight RBIs.
• Jung Hoo Lee has collected 34 base hits, an OBP of .321 and a slugging percentage of .400 this season.
• Matt Chapman has one home run, 12 RBI and a batting average of .246 this season.

Padres Player Leaders

• Xander Bogaerts has a .343 on-base percentage and a .402 slugging percentage, both team-high numbers for the Padres. He's batting .262.
• He is 62nd in batting average, 69th in on-base percentage and 90th in slugging percentage among all qualified hitters in the majors.
• Manny Machado is batting .221 with four doubles, five home runs and 19 walks. He's slugging .389 with an on-base percentage of .328.
• His batting average is 132nd among all qualified players, his on-base percentage ranks 87th, and he is 104th in slugging.
• Jackson Merrill is hitting .220 with six doubles, four home runs and 10 walks.
• Ramon Laureano leads his team with 29 hits.

Giants vs Padres Head to Head

• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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