Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 5:12 a.m.

The Tuesday schedule in MLB includes a matchup between the San Francisco Giants and the San Diego Padres.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Giants vs Padres Game Info

• San Francisco Giants (14-21) vs. San Diego Padres (20-14)
• Date: Tuesday, May 5, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-136) | SD: (+116)
• Spread: SF: -1.5 (+152) | SD: +1.5 (-184)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 2-3, 4.30 ERA vs Walker Buehler (Padres) - 1-2, 5.40 ERA

The probable starters are Logan Webb (2-3) for the Giants and Walker Buehler (1-2) for the Padres. When Webb starts, his team is 3-4-0 against the spread this season. When Webb starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Padres have a 4-2-0 record against the spread in Buehler's starts. The Padres have a 2-1 record in Buehler's three starts this season when they were the moneyline underdog.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (60.5%)

Giants vs Padres Moneyline

• San Diego is the underdog, +116 on the moneyline, while San Francisco is a -136 favorite at home.

Giants vs Padres Spread

• The Padres are +1.5 on the spread (-184 to cover), and San Francisco is +152 to cover the runline.

Giants vs Padres Over/Under

• Giants versus Padres, on May 5, has an over/under of 7.5, with the over being -105 and the under -115.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have come away with five wins in the 11 contests they have been listed as the favorites in this season.
• This year San Francisco has won two of three games when listed as at least -136 on the moneyline.
• The Giants and their opponents have hit the over in 14 of their 35 games with a total set by oddsmakers this season.
• The Giants are 15-20-0 against the spread in their 35 games that had a posted line this season.
• The Padres are 6-6 in games they were the underdog on the moneyline (winning 50% of those games).
• San Diego is 2-2 (winning 50% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Padres have played in 34 games with an over/under set, and have combined with opponents to go over the total 15 times (15-18-1).
• The Padres have covered 55.9% of their games this season, going 19-15-0 against the spread.

Giants Player Leaders

• Luis Arraez has an OPS of .739, fueled by an OBP of .340 and a team-best slugging percentage of .398 this season. He has a .316 batting average.
• Among qualifying hitters in the majors, he is 14th in batting average, 71st in on-base percentage, and 97th in slugging.
• Casey Schmitt leads San Francisco with 33 hits and an OBP of .359 this season. He's batting .308 and slugging .542.
• Among qualifying hitters, his batting average ranks him 20th, his on-base percentage 54th, and his slugging percentage 15th.
• Schmitt heads into this matchup looking to extend his six-game hit streak. During his last 10 outings he is hitting .361 with a double, a triple, three home runs, three walks and eight RBIs.
• Jung Hoo Lee has collected 34 base hits, an OBP of .321 and a slugging percentage of .400 this season.
• Matt Chapman has been key for San Francisco with 32 hits, an OBP of .324 plus a slugging percentage of .331.

Padres Player Leaders

• Xander Bogaerts has racked up an on-base percentage of .343 and a slugging percentage of .402. Both lead the Padres. He's batting .262.
• Including all the qualified players in MLB, his batting average ranks 62nd, his on-base percentage is 69th, and he is 90th in slugging.
• Manny Machado is hitting .221 with four doubles, five home runs and 19 walks. He's slugging .389 with an on-base percentage of .328.
• He is currently 132nd in batting average, 87th in on-base percentage and 104th in slugging percentage among all qualifying hitters.
• Jackson Merrill is batting .220 with six doubles, four home runs and 10 walks.
• Ramon Laureano's 29 hits pace his team.

Giants vs Padres Head to Head

• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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