Giants vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 3:12 p.m.

The Arizona Diamondbacks are among the MLB teams playing on Wednesday, versus the San Francisco Giants.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (30-24) vs. San Francisco Giants (22-33)
• Date: Wednesday, May 27, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Dbacks.TV

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-118) | SF: (+100)
• Spread: ARI: -1.5 (+142) | SF: +1.5 (-172)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Mike Soroka (Diamondbacks) - 6-2, 3.27 ERA vs Trevor McDonald (Giants) - 2-1, 4.76 ERA

The probable pitchers are Mike Soroka (6-2) for the Diamondbacks and Trevor McDonald (2-1) for the Giants. Soroka's team is 5-4-0 against the spread in his starts this season. When Soroka starts a game and his team is the favorite on the moneyline, they have a record of 3-2. The Giants have a 3-1-0 record against the spread in McDonald's starts. The Giants are 3-1 in McDonald's four starts this season that they were the moneyline underdog.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (51%)

Diamondbacks vs Giants Moneyline

• The moneyline numbers for Diamondbacks vs. Giants reveal Arizona as the favorite (-118) and San Francisco as the underdog (+100) despite being the home team.

Diamondbacks vs Giants Spread

• The Diamondbacks are at the Giants and are favored by 1.5 runs (+142 to cover) on the runline. San Francisco is -172 to cover.

Diamondbacks vs Giants Over/Under

• The over/under for the Diamondbacks versus Giants game on May 27 has been set at 7.5, with -112 odds on the over and -108 odds on the under.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have been victorious in 15, or 68.2%, of the 22 contests they have been chosen as favorites in this season.
• This season Arizona has come away with a win 12 times in 16 chances when named as a favorite of at least -118 on the moneyline.
• The Diamondbacks' games have gone over the total in 27 of their 53 opportunities.
• The Diamondbacks are 32-21-0 against the spread in their 53 games that had a posted line this season.
• The Giants have won 13 of the 37 games they were listed as the moneyline underdog this season (35.1%).
• In games it has played as a moneyline underdog with odds of +100 or longer, San Francisco has an 11-17 record (winning just 39.3% of its games).
• In the 55 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 27 times (27-25-3).
• The Giants have covered 40% of their games this season, going 22-33-0 against the spread.

Diamondbacks Player Leaders

• Corbin Carroll leads Arizona with 55 hits and an OBP of .399 this season. He has a .299 batting average and a slugging percentage of .565.
• Among qualifying hitters in baseball, he is 15th in batting average, seventh in on-base percentage, and seventh in slugging.
• Ketel Marte leads Arizona in slugging percentage (.478) thanks to 22 extra-base hits. He's batting .273 with an on-base percentage of .324.
• Among qualifying batters, he is 46th in batting average, 92nd in on-base percentage and 33rd in slugging percentage.
• Marte heads into this matchup looking to extend his 10-game hit streak. During his last 10 outings he is batting .524 with six doubles, four home runs, four walks and 17 RBIs.
• Ildemaro Vargas has hit seven homers with a team-high .486 SLG this season.
• Nolan Arenado has seven home runs, 27 RBI and a batting average of .271 this season.

Giants Player Leaders

• Luis Arraez has a team-high OBP (.359) and slugging percentage (.426). He's batting .317.
• Including all qualifying hitters in MLB, his batting average places him fourth, his on-base percentage ranks 40th, and he is 70th in slugging.
• Casey Schmitt paces his team with 53 hits. He has a batting average of .298 while slugging .567 with an on-base percentage of .339.
• His batting average is 19th among all qualified players, his on-base percentage ranks 72nd, and he is fifth in slugging.
• Rafael Devers is hitting .246 with 15 doubles, seven home runs and 13 walks.
• Willy Adames is hitting .239 with 15 doubles, a triple, seven home runs and 11 walks.

Diamondbacks vs Giants Head to Head

• 5/26/2026: 7-5 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/25/2026: 6-2 ARI (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/20/2026: 6-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/19/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/18/2026: 12-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/17/2025: 5-1 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/16/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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