Giants vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 12:12 a.m.

The MLB's Wednesday schedule includes the San Francisco Giants taking on the Arizona Diamondbacks.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Giants vs Diamondbacks Game Info

• San Francisco Giants (22-32) vs. Arizona Diamondbacks (29-24)
• Date: Wednesday, May 27, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Dbacks.TV

Giants vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-110) | ARI: (-106)
• Spread: SF: +1.5 (-192) | ARI: -1.5 (+158)
• Total: 8 -- Over: (-115) | Under: (-105)

Giants vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Trevor McDonald (Giants) - 2-1, 4.76 ERA vs Mike Soroka (Diamondbacks) - 6-2, 3.27 ERA

This contest's pitching matchup is set, as the Giants will send Trevor McDonald (2-1) to the mound, while Mike Soroka (6-2) will answer the bell for the Diamondbacks. McDonald and his team are 3-1-0 ATS this season when he starts. This will be McDonald's first start this season with his team as the moneyline favorite. The Diamondbacks have gone 5-4-0 against the spread when Soroka starts. The Diamondbacks have been the underdog on the moneyline in three of Soroka's starts this season, and they went 1-2 in those games.

Giants vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (50.2%)

Giants vs Diamondbacks Moneyline

• Looking at the moneyline for Diamondbacks-Giants, Arizona is the underdog at -106, and San Francisco is -110 playing at home.

Giants vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Giants. The Diamondbacks are +158 to cover, while the Giants are -192 to cover as a 1.5-run underdog on the runline.

Giants vs Diamondbacks Over/Under

• The over/under for the Giants versus Diamondbacks game on May 27 has been set at 8, with -115 odds on the over and -105 odds on the under.

Bet on San Francisco Giants vs. Arizona Diamondbacks on FanDuel today!

Giants vs Diamondbacks Betting Trends

• The Giants have been victorious in eight, or 50%, of the 16 contests they have been chosen as favorites in this season.
• San Francisco has a record of 8-8 in contests when bookmakers favor them by -110 or more on the moneyline.
• Contests with the Giants have gone over the total set by sportsbooks in 26 of 54 chances this season.
• In 54 games with a line this season, the Giants have a mark of 22-32-0 against the spread.
• The Diamondbacks have compiled a 10-17 record in games they were the underdog on the moneyline (winning 37% of those games).
• When playing as a moneyline underdog with odds of -106 or longer, Arizona has a record of 10-17 (37%).
• The Diamondbacks have had an over/under set by bookmakers 52 times, and have combined with opponents to go over the total in 26 of those games (26-24-2).
• The Diamondbacks have put together a 31-21-0 record against the spread this season (covering 59.6% of the time).

Giants Player Leaders

• Luis Arraez has an OPS of .789, fueled by an OBP of .361 to go with a slugging percentage of .428. He has a .318 batting average, as well.
• Among qualifying hitters in baseball, his batting average ranks third, his on-base percentage ranks 34th, and he is 68th in slugging.
• Casey Schmitt leads San Francisco in total hits (51) this season while batting .295 with 22 extra-base hits. He's slugging .555 with an on-base percentage of .337.
• His batting average ranks 22nd among qualified players, his on-base percentage 74th, and his slugging percentage ninth.
• Schmitt has picked up a hit in three straight games. In his last five games he is hitting .300 with two doubles, three home runs, a walk and eight RBIs.
• Rafael Devers has 51 hits this season and has a slash line of .246/.291/.415.
• Devers has recorded at least one base hit in three straight games. In his last five games he is hitting .250 with three doubles, a home run and seven RBIs.
• Willy Adames is batting .235 with a .276 OBP and 17 RBI for San Francisco this season.
• Adames brings a four-game hitting streak into this game. In his last five games he is hitting .190 with a double, a home run, two walks and two RBIs.

Diamondbacks Player Leaders

• Corbin Carroll has an on-base percentage of .399, a slugging percentage of .575, and has 55 hits, all club-highs for the Diamondbacks (while batting .304).
• He is eighth in batting average, seventh in on-base percentage and fifth in slugging percentage among all qualified batters in MLB.
• Carroll enters this matchup on a 13-game hitting streak. In his last 10 outings he is batting .429 with two doubles, four triples, two home runs, four walks and eight RBIs.
• Ketel Marte paces his team with a .470 slugging percentage. He has a batting average of .275 with an on-base percentage of .327.
• Including all qualified hitters, he is 46th in batting average, 86th in on-base percentage and 38th in slugging percentage.
• Ildemaro Vargas has racked up a slugging percentage of .486, a team-high for the Diamondbacks.
• Nolan Arenado has 11 doubles, seven home runs and 17 walks while hitting .268.

Giants vs Diamondbacks Head to Head

• 5/25/2026: 6-2 ARI (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/20/2026: 6-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/19/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/18/2026: 12-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/17/2025: 5-1 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/16/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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