Duke vs Syracuse Prediction, Odds, Picks, Best Bets for Week 5 2025

Saturday's slate in college football includes a matchup between the Duke Blue Devils and the Syracuse Orange.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Duke vs Syracuse Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Duke: (-196) | Syracuse: (+162)
• Spread: Duke: -4.5 (-115) | Syracuse: +4.5 (-105)
• Total: 58.5 -- Over: (-115) | Under: (-105)

Duke vs Syracuse Betting Trends

• Duke has one win against the spread this season.
• Duke has no wins ATS (0-1) as a 4.5-point favorite or greater this season.
• Duke and its opponent have not failed to hit the over in any game this season.
• Syracuse has posted two wins against the spread this year.
• As a 4.5-point underdog or more, Syracuse has one win ATS (1-1) this season.
• There have been three Syracuse games (out of four) that hit the over this season.

Duke vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Blue Devils win (59.5%)

Duke vs Syracuse Point Spread

Duke is favored by 4.5 points against Syracuse. Duke is -115 to cover the spread, while Syracuse is -105.

Duke vs Syracuse Over/Under

A combined point total of 58.5 has been set for Duke-Syracuse on Sept. 27, with the over at -115 and the under at -105.

Duke vs Syracuse Moneyline

The moneyline numbers for Duke vs. Syracuse reveal Duke as the favorite (-196) and Syracuse as the underdog (+162).

Duke vs. Syracuse Points Insights

Duke vs. Syracuse Game Info

• Game day: Saturday, September 27, 2025
• Game time: 12 p.m. ET
• TV channel: ACC Network
• Location: Syracuse, New York
• Stadium: JMA Wireless Dome

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Duke vs. Syracuse analysis on FanDuel Research.