Dodgers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 5:16 a.m.

In MLB action on Friday, the Los Angeles Dodgers play the San Diego Padres.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Dodgers vs Padres Game Info

• Los Angeles Dodgers (73-55) vs. San Diego Padres (72-56)
• Date: Friday, August 22, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and SportsNet LA

Dodgers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-120) | SD: (+102)
• Spread: LAD: -1.5 (+146) | SD: +1.5 (-178)
• Total: 8 -- Over: (-110) | Under: (-110)

Dodgers vs Padres Probable Starting Pitchers

Probable Pitchers: Blake Snell (Dodgers) - 3-1, 1.80 ERA vs Yu Darvish (Padres) - 2-3, 5.97 ERA

This contest's pitching matchup is set, as the Dodgers will send Blake Snell (3-1) to the mound, while Yu Darvish (2-3) will answer the bell for the Padres. When Snell starts, his team is 2-3-0 against the spread this season. When Snell starts a game and his team is the favorite on the moneyline, they have a record of 4-1. When Darvish starts, the Padres have gone 5-2-0 against the spread. The Padres have a 2-2 record in Darvish's four starts this season when they were the moneyline underdog.

Dodgers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (51.8%)

Dodgers vs Padres Moneyline

• Looking at the moneyline for Padres-Dodgers, San Diego is the underdog at +102, and Los Angeles is -120 playing on the road.

Dodgers vs Padres Spread

• The Padres are hosting the Dodgers, and are +1.5 on the runline. The Padres are +146 to cover the spread, and the Dodgers are -178.

Dodgers vs Padres Over/Under

• The over/under for Dodgers-Padres on Aug. 22 is 8. The over is -110, and the under is -110.

Bet on Los Angeles Dodgers vs. San Diego Padres on FanDuel today!

Dodgers vs Padres Betting Trends

• The Dodgers have come away with 65 wins in the 111 contests they have been listed as the favorites in this season.
• This year Los Angeles has won 63 of 106 games when listed as at least -120 on the moneyline.
• Contests with the Dodgers have gone over the total set by sportsbooks in 64 of 126 chances this season.
• The Dodgers are 52-74-0 against the spread in their 126 games that had a posted line this season.
• The Padres have been the underdog on the moneyline 56 total times this season. They've finished 27-29 in those games.
• San Diego has a 23-25 record (winning 47.9% of its games) when playing as a moneyline underdog of +102 or longer.
• The Padres have played in 126 games with an over/under set, and have combined with their opponents to go over the total 54 times (54-69-3).
• The Padres have a 71-55-0 record ATS this season (covering 56.3% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles with 138 hits and a team-best slugging percentage of .625. He's batting .285 with an on-base percentage of .393.
• Among all qualifying hitters, he is 23rd in batting average, his on-base percentage ranks sixth, and he is second in slugging.
• Ohtani has recorded at least one hit in five games in a row. In his last five games he is batting .353 with a double, a home run, four walks and three RBIs.
• Mookie Betts is hitting .246 with 17 doubles, a triple, 13 home runs and 48 walks, while slugging .372 with an on-base percentage of .317.
• He ranks 110th in batting average, 104th in on-base percentage and 139th in slugging among qualifying batters.
• Betts heads into this game looking to extend his four-game hit streak. During his last five outings he is batting .316 with a home run, four walks and an RBI.
• Freddie Freeman has 132 hits this season and has a slash line of .306/.378/.495.
• Freeman has picked up a hit in six games in a row. During his last 10 games he is hitting .282 with three doubles, two home runs, three walks and six RBIs.
• Andy Pages has 21 home runs, 71 RBI and a batting average of .274 this season.

Padres Player Leaders

• Manny Machado has put up a team-high slugging percentage (.486) and leads the Padres in hits (145). He's batting .294 and with an on-base percentage of .354.
• Including all the qualifying hitters in the big leagues, his batting average puts him 13th, his on-base percentage ranks 36th, and he is 29th in slugging.
• Machado brings a four-game hitting streak into this game. In his last five games he is batting .286 with two doubles, a home run and five RBIs.
• Fernando Tatis Jr. has 25 doubles, two triples, 17 home runs and 74 walks while batting .268. He's slugging .435 with an on-base percentage of .372.
• He ranks 52nd in batting average, 15th in on-base percentage and 78th in slugging percentage in the majors.
• Luis Arraez is batting .289 with 27 doubles, four triples, six home runs and 26 walks.
• Xander Bogaerts is batting .262 with 28 doubles, 10 home runs and 47 walks.

Dodgers vs Padres Head to Head

• 8/17/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/16/2025: 6-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/15/2025: 3-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/19/2025: 5-3 SD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 6/18/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/17/2025: 8-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 10, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/16/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/11/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/10/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 8-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!