Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 9:11 p.m.

Friday's slate in the MLB includes a matchup between the Arizona Diamondbacks and the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (62-66) vs. Cincinnati Reds (67-61)
• Date: Friday, August 22, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and FDSOH

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-134) | CIN: (+114)
• Spread: ARI: -1.5 (+152) | CIN: +1.5 (-184)
• Total: 9 -- Over: (-104) | Under: (-118)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Ryne Nelson (Diamondbacks) - 6-3, 3.58 ERA vs Zack Littell (Reds) - 9-8, 3.52 ERA

The Diamondbacks will give the ball to Ryne Nelson (6-3, 3.58 ERA), who is eyeing win No. 7 on the season, and the Reds will turn to Zack Littell (9-8, 3.52 ERA). When Nelson starts, his team is 10-6-0 against the spread this season. Nelson's team is 5-3 this season when he starts and they are the moneyline favorite. The Reds are 12-13-0 against the spread when Littell starts. The Reds are 8-7 in Littell's 15 starts this season that they were the moneyline underdog.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (57.4%)

Diamondbacks vs Reds Moneyline

• Arizona is a -134 favorite on the moneyline, while Cincinnati is a +114 underdog on the road.

Diamondbacks vs Reds Spread

• The Reds are at +1.5 on the runline against the Diamondbacks. The Reds are -184 to cover the spread, and the Diamondbacks are +152.

Diamondbacks vs Reds Over/Under

• Diamondbacks versus Reds, on Aug. 22, has an over/under of 9, with the over being -104 and the under -118.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have been chosen as favorites in 76 games this year and have walked away with the win 39 times (51.3%) in those games.
• Arizona has a record of 23-21 when favored by -134 or more this year.
• The Diamondbacks and their opponents have gone over the total this season in 61 of their 124 opportunities.
• The Diamondbacks have an against the spread mark of 58-66-0 in 124 games with a line this season.
• The Reds have been the moneyline underdog 67 total times this season. They've finished 34-33 in those games.
• In games it has played as a moneyline underdog with odds of +114 or longer, Cincinnati has gone 14-22 (38.9%).
• The Reds have had an over/under set by bookmakers 121 times, and have combined with opponents to go over the total in 47 of those games (47-69-5).
• The Reds are 65-56-0 ATS this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has an OPS of .826, fueled by an OBP of .388 and a team-best slugging percentage of .439 this season. He has a .287 batting average.
• Among qualified batters in baseball, he ranks 21st in batting average, seventh in on-base percentage, and 75th in slugging.
• Corbin Carroll has 113 hits, which is tops among Arizona batters this season. He's batting .253 with 65 extra-base hits. He's also slugging .556 with an on-base percentage of .328.
• He ranks 94th in batting average, 82nd in on-base percentage and fifth in slugging among qualifying hitters.
• Carroll takes an eight-game streak with at least one hit into this contest. In his last 10 games he is batting .293 with a double, two triples, two home runs, five walks and five RBIs.
• Ketel Marte leads Arizona with an OBP of .394 this season while batting .293 with 55 walks and 70 runs scored.
• Lourdes Gurriel Jr. has been key for Arizona with 115 hits, an OBP of .298 plus a slugging percentage of .418.
• Gurriel enters this game on a seven-game hitting streak. In his last 10 games he is batting .250 with a double, three home runs, three walks and 12 RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up a team-high slugging percentage (.455) and paces the Reds in hits (135). He's batting .273 and with an on-base percentage of .347.
• Including all qualified hitters in MLB, his batting average places him 42nd, his on-base percentage ranks 45th, and he is 60th in slugging.
• TJ Friedl paces his team with a .367 OBP. He has a batting average of .267 while slugging .382.
• Including all qualifying hitters, his batting average puts him 53rd, his on-base percentage is 20th, and he is 133rd in slugging.
• Spencer Steer has 17 doubles, two triples, 15 home runs and 38 walks while hitting .238.
• Gavin Lux is batting .277 with 21 doubles, a triple, five home runs and 43 walks.

Diamondbacks vs Reds Head to Head

• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 6-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/13/2024: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/9/2024: 5-4 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/8/2024: 4-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/7/2024: 6-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/27/2023: 5-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/26/2023: 8-7 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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