Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 5:16 a.m.

Friday's slate in the MLB includes a matchup between the Arizona Diamondbacks and the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (62-66) vs. Cincinnati Reds (67-61)
• Date: Friday, August 22, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and FDSOH

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-134) | CIN: (+114)
• Spread: ARI: -1.5 (+158) | CIN: +1.5 (-192)
• Total: 9 -- Over: (-114) | Under: (-106)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Ryne Nelson (Diamondbacks) - 6-3, 3.58 ERA vs Zack Littell (Reds) - 9-8, 3.52 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Ryne Nelson (6-3) to the mound, while Zack Littell (9-8) will take the ball for the Reds. Nelson and his team are 10-6-0 ATS this season when he starts. Nelson's team is 5-3 this season when he starts and they are the moneyline favorite. The Reds are 12-13-0 ATS in Littell's 25 starts with a set spread. The Reds are 8-7 in Littell's 15 starts this season that they were the underdog on the moneyline.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (57.4%)

Diamondbacks vs Reds Moneyline

• Looking at the moneyline for Reds-Diamondbacks, Cincinnati is the underdog at +114, and Arizona is -134 playing at home.

Diamondbacks vs Reds Spread

• The Reds are at +1.5 on the runline against the Diamondbacks. The Reds are -192 to cover the spread, and the Diamondbacks are +158.

Diamondbacks vs Reds Over/Under

• The over/under for Diamondbacks-Reds on Aug. 22 is 9. The over is -114, and the under is -106.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have been favorites in 76 games this season and have come away with the win 39 times (51.3%) in those contests.
• This year Arizona has won 23 of 44 games when listed as at least -134 on the moneyline.
• The Diamondbacks and their opponents have hit the over in 61 of their 124 games with a total set by oddsmakers this season.
• The Diamondbacks are 58-66-0 against the spread in their 124 games that had a posted line this season.
• The Reds are 34-33 in games they were listed as the moneyline underdog (winning 50.7% of those games).
• When playing as a moneyline underdog with odds of +114 or longer, Cincinnati has a 14-22 record (winning just 38.9% of its games).
• In the 121 games bookmakers have set an over/under for the Reds, they have combined with opponents to go over the total 47 times (47-69-5).
• The Reds have a 65-56-0 record against the spread this season.

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona in slugging percentage (.439) thanks to 42 extra-base hits. He has a .287 batting average and an on-base percentage of .388.
• Among all qualified hitters, he ranks 21st in batting average, his on-base percentage ranks seventh, and he is 75th in slugging.
• Corbin Carroll leads Arizona with 113 hits. He is batting .253 this season and has 65 extra-base hits. He's also slugging .556 with an on-base percentage of .328.
• Among all qualifying players, he is 94th in batting average, 81st in on-base percentage and fifth in slugging percentage.
• Carroll heads into this matchup looking to extend his eight-game hit streak. During his last 10 games he is batting .293 with a double, two triples, two home runs, five walks and five RBIs.
• Ketel Marte leads Arizona in OBP (.394) this season, fueled by 104 hits.
• Lourdes Gurriel Jr. has been key for Arizona with 115 hits, an OBP of .298 plus a slugging percentage of .418.
• Gurriel heads into this game on a seven-game hitting streak. In his last 10 games he is hitting .250 with a double, three home runs, three walks and 12 RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up a slugging percentage of .455 and has 135 hits, both team-high numbers for the Reds. He's batting .273 and with an on-base percentage of .347.
• Including all qualifying hitters, he ranks 42nd in batting average, while his on-base percentage ranks 45th and he is 60th in slugging.
• TJ Friedl has a .367 OBP to pace his team. He has a batting average of .267 while slugging .382.
• His batting average ranks 53rd among all qualified players, his on-base percentage ranks 20th, and he is 133rd in slugging.
• Spencer Steer is batting .238 with 17 doubles, two triples, 15 home runs and 38 walks.
• Gavin Lux is batting .277 with 21 doubles, a triple, five home runs and 43 walks.

Diamondbacks vs Reds Head to Head

• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 6-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/13/2024: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/9/2024: 5-4 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/8/2024: 4-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/7/2024: 6-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/27/2023: 5-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/26/2023: 8-7 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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