Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 6:12 p.m.

On Monday in MLB, the Chicago Cubs are playing the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Cubs vs Pirates Game Info

• Chicago Cubs (85-64) vs. Pittsburgh Pirates (65-85)
• Date: Monday, September 15, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: MLB Network, SportsNet PT, and MARQ

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-124) | PIT: (+106)
• Spread: CHC: -1.5 (+126) | PIT: +1.5 (-152)
• Total: 8 -- Over: (-108) | Under: (-112)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 9-6, 4.15 ERA vs Braxton Ashcraft (Pirates) - 4-2, 2.47 ERA

This contest's pitching matchup is set, as the Cubs will send Jameson Taillon (9-6) to the mound, while Braxton Ashcraft (4-2) will get the nod for the Pirates. Taillon and his team have a record of 9-10-0 against the spread when he starts. Taillon's team has won 66.7% of his starts when they are favored on the moneyline (8-4). The Pirates are 5-1-0 ATS in Ashcraft's six starts that had a set spread. The Pirates have a 3-1 record in Ashcraft's four starts this season when they were the moneyline underdog.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (52.3%)

Cubs vs Pirates Moneyline

• Looking at the moneyline for Cubs-Pirates, Chicago is the favorite at -124, and Pittsburgh is +106 playing at home.

Cubs vs Pirates Spread

• The Pirates are hosting the Cubs, and are +1.5 on the runline. The Pirates are +126 to cover the spread, and the Cubs are -152.

Cubs vs Pirates Over/Under

• Cubs versus Pirates, on Sept. 15, has an over/under of 8, with the over being -108 and the under -112.

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Cubs vs Pirates Betting Trends

• The Cubs have been victorious in 64, or 63.4%, of the 101 contests they have been chosen as favorites in this season.
• Chicago has a record of 55-28 when favored by -124 or more this year.
• Contests with the Cubs have gone over the total set by sportsbooks in 67 of 145 chances this season.
• The Cubs are 67-78-0 against the spread in their 145 games that had a posted line this season.
• The Pirates have a 41-58 record in games they were the underdog on the moneyline (winning 41.4% of those games).
• Pittsburgh is 34-49 (winning 41% of its games) when playing as a moneyline underdog of +106 or longer.
• The Pirates have had an over/under set by bookmakers 142 times, and have combined with opponents to go over the total in 55 of those games (55-81-6).
• The Pirates have covered 54.2% of their games this season, going 77-65-0 against the spread.

Cubs Player Leaders

• Nico Hoerner leads Chicago with a slugging percentage of .400, fueled by 39 extra-base hits. He has a .299 batting average and an on-base percentage of .348.
• Among qualifying hitters, he ranks seventh in batting average, his on-base percentage ranks 39th, and he is 102nd in slugging.
• Hoerner hopes to build on a nine-game hitting streak in this matchup. During his last 10 outings he is hitting .410 with five doubles, a triple, a home run, four walks and five RBIs.
• Pete Crow-Armstrong is hitting .246 with 35 doubles, four triples, 28 home runs and 29 walks, while slugging .479 with an on-base percentage of .289.
• He ranks 96th in batting average, 135th in on-base percentage and 29th in slugging among qualifying batters.
• Ian Happ has collected 126 base hits, an OBP of .344 and a slugging percentage of .422 this season.
• Seiya Suzuki has been key for Chicago with 131 hits, an OBP of .324 plus a slugging percentage of .461.
• Suzuki enters this game on a six-game hitting streak. During his last 10 outings he is hitting .211 with a double, six walks and four RBIs.

Pirates Player Leaders

• Bryan Reynolds has a slugging percentage of .398 and has 133 hits, both team-high numbers for the Pirates. He's batting .242 and with an on-base percentage of .310.
• Including all the qualifying hitters in MLB, his batting average is 106th, his on-base percentage ranks 112th, and he is 105th in slugging.
• Andrew McCutchen has a .335 OBP to pace his team. He has a batting average of .241 while slugging .378.
• He is currently 110th in batting average, 60th in on-base percentage and 126th in slugging percentage among all qualifying hitters.
• Oneil Cruz has 18 doubles, two triples, 19 home runs and 63 walks while batting .204.
• Spencer Horwitz has 21 doubles, nine home runs and 37 walks while batting .260.

Cubs vs Pirates Head to Head

• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/15/2025: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/15/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/14/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 6/13/2025: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/12/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/1/2025: 8-3 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/30/2025: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/29/2025: 9-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)

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