Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 7:12 p.m.

In MLB action on Monday, the St. Louis Cardinals take on the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Reds Game Info

• St. Louis Cardinals (73-77) vs. Cincinnati Reds (74-75)
• Date: Monday, September 15, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSOH

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | CIN: (-104)
• Spread: STL: +1.5 (-184) | CIN: -1.5 (+155)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 7-12, 4.35 ERA vs Zack Littell (Reds) - 9-8, 3.78 ERA

The Cardinals will give the ball to Matthew Liberatore (7-12, 4.35 ERA), who is eyeing win No. 8 on the season, and the Reds will counter with Zack Littell (9-8, 3.78 ERA). Liberatore and his team are 13-12-0 ATS this season when he starts. Liberatore's team has a record of 5-9 this season when he starts and they are the favorite on the moneyline. The Reds have gone 14-15-0 ATS in Littell's 29 starts with a set spread. The Reds have a 9-9 record in Littell's 18 starts this season when they were the underdog on the moneyline.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.6%)

Cardinals vs Reds Moneyline

• The moneyline numbers for Cardinals vs. Reds reveal St. Louis as the favorite (-112) and Cincinnati as the underdog (-104) on the road.

Cardinals vs Reds Spread

• The Reds are 1.5-run favorites against the spread for this matchup with the Cardinals. The Reds are +155 to cover, while the Cardinals are -184 to cover as a 1.5-run underdog on the runline.

Cardinals vs Reds Over/Under

• A combined run total of 8.5 has been set for Cardinals-Reds on Sept. 15, with the over at -115 and the under at -105.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have come away with 32 wins in the 63 contests they have been listed as the favorites in this season.
• St. Louis has a record of 30-29 when favored by -112 or more this year.
• The Cardinals and their opponents have gone over in 74 of their 144 games with a total set by sportsbooks this season.
• The Cardinals are 72-72-0 against the spread in their 144 games that had a posted line this season.
• The Reds have won 38 of the 80 games they were the moneyline underdog this season (47.5%).
• Cincinnati has gone 34-40 when playing as a moneyline underdog with odds of -104 or longer (45.9%).
• The Reds have played in 142 games with a set over/under, and have combined with their opponents to go over the total 56 times (56-78-8).
• The Reds have put together a 73-69-0 record against the spread this season (covering 51.4% of the time).

Cardinals Player Leaders

• Alec Burleson has 128 hits to go with a slugging percentage of .450, both of which are best among St. Louis hitters this season. He has a .281 batting average and an on-base percentage of .332.
• Among qualified hitters in the majors, his batting average ranks 19th, his on-base percentage ranks 65th, and he is 57th in slugging.
• Willson Contreras is batting .255 with 30 doubles, a triple, 20 home runs and 44 walks, while slugging .444 with an on-base percentage of .342.
• Among qualified batters, his batting average ranks him 84th, his on-base percentage 48th, and his slugging percentage 62nd.
• Contreras has picked up at least one hit in two games in a row. During his last five outings he is hitting .389 with a triple, two walks and five RBIs.
• Brendan Donovan leads St. Louis in OBP (.348) this season, fueled by 121 hits.
• Donovan heads into this game with two games in a row with at least one hit. In his last five games he is hitting .300 with a double, a home run, a walk and three RBIs.
• Lars Nootbaar has 13 home runs, 47 RBI and a batting average of .240 this season.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .433 and has 154 hits, both team-high numbers for the Reds. He's batting .263 and with an on-base percentage of .331.
• Including all the qualifying hitters in MLB, he is 57th in batting average, 69th in on-base percentage and 73rd in slugging percentage.
• TJ Friedl paces his team with a .365 on-base percentage. He has a batting average of .261 while slugging .373.
• He is currently 69th in batting average, 14th in on-base percentage and 129th in slugging percentage among all qualifying batters.
• Spencer Steer is hitting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays has 15 doubles, five triples, 15 home runs and 29 walks while hitting .265.

Cardinals vs Reds Head to Head

• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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