Cubs vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 1:14 p.m.

The MLB's Wednesday schedule includes the Chicago Cubs facing the Miami Marlins.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Marlins Game Info

• Chicago Cubs (29-20) vs. Miami Marlins (19-28)
• Date: Wednesday, May 21, 2025
• Time: 1:10 p.m. ET
• Venue: loanDepot park -- Miami, Florida
• Coverage: FDSFL and MARQ

Cubs vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-144) | MIA: (+122)
• Spread: CHC: -1.5 (+112) | MIA: +1.5 (-134)
• Total: 9 -- Over: (-115) | Under: (-105)

Cubs vs Marlins Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 2-0, 6.00 ERA vs Max Meyer (Marlins) - 3-4, 4.47 ERA

The probable pitchers are Cade Horton (2-0) for the Cubs and Max Meyer (3-4) for the Marlins. Horton helped his team cover the spread in his only opportunity this season as a starter. Horton's team won his only start as a favorite this season. The Marlins are 6-3-0 against the spread when Meyer starts. The Marlins are 3-3 in Meyer's six starts this season that they were the underdog on the moneyline.

Cubs vs Marlins Moneyline

• Chicago is the favorite, -144 on the moneyline, while Miami is a +122 underdog despite being at home.

Cubs vs Marlins Spread

• The Marlins are hosting the Cubs, and are +1.5 on the runline. The Marlins are +112 to cover the spread, and the Cubs are -134.

Cubs vs Marlins Over/Under

• Cubs versus Marlins on May 21 has an over/under of 9 runs, with the odds on the over -115 and the under set at -105.

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Cubs vs Marlins Betting Trends

• The Cubs have been chosen as favorites in 27 games this year and have walked away with the win 19 times (70.4%) in those games.
• Chicago has a record of 10-6 when favored by -144 or more this year.
• The Cubs and their opponents have gone over in 30 of their 47 games with a total set by sportsbooks this season.
• The Cubs are 25-22-0 against the spread in their 47 games that had a posted line this season.
• The Marlins have been the underdog on the moneyline 41 total times this season. They've gone 15-26 in those games.
• Miami has an 11-19 record (winning just 36.7% of its games) when playing as a moneyline underdog of +122 or longer.
• The Marlins have combined with opponents to go over the total 29 times this season for a 29-18-0 record against the over/under.
• The Marlins have a 25-22-0 record against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .381 this season while batting .268 with 35 walks and 37 runs scored. He has a slugging percentage of .532.
• Among qualified hitters in MLB, his batting average ranks 62nd, his on-base percentage ranks 19th, and he is 17th in slugging.
• Pete Crow-Armstrong leads Chicago with 55 hits and a team-best slugging percentage of .565. He's batting .285 with an on-base percentage of .319.
• Among qualified hitters, he is 38th in batting average, 97th in on-base percentage and seventh in slugging percentage.
• Seiya Suzuki has 46 hits this season and has a slash line of .253/.310/.533.
• Suzuki enters this matchup with two games in a row with at least one hit. During his last five outings he is batting .368 with four doubles, a home run, three walks and eight RBIs.
• Dansby Swanson has 10 home runs, 27 RBI and a batting average of .262 this season.
• Swanson takes a six-game hitting streak into this game. In his last 10 outings he is batting .389 with three home runs, five walks and seven RBIs.

Marlins Player Leaders

• Kyle Stowers has 49 hits with a .383 on-base percentage and a .563 slugging percentage, all club-highs for the Marlins. He's batting .310.
• Including all qualified hitters in the big leagues, he is 10th in batting average, 18th in on-base percentage and ninth in slugging percentage.
• Stowers hopes to build on an eight-game hitting streak in this matchup. In his last 10 outings he is hitting .361 with two doubles, a triple, four home runs, two walks and five RBIs.
• Eric Wagaman is hitting .242 with 10 doubles, a triple, three home runs and 12 walks. He's slugging .376 with an on-base percentage of .294.
• Including all qualified hitters, he ranks 101st in batting average, 127th in on-base percentage and 116th in slugging percentage.
• Liam Hicks has four doubles, a triple, four home runs and seven walks while batting .280.
• Otto Lopez is hitting .231 with five doubles, three home runs and 10 walks.

Cubs vs Marlins Head to Head

• 5/20/2025: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/19/2025: 8-7 MIA (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/14/2025: 3-1 MIA (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/13/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/12/2025: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 8/25/2024: 7-2 MIA (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/24/2024: 14-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/23/2024: 6-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-3 MIA (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/20/2024: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)

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