Cardinals vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 2:12 a.m.

The MLB slate on Saturday includes the St. Louis Cardinals facing the Cincinnati Reds.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Reds Game Info

• St. Louis Cardinals (41-35) vs. Cincinnati Reds (39-37)
• Date: Saturday, June 21, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSOH

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-196) | CIN: (+164)
• Spread: STL: -1.5 (+104) | CIN: +1.5 (-125)
• Total: 9 -- Over: (-115) | Under: (-105)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 7-2, 3.84 ERA vs Brent Suter (Reds) - 1-0, 2.91 ERA

The probable pitchers are Sonny Gray (7-2) for the Cardinals and Brent Suter (1-0) for the Reds. Gray and his team are 9-5-0 ATS this season when he starts. Gray's team has won 87.5% of his starts when they are favored on the moneyline (7-1). Suter has started two games with set spreads, and the Reds covered in both chances. The Reds were the underdog on the moneyline for two Suter starts this season -- they won both.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (61.2%)

Cardinals vs Reds Moneyline

• The moneyline numbers for Cardinals vs. Reds reveal St. Louis as the favorite (-196) and Cincinnati as the underdog (+164) on the road.

Cardinals vs Reds Spread

• The Reds are at the Cardinals, and are +1.5 on the runline. The Reds are +104 to cover the spread, and the Cardinals are -125.

Cardinals vs Reds Over/Under

• The Cardinals-Reds game on June 21 has been given an over/under of 9 runs. The over is set at -115 and the under at -105.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have come away with 18 wins in the 34 contests they have been listed as the favorites in this season.
• Oddsmakers have given St. Louis the best odds of winning it has seen this season, with a -196 moneyline listed for this contest.
• The Cardinals and their opponents have hit the over in 40 of their 76 games with a total set by oddsmakers this season.
• The Cardinals are 42-34-0 against the spread in their 76 games that had a posted line this season.
• The Reds have compiled a 21-20 record in games they were listed as the moneyline underdog (winning 51.2% of those games).
• Cincinnati has played as a moneyline underdog of +164 or longer in only two games this season, which it lost both.
• In the 72 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 33 times (33-37-2).
• The Reds have covered 51.4% of their games this season, going 37-35-0 ATS.

Cardinals Player Leaders

• Nolan Arenado is hitting .247 with 11 doubles, a triple, nine home runs and 23 walks. He has an on-base percentage of .310 and a slugging percentage of .397.
• Among all qualifying hitters in MLB, he is 95th in batting average, 113th in on-base percentage, and 107th in slugging.
• Brendan Donovan leads St. Louis with 83 hits and an OBP of .382, plus a team-best slugging percentage of .438. He's batting .313.
• Among qualifying hitters, he is ninth in batting average, 16th in on-base percentage and 70th in slugging percentage.
• Willson Contreras has 66 hits this season and has a slash line of .249/.339/.423.
• Contreras enters this matchup with two games in a row with at least one hit. During his last five outings he is hitting .167 with a double, two home runs, three walks and seven RBIs.
• Lars Nootbaar has been key for St. Louis with 64 hits, an OBP of .335 plus a slugging percentage of .371.
• Nootbaar brings a three-game hitting streak into this matchup. In his last five games he is batting .211 with a double, a home run, three walks and three RBIs.

Reds Player Leaders

• Elly De La Cruz has accumulated 76 hits, a team-best for the Reds. He's batting .263 and slugging .478 with an on-base percentage of .344.
• Including all the qualified hitters in the majors, his batting average is 66th, his on-base percentage ranks 55th, and he is 32nd in slugging.
• TJ Friedl's .379 OBP and .438 slugging percentage both lead his team. He has a batting average of .290.
• Including all qualified players, he ranks 23rd in batting average, 17th in on-base percentage and 70th in slugging percentage.
• Gavin Lux is hitting .270 with 14 doubles, a triple, three home runs and 31 walks.
• Matt McLain is hitting .200 with five doubles, eight home runs and 28 walks.

Cardinals vs Reds Head to Head

• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/12/2024: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/11/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/10/2024: 3-0 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 9-2 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/13/2024: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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