Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 2:12 a.m.

The St. Louis Cardinals are among the MLB teams playing on Wednesday, versus the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (65-68) vs. Pittsburgh Pirates (58-75)
• Date: Wednesday, August 27, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Fox Sports 1, FDSMW, and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-178) | PIT: (+150)
• Spread: STL: -1.5 (+125) | PIT: +1.5 (-150)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 12-6, 4.33 ERA vs Carmen Mlodzinski (Pirates) - 3-7, 3.89 ERA

The probable pitchers are Sonny Gray (12-6) for the Cardinals and Carmen Mlodzinski (3-7) for the Pirates. Gray's team is 13-11-0 against the spread in his starts this season. Gray's team is 12-4 this season when he starts and they are the moneyline favorite. The Pirates have gone 5-5-0 against the spread when Mlodzinski starts. The Pirates are 3-7 in Mlodzinski's 10 starts this season that they were the moneyline underdog.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (60.1%)

Cardinals vs Pirates Moneyline

• Looking at the moneyline for Pirates-Cardinals, Pittsburgh is the underdog at +150, and St. Louis is -178 playing at home.

Cardinals vs Pirates Spread

• The Cardinals are hosting the Pirates and are favored by 1.5 runs on the spread. The Cardinals are +125 to cover the runline, with the Pirates being -150.

Cardinals vs Pirates Over/Under

• An over/under of 7.5 has been set for Cardinals-Pirates on Aug. 27, with the over being -100 and the under -122.

Bet on St. Louis Cardinals vs. Pittsburgh Pirates on FanDuel today!

Cardinals vs Pirates Betting Trends

• The Cardinals have been chosen as favorites in 57 games this year and have walked away with the win 29 times (50.9%) in those games.
• This season St. Louis has been victorious three times in five chances when named as a favorite of at least -178 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 67 of their 127 opportunities.
• The Cardinals have an against the spread record of 64-63-0 in 127 games with a line this season.
• The Pirates have gone 35-50 in games they were listed as the moneyline underdog (winning 41.2% of those games).
• Pittsburgh is 9-19 (winning just 32.1% of its games) when playing as a moneyline underdog of +150 or longer.
• The Pirates have played in 125 games with an over/under set, and have combined with their opponents to go over the total 50 times (50-69-6).
• The Pirates have a 68-57-0 record ATS this season (covering 54.4% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis with 123 hits and a team-best slugging percentage of .459. He's batting .291 with an on-base percentage of .341.
• Among all qualified hitters in MLB, his batting average ranks 15th, his on-base percentage ranks 55th, and he is 54th in slugging.
• Burleson will look for his fifth straight game with a hit in this contest. In his last five games he is hitting .364 with a double, a home run and three RBIs.
• Willson Contreras is batting .259 with 30 doubles, 19 home runs and 40 walks, while slugging .455 with an on-base percentage of .343.
• Among all qualifying players, he is 77th in batting average, 53rd in on-base percentage and 59th in slugging percentage.
• Masyn Winn has collected 116 base hits, an OBP of .310 and a slugging percentage of .372 this season.
• Lars Nootbaar has 13 home runs, 44 RBI and a batting average of .234 this season.

Pirates Player Leaders

• Bryan Reynolds has a slugging percentage of .414 and has 122 hits, both team-best numbers for the Pirates. He's batting .247 and with an on-base percentage of .306.
• Including all the qualifying hitters in MLB, he is 103rd in batting average, 122nd in on-base percentage and 92nd in slugging percentage.
• Oneil Cruz is hitting .205 with 17 doubles, two triples, 18 home runs and 55 walks. He's slugging .394 with an on-base percentage of .303.
• Including all qualifying players, he ranks 156th in batting average, 127th in on-base percentage and 118th in slugging percentage.
• Andrew McCutchen has accumulated an on-base percentage of .333, a team-high for the Pirates.
• Isiah Kiner-Falefa has 19 doubles, two triples, a home run and 17 walks while batting .267.

Cardinals vs Pirates Head to Head

• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/7/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/6/2025: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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