Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for July 27

Odds updated as of 2:11 p.m.

The St. Louis Cardinals will take on the San Diego Padres in MLB action on Sunday.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Padres Game Info

• St. Louis Cardinals (54-52) vs. San Diego Padres (56-49)
• Date: Sunday, July 27, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SDPA

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-124) | SD: (+106)
• Spread: STL: -1.5 (+152) | SD: +1.5 (-184)
• Total: 9 -- Over: (-105) | Under: (-115)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Michael McGreevy (Cardinals) - 2-1, 3.49 ERA vs Stephen Kolek (Padres) - 3-5, 4.28 ERA

This contest's pitching matchup is set, as the Cardinals will send Michael McGreevy (2-1) to the mound, while Stephen Kolek (3-5) will get the nod for the Padres. McGreevy and his team have a record of 3-1-0 against the spread when he starts. McGreevy's team is 2-0 this season when he starts and they're favored on the moneyline. The Padres have an 8-5-0 ATS record in Kolek's 13 starts with a set spread. The Padres are 1-5 in Kolek's six starts this season that they were the underdog on the moneyline.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53%)

Cardinals vs Padres Moneyline

• The moneyline numbers for Cardinals vs. Padres reveal St. Louis as the favorite (-124) and San Diego as the underdog (+106) on the road.

Cardinals vs Padres Spread

• The Padres are +1.5 on the run line against the Cardinals. The Padres are -184 to cover, and the Cardinals are +152.

Cardinals vs Padres Over/Under

• The over/under for Cardinals-Padres on July 27 is 9. The over is -105, and the under is -115.

Bet on St. Louis Cardinals vs. San Diego Padres on FanDuel today!

Cardinals vs Padres Betting Trends

• The Cardinals have been favorites in 48 games this season and have come away with the win 25 times (52.1%) in those contests.
• This year St. Louis has won 19 of 32 games when listed as at least -124 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 53 of their 103 opportunities.
• The Cardinals are 55-48-0 against the spread in their 103 games that had a posted line this season.
• The Padres have won 46.9% of the games this season they were the underdog on the moneyline (23-26).
• In games it has played as a moneyline underdog with odds of +106 or longer, San Diego has an 18-21 record (winning 46.2% of its games).
• In the 103 games oddsmakers have set an over/under for the Padres, they have combined with opponents to go over the total 42 times (42-58-3).
• The Padres have a 56-47-0 record against the spread this season (covering 54.4% of the time).

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with an OBP of .359, plus a team-best slugging percentage of .425. He's batting .290 on the season.
• Among all qualified hitters in baseball, he is 18th in batting average, 32nd in on-base percentage, and 78th in slugging.
• Willson Contreras has 97 hits, which is tops among St. Louis batters this season. He's batting .264 with 42 extra-base hits. He's also slugging .455 with an on-base percentage of .352.
• Among qualified hitters, his batting average places him 71st, his on-base percentage 40th, and his slugging percentage 57th.
• Nolan Arenado has 83 hits this season and has a slash line of .237/.298/.371.
• Alec Burleson has 12 home runs, 44 RBI and a batting average of .285 this season.

Padres Player Leaders

• Manny Machado has racked up a slugging percentage of .498 and has 118 hits, both team-high numbers for the Padres. He's batting .294 and with an on-base percentage of .355.
• Including all the qualifying hitters in the big leagues, his batting average is 12th, his on-base percentage ranks 36th, and he is 22nd in slugging.
• Machado heads into this game on a four-game hitting streak. During his last five outings he is batting .450 with two doubles, a home run and three RBIs.
• Fernando Tatis Jr. leads his team with a .363 OBP. He has a batting average of .266 while slugging .448.
• His batting average ranks 63rd among all qualified players, his on-base percentage is 27th, and he is 63rd in slugging.
• Luis Arraez is hitting .287 with 20 doubles, four triples, five home runs and 20 walks.
• Xander Bogaerts is hitting .266 with 23 doubles, six home runs and 43 walks.

Cardinals vs Padres Head to Head

• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/1/2024: 6-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)

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