Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for July 26

Odds updated as of 7:12 p.m.

The Saturday slate in MLB includes a matchup between the St. Louis Cardinals and the San Diego Padres.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Padres Game Info

• St. Louis Cardinals (54-51) vs. San Diego Padres (55-49)
• Date: Saturday, July 26, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SDPA

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-142) | SD: (+120)
• Spread: STL: -1.5 (+134) | SD: +1.5 (-162)
• Total: 9 -- Over: (-112) | Under: (-108)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 6-7, 4.13 ERA vs Randy Vasquez (Padres) - 3-4, 3.73 ERA

The probable pitchers are Matthew Liberatore (6-7) for the Cardinals and Randy Vasquez (3-4) for the Padres. Liberatore and his team have a record of 9-9-0 against the spread when he starts. When Liberatore starts a game and his team is the favorite on the moneyline, they have a record of 4-8. The Padres are 12-7-0 ATS in Vasquez's 19 starts with a set spread. The Padres have been the underdog on the moneyline in 14 of Vasquez's starts this season, and they went 7-7 in those matchups.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.6%)

Cardinals vs Padres Moneyline

• Looking at the moneyline for Cardinals-Padres, St. Louis is the favorite at -142, and San Diego is +120 playing on the road.

Cardinals vs Padres Spread

• The Cardinals are hosting the Padres and are favored by 1.5 runs on the spread. The Cardinals are +134 to cover the runline, with the Padres being -162.

Cardinals vs Padres Over/Under

• The over/under for Cardinals-Padres on July 26 is 9. The over is -112, and the under is -108.

Bet on St. Louis Cardinals vs. San Diego Padres on FanDuel today!

Cardinals vs Padres Betting Trends

• The Cardinals have been favorites in 47 games this season and have come away with the win 25 times (53.2%) in those contests.
• This season St. Louis has come away with a win 12 times in 18 chances when named as a favorite of at least -142 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 53 of their 102 opportunities.
• The Cardinals have posted a record of 55-47-0 against the spread this season.
• The Padres have won 22 of the 48 games they were listed as the moneyline underdog this season (45.8%).
• In games it has played as a moneyline underdog with odds of +120 or longer, San Diego has a record of 12-15 (44.4%).
• The Padres have played in 102 games with an over/under set, and have combined with opponents to go over the total 42 times (42-57-3).
• The Padres have covered 53.9% of their games this season, going 55-47-0 against the spread.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis OPS (.788) this season. He has a .293 batting average, an on-base percentage of .360, and a slugging percentage of .428.
• Among qualifying hitters in baseball, his batting average ranks 14th, his on-base percentage ranks 32nd, and he is 77th in slugging.
• Willson Contreras leads St. Louis with 97 hits. He is batting .266 this season and has 42 extra-base hits. He's also slugging .458 with an on-base percentage of .351.
• His batting average is 71st among qualified players, his on-base percentage 44th, and his slugging percentage 54th.
• Contreras heads into this matchup looking to extend his six-game hit streak. During his last 10 outings he is batting .351 with seven doubles, two home runs, three walks and eight RBIs.
• Alec Burleson has collected 91 base hits, an OBP of .336 and a slugging percentage of .455 this season.
• Nolan Arenado has been key for St. Louis with 83 hits, an OBP of .298 plus a slugging percentage of .375.

Padres Player Leaders

• Manny Machado has racked up a slugging percentage of .494 and has 116 hits, both team-high figures for the Padres. He's batting .291 and with an on-base percentage of .350.
• Including all qualifying players, he ranks 16th in batting average, while his on-base percentage is 48th and he is 25th in slugging.
• Machado hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .333 with a double, a home run and three RBIs.
• Fernando Tatis Jr.'s .365 OBP paces his team. He has a batting average of .269 while slugging .452.
• Including all qualifying hitters, his batting average puts him 58th, his on-base percentage is 26th, and he is 60th in slugging.
• Luis Arraez is hitting .287 with 20 doubles, four triples, five home runs and 20 walks.
• Xander Bogaerts has 23 doubles, six home runs and 43 walks while hitting .269.

Cardinals vs Padres Head to Head

• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/1/2024: 6-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/24/2023: 12-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)

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