Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for July 26

Odds updated as of 11:12 a.m.

The MLB slate on Saturday includes the St. Louis Cardinals taking on the San Diego Padres.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Padres Game Info

• St. Louis Cardinals (54-51) vs. San Diego Padres (55-49)
• Date: Saturday, July 26, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SDPA

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-146) | SD: (+124)
• Spread: STL: -1.5 (+132) | SD: +1.5 (-160)
• Total: 9 -- Over: (-110) | Under: (-110)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 6-7, 4.13 ERA vs Randy Vasquez (Padres) - 3-4, 3.73 ERA

The Cardinals will give the ball to Matthew Liberatore (6-7, 4.13 ERA), who is eyeing win No. 7 on the season, and the Padres will turn to Randy Vasquez (3-4, 3.73 ERA). Liberatore and his team are 9-9-0 ATS this season when he starts. Liberatore's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 4-8. The Padres have a 12-7-0 record against the spread in Vasquez's starts. The Padres have been the moneyline underdog in 14 of Vasquez's starts this season, and they went 7-7 in those matchups.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.6%)

Cardinals vs Padres Moneyline

• St. Louis is the favorite, -146 on the moneyline, while San Diego is a +124 underdog on the road.

Cardinals vs Padres Spread

• The Padres are +1.5 on the run line against the Cardinals. The Padres are -160 to cover, and the Cardinals are +132.

Cardinals vs Padres Over/Under

• An over/under of 9 has been set for Cardinals-Padres on July 26, with the over being -110 and the under -110.

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Cardinals vs Padres Betting Trends

• The Cardinals have won in 25, or 53.2%, of the 47 contests they have been named as odds-on favorites in this year.
• This season St. Louis has come away with a win nine times in 13 chances when named as a favorite of at least -146 on the moneyline.
• The Cardinals' games have gone over the total in 53 of their 102 opportunities.
• The Cardinals have posted a record of 55-47-0 against the spread this season.
• The Padres have won 22 of the 48 games they were the moneyline underdog this season (45.8%).
• When playing as a moneyline underdog with odds of +124 or longer, San Diego has a record of 12-14 (46.2%).
• The Padres have played in 102 games with a set over/under, and have combined with opponents to go over the total 42 times (42-57-3).
• The Padres have a 55-47-0 record against the spread this season.

Cardinals Player Leaders

• Brendan Donovan has an OPS of .788, fueled by an OBP of .360 to go with a slugging percentage of .428. He has a .293 batting average, as well.
• Among qualifying hitters in MLB, his batting average ranks 13th, his on-base percentage ranks 32nd, and he is 78th in slugging.
• Willson Contreras leads St. Louis with 97 hits. He is batting .266 this season and has 42 extra-base hits. He's also slugging .458 with an on-base percentage of .351.
• Among qualified batters, his batting average places him 73rd, his on-base percentage 45th, and his slugging percentage 54th.
• Contreras has picked up a hit in six games in a row. During his last 10 games he is batting .351 with seven doubles, two home runs, three walks and eight RBIs.
• Nolan Arenado has collected 83 base hits, an OBP of .298 and a slugging percentage of .375 this season.
• Alec Burleson has 12 home runs, 44 RBI and a batting average of .285 this season.

Padres Player Leaders

• Manny Machado has a slugging percentage of .494 and has 116 hits, both team-high marks for the Padres. He's batting .291 and with an on-base percentage of .350.
• Including all qualifying hitters in the big leagues, his batting average puts him 15th, his on-base percentage ranks 49th, and he is 25th in slugging.
• Machado enters this matchup on a three-game hitting streak. During his last five outings he is batting .333 with a double, a home run and three RBIs.
• Fernando Tatis Jr. has a .365 OBP to lead his team. He has a batting average of .269 while slugging .452.
• He is currently 57th in batting average, 26th in on-base percentage and 59th in slugging percentage among all qualifying hitters.
• Luis Arraez has 20 doubles, four triples, five home runs and 20 walks while batting .287.
• Xander Bogaerts has 23 doubles, six home runs and 43 walks while batting .269.

Cardinals vs Padres Head to Head

• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/1/2024: 6-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/24/2023: 12-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)

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